DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	158/569 - (27%)
Similarity:	254/569 - (44%)	Gaps:	94/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 GIYLLLATAICVLGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVIT------VLKPV 64
            |:.||||:     |..|...:|.|  .:..||........:.|..:||.|.|:.      :.||:
  Rat    13 GLCLLLAS-----GFGHAGKLLVV--PMDGSHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKPL 70

  Fly    65 VNHKNITV--IMVPLTKEE-SQQMSDTIGAMSKTDNSNMILSMLR--MMGQMEFMFDKMAGALKD 124
                |.||  ..|..|:|: :::....|.:..||.....:|.:|.  ..|..|.:|.......||
  Rat    71 ----NFTVKTYSVSHTQEDLNREFKFFIDSQWKTQQEGGVLPLLTSPAQGFFELLFSHCRSLFKD 131

  Fly   125 DRVRDLYLNRDNKFDLVLSGYFMNVYQLGFAKKVKAPVIVVA--------------TMPPNQLLN 175
            .::.: || :.:.||.|....| :|..|..||....|.:|.:              ..||
  Rat   132 KKLVE-YL-KQSSFDAVFLDPF-DVCGLTVAKYFSLPSVVFSRGIFCHYLEEGSQCPSPP----- 188

  Fly   176 PLIGNPLEIAYVP----SISDSVEKGKGMSFRQR---LAGYSSSFFF--GIFDFVTQRRSKRLYK 231
                     :|||    .::|:      |:|::|   |..|.....|  ..|...|...|:.|..
  Rat   189 ---------SYVPRGILKLTDT------MTFKERVWNLLSYMGEHAFCPSFFKTATDIASEVLQT 238

  Fly   232 ELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLG 296
            .:...|...|....|::..    |....|.  |:.|||   |.||||..... .||.:....::
  Rat   239 PVTMTDLFSPVSVWLLRTD----FTLELPR--PVMPNV---IHIGGINCHQR-KPLSKEFEAYV- 292

  Fly   297 NAT--DGAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLP 359
            ||:  .|.::.||||.|  |.|.....:::...|.::.|.|:|::.. .:....:.|....||||
  Rat   293 NASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTG-TRPSNLAKNTILVKWLP 354

  Fly   360 QDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQ 424
            |:|:|.||..:.||.|:|..||.|...:|.||:.:|:||||..||..|..:|.|:|.::|.:...
  Rat   355 QNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTAD 419

  Fly   425 PFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVH-MSFIA 488
            ..:.|:..:::|..|.:.:...|||::|||:...:..::|.|||:||.||.||: |..| :::..
  Rat   420 DLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLR-PAAHDLTWYQ 483

  Fly   489 ANNIDIYA-LIAVVLVILVLLLKLLLQFIYRKIFA------KPKKEKKH 530
            .:::|:.. |:|:||.::.::.| ...:..||.|.      |..|.|.|
  Rat   484 YHSLDVIGFLLAIVLTVVFIVYK-SCAYGCRKCFGGKGRVKKSHKSKTH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	144/518 (28%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	147/540 (27%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	83/251 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910