DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-theta and Polg

DIOPT Version :9

Sequence 1:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	XP_008757783.1	Gene:	Polg / 85472	RGDID:	620057	Length:	1223	Species:	Rattus norvegicus

Alignment Length:	1329	Identity:	238/1329 - (17%)
Similarity:	384/1329 - (28%)	Gaps:	546/1329 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1120 LNPISNDPCQNNVNVKTAQPIISNLNDIQKQGSQIEKMKINPATVV------------CSPQLAN 1172
            |:|:.:|          .||      ..|...|:..::::||..:.            |...:.:
  Rat    31 LDPVPSD----------GQP------QSQMPSSENGQLRLNPLHIQMLSRGLHEQIFGCGGDVPD 79

  Fly  1173 EEKPSTSQSARRKLVNEGMAERRRVALMKIQQRTQK-ENQSKDQPIQASRSNQLSSPVNRTPANR 1236
            |.....|....||   .|:..:....|..:|.|..: ...:.||..:.....| |.|.....|:
  Rat    80 EAAVQRSIEHLRK---HGLWGQPTTPLPDVQLRLPRLFGGNLDQHFRLLAQKQ-SLPYLEAAAS- 139

  Fly  1237 WTQSENPNNEMNNSQLP-------------RRNPRNQSPVPNANRTASRKVSNAEEDLFMADDSF 1288
                      ::.:|||             |..|..:          :..|:..||...:.|...
  Rat   140 ----------LSEAQLPPQPRKWVWAEGWTRYGPEGE----------AEPVAIPEERALVFDVEV 184

  Fly  1289 MLNTGLAAALTAAESKIA------------------SCTEADVIP---------SSQP--KEPEV 1324
            .|..|....|..|.|..|                  ..:.||:||         |:|.  :|..|
  Rat   185 CLAEGTCPTLAVAISPSAWYSWCSRRLVEERYSWTSQLSPADLIPLGVSASASSSTQQDWQEQLV 249

  Fly  1325 IGALTPH----------------ASRLKRSDQL-------------RS---------QRIQSPSP 1351
            :|    |                .||::..|.:             ||         .:.|.|:.
  Rat   250 VG----HNVSFDRAHIREQYLIQGSRMRFLDTMSMHMAISGLSSFQRSLWMGAKQGKHKTQHPTK 310

  Fly  1352 TPQREIEIDLESKNESNG--VSSMEISDMSMEN-------------PLMKNPLHLNASHIMSCSK 1401
            ..|:       |:..:||  :||.:..|:|..|             .|.|.|..|.....|.
  Rat   311 RGQK-------SQKNANGPAISSWDWMDISSANNLADVHNLYVGGPRLAKEPRELFVKGSMR--- 365

  Fly  1402 VDETASSFSSIDIIDVCGHR-----NAFQAAI----------IEINNATRLGFSVGLQAQAGKQK 1451
              :...:|.  |:::.|...     ..||..:          :.:.....:|.|.
  Rat   366 --DIRENFQ--DLMEYCARDVWATFEVFQQQLPLFLERCPHPVTLAGMLEMGVSY---------- 416

  Fly  1452 PLIGSNLLINQ------VAAAENREAAARE--RVLFQV--DDTNFISGVSFCLADNVAYY----- 1501
                  |.:||      ..|....|...||  :.|.::  |....:||.|  |.|.:..|
  Rat   417 ------LPVNQNWERYLTEAQSTYEELQREMKKSLMELANDACQLLSGES--LVDWLYRYKEDPW 473

  Fly  1502 -WNMQID-----------------------ERAAYQGVP-------TPLKVQEL-CNLMARKDLT 1534
             |:::.|                       |.|...|.|       .|.:.:|| .|:||
  Rat   474 LWDLEWDLQEFKQKKAKKVKKTASASKLPIEGAGPFGDPMDQEDPGPPSEEEELQQNIMA----- 533

  Fly  1535 LVMHDGKEQLKMLRKAIPQ-----------LKRISAKLEDAKVANWLLQPDKTVNFLNMCQTFAP 1588
               |...:|||.....:|:           .:::..:|:|..   |...|    :.|::.....|
  Rat   534 ---HTRLQQLKSTTDLLPKRPQHLPGHPGWYRKLCPRLDDPA---WTPGP----SLLSLQMRVTP 588

  Fly  1589 ECTGLA------NLCGS-GRGYSSYGLDTSSAILPRIRT-----------AIESCVTLHIL-QGQ 1634
            :...|.      :...| |.||...|...:...||...|           ||||....|.| ||:
  Rat   589 KLMALTWDGFPLHYSDSHGWGYLVPGRRDNLTELPVSPTEESAAVTCPYRAIESLYRRHCLDQGK 653

  Fly  1635 TENLSRIGNGDLLKFFHDIEMPIQLTLCQMELVGFPA----QKQRLQQLYQRMVAVMKKVETKIY 1695
            .:..::  ..||.:.|...:..:..|:.::..:...|    :...|.|......|...|.....|
  Rat   654 QQLETQ--ETDLAEEFLLTDSAMWQTVEELGCLDVEAEATVESSGLSQPLVPPTACAPKTSQPTY 716

  Fly  1696 ---------------------EQHGSRFNLGSSQA--------------------------VAKV 1713
                                 .:.|:.:|:||..|                          :.|:
  Rat   717 HHGNGPYNDVDIPGCWFFKLPHKDGNNYNVGSPFAKDFLPKMEDGTLQAGPGGARGPRALEINKM 781

  Fly  1714 LGLHRKAKGRVTTSRQVLEKLNSPISHLILGYRKLSGLLAKSIQPLMECCQADRIHGQSITY-TA 1777
            :...|.|..|: :|:.|:....|.:...:..:....           |......|..|.:|. |.
  Rat   782 ISFWRNAHKRI-SSQMVVWLPRSALPRAVTRHPSFD-----------EESHYGAILPQVVTAGTI 834

  Fly  1778 TGRISMTEPNLQNVAKEFSIQVGSDVVHISCRSPFMPTDESRCLLSADFCQLEMRILAHMSQDKA 1842
            |.|  ..||.....:.....:|||                            |::.:........
  Rat   835 TRR--AVEPTWLTASNARPDRVGS----------------------------ELKAMVQAPPGYV 869

  Fly  1843 LLEVMKSSQDLFIAIA---AH-----------WNKIE--ESEVTQDLRNST-----------KQV 1880
            |:.....||:|:||..   ||           |..::  :|..| ||.:.|           |..
  Rat   870 LVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGT-DLHSKTAATVGISREHAKVF 933

  Fly  1881 CYGIVYGMGMRSLAESL------NCSEQEARMISDQFHQAYKGIRDY--------TTRVVNFARS 1931
            .||.:||.| :|.||.|      ..|.|||...:.|.:...||:|.|        ..:.:|....
  Rat   934 NYGRIYGAG-QSFAERLLMQFNHRLSRQEAADKAQQMYAVTKGLRRYRLSDDGEWLVKQLNVPVD 997

  Fly  1932 K---GFV---------------------ETITGRR----------RYLENI-NSDVEH------- 1954
            :   |:|                     |.:|.|.          ..||:| .||...
  Rat   998 RTEDGWVSLQDLRKIRREASRKSRWKKWEVVTERAWTGGTESEMFNKLESIAMSDTPRTPVLGCC 1062

  Fly  1955 ---------LKNQAERQAVNSTIQGSAADIAKNAILKME------------------------KN 1986
                     ::.:.....||..:|.||.|.....::.|:                        :.
  Rat  1063 ISRALEPSVVQGEFMTSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVRE 1127

  Fly  1987 IERYRE-----------------KLALGD--------NSVDLVMHLHDELIFE------------ 2014
            .:|||.                 ||.|.|        ::||:...|..|:..:
  Rat  1128 EDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDQCLRKEVTMDCKTPSNPTGMER 1192

  Fly  2015 ---VPTGKAKKIAKVLSLTMENCVKLSVP 2040
               :|.|:|..|.:::.||..:..|.|.|
  Rat  1193 KYGIPQGEALDIYQIIELTKGSLEKRSQP 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125
		DEAD	251..404	CDD:278688
		HELICc	542..616	CDD:197757
		PolA	1489..2055	CDD:223820	151/827 (18%)
		DNA_pol_A_theta	1668..2053	CDD:176475	102/581 (18%)
Polg	XP_008757783.1	DnaQ_like_exo	<248..>280	CDD:299142	6/35 (17%)
		DNA_pol_A	413..>455	CDD:295402	11/57 (19%)
		DNA_pol_gammaA	772..1187	CDD:176478	82/458 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900