DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and UGT2A1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001376494.1	Gene:	UGT2A1 / 10941	HGNCID:	12542	Length:	737	Species:	Homo sapiens

Alignment Length:	539	Identity:	134/539 - (24%)
Similarity:	247/539 - (45%)	Gaps:	68/539 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVI----TVL------KPVVNHKNITV 72
            |.|.|..||          .:|::     .|.:|.|||||:    |:.      .||    |..|
Human   238 LDGSHWLNI----------KIILE-----ELIQRNHNVTVLASSATLFINSNPDSPV----NFEV 283

  Fly    73 IMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKM--------AGALKDDRVRD 129
            |.|...|.....:.:.: .|...|:....|::.....::..:.|..        .|.||:.::
Human   284 IPVSYKKSNIDSLIEHM-IMLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKL-- 345

  Fly   130 LYLNRDNK--FDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGN-PLEIAYVP-SI 190
              :.|..|  ||::::........| .|.|:..|.:......|...:....|. |..::||| ::
Human   346 --MARLQKGGFDVLVADPVTICGDL-VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAAL 407

  Fly   191 SDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQR---RSKRLYKELFGDDPNMPEYSELVKNTSL 252
            |:..::   |:|.:|:   .::..:.:.|::.|.   .....|.::.|....:   .|.:....:
Human   408 SELTDQ---MTFGERI---KNTISYSLQDYIFQSYWGEWNSYYSKILGRPTTL---CETMGKAEI 463

  Fly   253 IFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHI 316
            ....::...|.| ||.:|....:||:..|.. .|||:.|.||: .:..:|.::.||||.||  ::
Human   464 WLIRTYWDFEFP-RPYLPNFEFVGGLHCKPA-KPLPKEMEEFIQSSGKNGVVVFSLGSMVK--NL 524

  Fly   317 NPDTVVKMFNVLSKLKQRVIWKWEDLE-KTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGG 380
            ..:....:.:.|:::.|:|:|:::..: .|.|.:..:|  .|:||:|:|.||..|.||.|.|..|
Human   525 TEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNG 587

  Fly   381 ITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVAS 445
            |.||.|||.||:.:|:|.|||.|...|..:|..:..:|.::.......|:..:::.|.|.:....
Human   588 IYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMR 652

  Fly   446 FSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLK 510
            .|.::.|:|:...:..::|.|:|:||.||.||:.....:::...:::|:...:.|.:...:.|:.
Human   653 LSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVI 717

  Fly   511 LLLQFIYRKIFAKPKKEKK 529
            ....|..:| |.|..|:||
Human   718 QCCLFSCQK-FGKIGKKKK 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	124/498 (25%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	128/526 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840