DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	546	Identity:	150/546 - (27%)
Similarity:	259/546 - (47%)	Gaps:	58/546 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLATAICVLGG-CHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKNITV- 72
            |..|.:.:.|. |.|..||  ...|..||.:......|.|..:||.|.||.........:|.|.
Zfish    13 LWITVMIIFGSLCDGGKIL--VAPLEGSHWVNMDILIKALHGQGHTVDVIRNTNSWFVKENSTYY 75

  Fly    73 --IMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDR-----VRDL 130
              |.:|.:|...::..:.: ...|.|......|.|   |.::...|......:..:     :.::
Zfish    76 NSITIPDSKGMDEEFVEDV-LTKKIDYERGKGSWL---GGVQLFLDVSKAVYESHKLVCRLITNI 136

  Fly   131 YLNRD-------NKFDLVLS--GYFMNVYQLGFAKKVKAPVIV-VATMPPNQLLNPLIGN----P 181
            :.:.|       .|:||:|:  |:...:.   .|.|:|.|::. |....|.:      |:    |
Zfish   137 FESEDILKALQEKKYDLMLTDPGWGTGII---LAHKLKLPMVYNVRWTTPGE------GHFDIAP 192

  Fly   182 LEIAYVP-SISDSVEKGKGMSFRQRLAGYSSSFFFGIFDFVTQRRSKRLYKEL---FGDDPNMPE 242
            ..::|:| :.|.:.:|   |||.||:.   :.|::.:.||...|.:...|:.|   :.|.|  .:
Zfish   193 SPMSYIPLTGSGNTDK---MSFFQRVI---NVFYYLLLDFQCSRFNVPQYQALCDKYFDPP--VD 249

  Fly   243 YSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATD-GAILLS 306
            :.:|::...|.........|.| ||.:|..|..||.|...| .|||.::.:|:.::.| |.|::|
Zfish   250 FYKLLQGADLWLMRVDFVFEFP-RPTMPNIIYTGGFQCTPT-KPLPHDLEDFMQSSGDHGVIVMS 312

  Fly   307 LGSNVKGSHINPDTV-VKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIK 370
            |||.:.   :.||.| .::....::|.|:|||::.. :|.....:|.....|:||.|:|.||..|
Zfish   313 LGSFIS---VLPDYVSSEIAAAFARLPQKVIWRYTG-KKPSTLGNNTLLVDWMPQKDLLGHPKTK 373

  Fly   371 LFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILS 435
            |||.|.|..|:.||.|||.|::.:|.|.||..|...:..:|.....||..|.|.....||.|:::
Zfish   374 LFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGENSLHAAIQEVIN 438

  Fly   436 NPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAV 500
            .|.|...:...|.|:||:|:...:|.|:|.|:|:||.|||||::....|.:.:.:::|:...:..
Zfish   439 EPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVSVTLIA 503

  Fly   501 VLVILVLLLKLLLQFIYRKIFAKPKK 526
            |::|.:..:.:.::::..|..::.:|
Zfish   504 VVLIFIYSMFVTVRYLCIKCCSRKRK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	145/508 (29%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	145/531 (27%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	86/245 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.840