Protein Alignment Ugt37A2 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_650228.1
• Gene: Ugt37A2 / 41573
• FlyBaseID: FBgn0038082
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 134/539 - (24%)
• Similarity: 247/539 - (45%)
• Gaps: 68/539 - (12%)

  Fly    18 LGGCHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVI----TVL------KPVVNHKNITV 72
            |.|.|..||          .:|::     .|.:|.|||||:    |:.      .||    |..|
Human   238 LDGSHWLNI----------KIILE-----ELIQRNHNVTVLASSATLFINSNPDSPV----NFEV 283

  Fly    73 IMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKM--------AGALKDDRVRD 129
            |.|...|.....:.:.: .|...|:....|::.....::..:.|..        .|.||:.::
Human   284 IPVSYKKSNIDSLIEHM-IMLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGVLKNPKL-- 345

  Fly   130 LYLNRDNK--FDLVLSGYFMNVYQLGFAKKVKAPVIVVATMPPNQLLNPLIGN-PLEIAYVP-SI 190
              :.|..|  ||::::........| .|.|:..|.:......|...:....|. |..::||| ::
Human   346 --MARLQKGGFDVLVADPVTICGDL-VALKLGIPFMYTLRFSPASTVERHCGKIPAPVSYVPAAL 407

  Fly   191 SDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQR---RSKRLYKELFGDDPNMPEYSELVKNTSL 252
            |:..::   |:|.:|:   .::..:.:.|::.|.   .....|.::.|....:   .|.:....:
Human   408 SELTDQ---MTFGERI---KNTISYSLQDYIFQSYWGEWNSYYSKILGRPTTL---CETMGKAEI 463

  Fly   253 IFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHI 316
            ....::...|.| ||.:|....:||:..|.. .|||:.|.||: .:..:|.::.||||.||  ::
Human   464 WLIRTYWDFEFP-RPYLPNFEFVGGLHCKPA-KPLPKEMEEFIQSSGKNGVVVFSLGSMVK--NL 524

  Fly   317 NPDTVVKMFNVLSKLKQRVIWKWEDLE-KTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGG 380
            ..:....:.:.|:::.|:|:|:::..: .|.|.:..:|  .|:||:|:|.||..|.||.|.|..|
Human   525 TEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLF--DWIPQNDLLGHPKTKAFITHGGTNG 587

  Fly   381 ITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVAS 445
            |.||.|||.||:.:|:|.|||.|...|..:|..:..:|.::.......|:..:::.|.|.:....
Human   588 IYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMR 652

  Fly   446 FSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLK 510
            .|.::.|:|:...:..::|.|:|:||.||.||:.....:::...:::|:...:.|.:...:.|:.
Human   653 LSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVI 717

  Fly   511 LLLQFIYRKIFAKPKKEKK 529
            ....|..:| |.|..|:||
Human   718 QCCLFSCQK-FGKIGKKKK 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	GT1_Gtf-like	24..464	CDD:340817	112/466 (24%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	128/526 (24%)