DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt-26

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_491435.2	Gene:	ugt-26 / 172085	WormBaseID:	WBGene00015695	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	151/575 - (26%)
Similarity:	258/575 - (44%)	Gaps:	114/575 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVHKSGIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVV 65
            |:..|.:.:.|  .:|.|......|||....:.:.||.......|..|.|.||||   |.|.|:.
Worm     1 MIRMSVVSISL--VLCTLSLVSSLNILVHSPAYAASHTNFMARLADTLTEAGHNV---TFLVPIA 60

  Fly    66 NHKNITVIMVPLTK-----EESQQM--------------------SDTIGAMSKTDNSNMILSML 105
            ..:....:.|.|||     |:.::|                    |.:|.||....|..|||:..
Worm    61 LEERRDKLGVKLTKDVIIVEQDEEMKSKLVPHSGSIEFLWIIEMDSSSIDAMFSWYNEIMILTCE 125

  Fly   106 RMMGQMEFMFDKMAGALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVK-APVIVVATMP 169
            ..|...:.|.:.                :...||:.::..| .:..||..:::. ...|:|::..
Worm   126 NFMRNKQVMSEL----------------KSRHFDVAIAEPF-TICGLGLFEELNIKKTILVSSCA 173

  Fly   170 PNQLLNPLIGNPLEIAYVPSISDSVEKGKGMSFRQ-----RLAGYSSSFFFGIFDFVTQRRSKRL 229
            ....:.|.||.|.:.:.||::|..|  |:.||..:     ||...:.:....:||..|     |:
Worm   174 HYDFMLPHIGEPEDFSSVPTLSSKV--GEEMSMTEKWENYRLVAETKASLAKLFDAET-----RI 231

  Fly   230 YKELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGI-----QVKDTPDPLPQ 289
            |:|.||.|  :|::.||:.:.||.|..|:...:.| |.::...|.||||     |:|.  :.|.:
Worm   232 YRESFGSD--IPDWKELMSSASLYFTNSNPFIDYP-RASIQKTISIGGITVDFQQIKS--EKLNK 291

  Fly   290 NMAEFLGNATDGAILLSLGSNVKGSHINP-------DTVVKMFNVLSKLKQRVIWKWE--DLEKT 345
            ...|.| |....::|:|.||||....:..       :|:..|.||      ..|||:|  |:...
Worm   292 EWEEVL-NKRQKSMLISFGSNVPSDKMPAAWKAGIFETIKSMPNV------TFIWKYESDDVSFA 349

  Fly   346 PGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQ 410
            .|.| ||.:|||:||..:|..|.:..|:.|.|.|...|..|..||.:.:|::|||..||:::.:.
Worm   350 DGIS-NIHFSKWVPQTALLNDPRLSAFLTHGGLGSTNELAYCAKPAVMVPIYGDQTRNANMLARH 413

  Fly   411 GFGLTQSLLSLEE------QPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVI 469
            |     |::.|.:      |..|:|:.:||.|.||.:.....:.:.:::|.:.:|:|:.:||:|.
Worm   414 G-----SVIVLHKKELANVQRVKKAVHDILYNKQYTESAERIAEMIKNQPKTPKETVVRYTEFVA 473

  Fly   470 RH--------HGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFI 516
            ::        ||.        .:::.....:|||:|.|:.:|.::.:..|:::::
Worm   474 KYGPFPQMAPHGR--------KLTYFQKTFLDIYSLFALGVVSVLTVAFLVIRYV 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	142/540 (26%)
ugt-26	NP_491435.2	egt	4..481	CDD:223071	141/523 (27%)
ugt-26	NP_491435.2	UDPGT	34..525	CDD:278624	143/540 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14289
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910