Protein Alignment DNApol-theta and SGS1

DIOPT Version :9

• Sequence 1: NP_524333.1
• Gene: DNApol-theta / 41571
• FlyBaseID: FBgn0002905
• Length: 2059
• Species: Drosophila melanogaster
• Sequence 2: NP_013915.1
• Gene: SGS1 / 855228
• SGDID: S000004802
• Length: 1447
• Species: Saccharomyces cerevisiae
• Alignment Length: 1426
• Identity: 242/1426 - (16%)
• Similarity: 451/1426 - (31%)
• Gaps: 569/1426 - (39%)

  Fly    18 EKGMQADDKENAQPGNGNIQVQSAGNEVNSEIQEINSEFFRDEFSYEVNQAHKPAE--------- 73
            |..|:|:|           ...|:......|.:|.|....:.:|.:.||....|.:
Yeast   408 ELTMEAED-----------DAHSSYMTTRDEEKEENELLNQSDFDFVVNDDLDPTQDTDYHDNMD 461

  Fly    74 --------------QSVVNVSQVQQHMAVVSNQDSEDQSRSSALNDQICTQS-SFEGEDAGADAV 123
                          :|.:.:||.:....::|:..:  ||..|...:||..:. ....:|...||:
Yeast   462 VSANIQESSQEGDTRSTITLSQNKNVQVILSSPTA--QSVPSNGQNQIGVEHIDLLEDDLEKDAI 524

  Fly   124 LDQPNLDENSFLCPAQ-------------DEEASEQLKEDILHSHSVLAKQEFYQEISQVTQNLS 175
            ||    |..||....|             .|:.:|..:||..::..........:...:..:|.:
Yeast   525 LD----DSMSFSFGRQHMPMSHSDLELIDSEKENEDFEEDNNNNGIEYLSDSDLERFDEERENRT 585

  Fly   176 SMS-----PNQLRV-----------------SPNSSRIREAM---PERPAMPLDLNTLRSISAWN 215
            .::     .|.|::                 ||...|.:.::   .|......|.:....:|..|
Yeast   586 QVADIQELDNDLKIITERKLTGDNEHPPPSWSPKIKREKSSVSQKDEEDDFDDDFSLSDIVSKSN 650

  Fly   216 L---------PMSIQAEYKKKGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILML 271
            |         |.|.:..|:...|..:..::...|.......:..::....||..||:|..:   |
Yeast   651 LSSKTNGPTYPWSDEVLYRLHEVFKLPGFRPNQLEAVNATLQGKDVFVLMPTGGGKSLCYQ---L 712

  Fly   272 KTVLERGK---KVLLILPFISVVREKMFYMQDLLTPAG-YRVEG-----------FYGG-----Y 316
            ..|::.||   ..::|.|.||::::::.::.:....|. :...|           |..|     |
Yeast   713 PAVVKSGKTHGTTIVISPLISLMQDQVEHLLNKNIKASMFSSRGTAEQRRQTFNLFINGLLDLVY 777

  Fly   317 TPPGGFESLHVAICTIEKANSIVNKLMEQGKLETIGMVVVDEVHLISDKGRGYILELLLAKILYM 381
            ..|       ..|...|:....:::|...|||   ..:||||.|.:|:.|..:..:.   |.|..
Yeast   778 ISP-------EMISASEQCKRAISRLYADGKL---ARIVVDEAHCVSNWGHDFRPDY---KELKF 829

  Fly   382 SRRNGLQIQVITMSAT---------LENVQLLQSWLDAELYITNYRPVALKEMIKVGTVIYDHRL 437
            .:|....|.:|.::||         :.|::|.:             ||.||:..        :|.
Yeast   830 FKREYPDIPMIALTATASEQVRMDIIHNLELKE-------------PVFLKQSF--------NRT 873

  Fly   438 KLVRDVAKQKVLLKGLENDSDDVALLC--IETLLEGCSVIVFCPSKDWCENLAVQLATAIHVQIK 500
            .|..:|.|:         ..:.:..:|  :::..:..:.|::|.||..||..:.|:
Yeast   874 NLYYEVNKK---------TKNTIFEICDAVKSRFKNQTGIIYCHSKKSCEQTSAQM--------- 920

  Fly   501 SETVLGQRLRTNLNPRAIAEVKQQLRDIPTGLDGVMSKAITYACAFHHAGLTTEERDIIEASFKA 565
                  ||                        :|:       .||::|||:..:||..::.:::|
Yeast   921 ------QR------------------------NGI-------KCAYYHAGMEPDERLSVQKAWQA 948

  Fly   566 GALKVLVATSTLSSGVNLPARRVL----IRSPLFGGKQMSSLTYRQMIGRAGRMG---------- 616
            ..::|:.||.....|::.|..|.:    :...|.|        |.|..|||||.|
Yeast   949 DEIQVICATVAFGMGIDKPDVRFVYHFTVPRTLEG--------YYQETGRAGRDGNYSYCITYFS 1005

  Fly   617 -KDTLGESILICNEINA-RMGRDLVVSELQPITS-CLDMDGSTHLKRALLEVISSGVANTKEDID 678
             :|......:|..:.|. |..::..:::||.:.: |   |..|..:|.|:      ::...||.|
Yeast  1006 FRDIRTMQTMIQKDKNLDRENKEKHLNKLQQVMAYC---DNVTDCRRKLV------LSYFNEDFD 1061

  Fly   679 FFVNCTLLSAQKAFHAKEKPPDE-ESDANYINDALDFLVEYEFVRLQRNEERETAVYVATRLGAA 742
                      .|..|   |..|. .:.||.|                 ||||:
Yeast  1062 ----------SKLCH---KNCDNCRNSANVI-----------------NEERD------------ 1084

  Fly   743 CLASSMPPTDGLILFAELQKSRRSFVLESELHAVYLVTPYSVCYQLQDIDWLLYVHMWEKLSSPM 807
                                                                        ::.|.
Yeast  1085 ------------------------------------------------------------VTEPA 1089

  Fly   808 KKVGELVGVRDAFLYKALRGQTKLDYKQMQIHKRFYIALALEELVNETPINVVVHKYKCHRGMLQ 872
            ||:.:||                                  |.:.||.
Yeast  1090 KKIVKLV----------------------------------ESIQNER----------------- 1103

  Fly   873 SLQQMASTFAGIVTAFCNSLQWSTLALIVSQFKDRLFFGIHRDLIDLMRIPDLSQKRARALFDAG 937
                       :...:|                        :|:....|...:.|.....|.:.|
Yeast  1104 -----------VTIIYC------------------------QDVFKGSRSSKIVQANHDTLEEHG 1133

  Fly   938 ITSLVELAGADPVELEKVLYNSISFDSAKQHDHENADEAAKRNVVRNFYITGKAGMTVS------ 996
            |...::.:     |:|::.::.|:.                 .|::.:.|...:|...|
Yeast  1134 IGKSMQKS-----EIERIFFHLITI-----------------RVLQEYSIMNNSGFASSYVKVGP 1176

  Fly   997 EAAKLLIGEARQFVQHEIGLGTIKWTQTQAGVEIASRAIHDGGEVDLHMSLEEEQPPVKRKLSIE 1061
            .|.|||.|:                      :||         ::...:|....:|      |..
Yeast  1177 NAKKLLTGK----------------------MEI---------KMQFTISAPNSRP------STS 1204

  Fly  1062 ENGTANSQKNPRLETVVDTQRGYKVDKNIANQSKMNPNLKEIDAQNKARR----NSTAHMDNLNP 1122
            .:..||....|     |..|:...:..|:|    .||. :.|.|:...|.    .||  |.:.:|
Yeast  1205 SSFQANEDNIP-----VIAQKSTTIGGNVA----ANPP-RFISAKEHLRSYTYGGST--MGSSHP 1257

  Fly  1123 ISNDPCQNNVNVKTAQPIISNLNDIQKQGSQIEKMKINPATVVCSPQLANEEKPSTS----QSAR 1183
            |:   .:|..::::.|    .||:::....::.::.:|         |.|...|...    .|..
Yeast  1258 IT---LKNTSDLRSTQ----ELNNLRMTYERLRELSLN---------LGNRMVPPVGNFMPDSIL 1306

  Fly  1184 RKL-----VNE------GMAE---RRRVALMKI------QQRTQKENQSKDQPIQASRSNQLSSP 1228
            :|:     :|:      |..|   |||....|.      ::|:.::::..|..:.....|:.::.
Yeast  1307 KKMAAILPMNDSAFATLGTVEDKYRRRFKYFKATIADLSKKRSSEDHEKYDTILNDEFVNRAAAS 1371

  Fly  1229 VNRTPANRWTQS-----------ENPN--NEMNNSQLPRRNPRNQSPVPNANRTASRKVSN 1276
            .|....:..|:|           ||..  |::..||||:....::|...:.:: :|:|.:|
Yeast  1372 SNGIAQSTGTKSKFFGANLNEAKENEQIINQIRQSQLPKNTTSSKSGTRSISK-SSKKSAN 1431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125	135/826 (16%)
		DEAD	251..404	CDD:278688	40/181 (22%)
		HELICc	542..616	CDD:197757	23/77 (30%)
		PolA	1489..2055	CDD:223820
		DNA_pol_A_theta	1668..2053	CDD:176475
SGS1	NP_013915.1	RecQ	670..1350	CDD:223588	178/1063 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910