DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt37A2 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	511	Identity:	141/511 - (27%)
Similarity:	247/511 - (48%)	Gaps:	33/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 SHLIIQMSTAKVLAERGHNVTVIT-VLKPVVNHK-----NITVIMVPLTKEESQQM-SDTIGA-M 92
            ||.....:..:.|.:|.|:|||:. ...|.|.|.     :..|..|.:.|||:..: ||.|.. |
Zfish    31 SHWHNMRAIIEALVDRNHSVTVLVGSSSPTVPHTQKARFDYHVFKVNIEKEEADAVWSDFIYLWM 95

  Fly    93 SKTDNS-NMILSMLRMMGQMEFMFDKMA-GALKDDRVRDLYLNRDNKFDLVLSGYFMNVYQLGFA 155
            ::|... ..:.::.::|.:...:.|::. |..|:|.::.|   |::.:|::.|...|....| .|
Zfish    96 NETATKYETVSNIFQVMSRFMTLTDEVCKGMFKEDLLQML---RESHYDVLFSDPMMPCSDL-MA 156

  Fly   156 KKVKAPVIVVATMPPNQLLNPLIGN-PLEIAYVPSISDSVEKGKGMSFRQR----LAGYSSSFFF 215
            :.:..|:::............:.|. |...:|||:.|........|||.:|    |..:|...||
Zfish   157 QTLNIPLVLSLRATFAYSFERMCGQMPAPPSYVPAASLRDHLTDRMSFMERVENMLLYFSHDVFF 221

  Fly   216 GIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFFASHAPSEGPIRPNVPAAIEIGGIQV 280
            .::...|   ..|:|.|:.|....|   .|.:....:....::...|.| ||..|....:||:..
Zfish   222 KLYMMFT---FDRIYTEIRGKPTTM---CETMGKADIWLIRTYWDFEYP-RPFPPNFKFVGGLHC 279

  Fly   281 KDTPDPLPQNMAEFLGNATD-GAILLSLGSNVKGSHINPDTVVKMFNVLSKLKQRVIWKWEDLEK 344
            |.. .||.:.|.||:.::.| |.::.||||.:|  ::..:....:...|.::.|:|:|::..  |
Zfish   280 KPA-KPLSKEMEEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSG--K 339

  Fly   345 TPGK-SDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGKPMLSLPVFGDQPGNADVMV 408
            ||.. :.|.....|:||:|:|.||..|.||.|.|..|:.||.|||.||:.||:|.|||.|...|.
Zfish   340 TPETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMK 404

  Fly   409 KQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRPMSARESVIYWTEYVIRHHG 473
            .:|..:...:.:||.:...:|:..:|:||.|.:.:...|.::.|:||...:..:||.|:|:|:.|
Zfish   405 TKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKG 469

  Fly   474 AAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFIYRKIFAKPKKEKK 529
            |.||:.....:|:...:.:|:.|.:..:..::..|......|::|:...|.:.|:|
Zfish   470 AKHLRVQAHELSWYQYHCLDVAAFLLSIAALITFLWVKACCFLFRRCVRKTRPERK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	133/470 (28%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	138/503 (27%)
		REC	<129..>178	CDD:302758	9/52 (17%)
		egt	<254..485	CDD:223071	78/236 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585054
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930