Protein Alignment PolQ and MIP1

DIOPT Version :10

• Sequence 1: NP_524333.1
• Gene: PolQ / 41571
• FlyBaseID: FBgn0002905
• Length: 2059
• Species: Drosophila melanogaster
• Sequence 2: NP_014975.2
• Gene: MIP1 / 854508
• SGDID: S000005857
• Length: 1254
• Species: Saccharomyces cerevisiae
• Alignment Length: 1075
• Identity: 199/1075 - (18%)
• Similarity: 350/1075 - (32%)
• Gaps: 429/1075 - (39%)

  Fly  1221 RSNQLSSPVNRTPAN-----RWTQSENPNNEMNNSQLPRRNPRNQSPVPNANRTASRKV---SNA 1277
            ||..:...|.|.|..     ||..::.     |.::.||.||..   :.....:..|:|   ...
Yeast     7 RSECMLRMVRRRPLRVQFCARWFSTKK-----NTAEAPRINPVG---IQYLGESLQRQVFGSCGG 63

  Fly  1278 EEDLFMADDSFMLNT------GLAAALTAAESKIASCTEADVIPSSQPKEPEVIGALTPHASRLK 1336
            ::::..:|....|:.      ||....|....           |.|.|..|....:|..|..::.
Yeast    64 KDEVEQSDKLMELSKKSLKDHGLWGKKTLITD-----------PISFPLPPLQGRSLDEHFQKIG 117

  Fly  1337 R--SDQLRS--------------QRIQSP---------SPT----PQREIEI-DLESKNESNGVS 1371
            |  |:..:|              :.::.|         :|.    |..|:.: |:|        :
Yeast   118 RFNSEPYKSFCEDKFTEMVARPAEWLRKPGWVKYVPGMAPVEVAYPDEELVVFDVE--------T 174

  Fly  1372 SMEISDMSMENPLMKNPLHLNASHIMSCSKVDETASSFSSIDIIDVCGHRNAFQAAIIEINNATR 1436
            ...:||.    |.:...|...|.::. ||..              :||..:  .||:|.:|.
Yeast   175 LYNVSDY----PTLATALSSTAWYLW-CSPF--------------ICGGDD--PAALIPLNT--- 215

  Fly  1437 LGFSVGLQAQAGKQKPLIGSNLLINQVAAAENREAAARERVLFQVDDTNFISGVSFCLADNVAYY 1501
                      ..|::.:||.|:            |..|.|||   ::.||        .|:.|::
Yeast   216 ----------LNKEQVIIGHNV------------AYDRARVL---EEYNF--------RDSKAFF 247

  Fly  1502 WNMQIDERAAYQGVPTPLKVQELCNLMARKDLTLVMHDGKEQLKMLRKAIPQLK---------RI 1557
            .:.|....|::             .|.:|:....:.::.|::.::..:..|::.         .:
Yeast   248 LDTQSLHIASF-------------GLCSRQRPMFMKNNKKKEAEVESEVHPEISIEDYDDPWLNV 299

  Fly  1558 SA--KLEDAKVANWLLQPDKT--------------VNF---LNMCQT---------------FAP 1588
            ||  .|:|....:..:..|||              .||   :|.|.|               |..
Yeast   300 SALNSLKDVAKFHCKIDLDKTDRDFFASTDKSTIIENFQKLVNYCATDVTATSQVFDEIFPVFLK 364

  Fly  1589 EC------TGLANL--C---GSGRGYSSYGLDTSSAILPRIRTAIESCVTLHILQGQTENLSRIG 1642
            :|      .||.:|  |   .....::.| |::|.::..:.:..|||.: :.|::...
Yeast   365 KCPHPVSFAGLKSLSKCILPTKLNDWNDY-LNSSESLYQQSKVQIESKI-VQIIKDIV------- 420

  Fly  1643 NGDLLKFFHDIEM-------------PIQLT------LCQMELVGFPAQKQRLQQLYQRMVAVMK 1688
               |||...|..:             |::||      .|| :|.|||       :.|:::.....
Yeast   421 ---LLKDKPDFYLKDPWLSQLDWTTKPLRLTKKGVPAKCQ-KLPGFP-------EWYRQLFPSKD 474

  Fly  1689 KVETKI----------------------YEQHGSRFNLGSSQAVAKVLGLHRKAKGRV---TTSR 1728
            .||.||                      .::.|..||:...|...      .|||..|   :.|:
Yeast   475 TVEPKITIKSRIIPILFKLSWENSPVIWSKESGWCFNVPHEQVET------YKAKNYVLADSVSQ 533

  Fly  1729 Q---------------VLEKL---NSPISHLILGYRKLSGLLAKSIQPLME----CCQADRIHGQ 1771
            :               ||.|:   |.|..:       .:.||.||.....|    ..:::..| |
Yeast   534 EEEEIRTHNLGLQCTGVLFKVPHPNGPTFN-------CTNLLTKSYNHFFEKGVLKSESELAH-Q 590

  Fly  1772 SITYTATGRISMTEPNLQNVAKEFSIQVGSDVVHISCRSPFMPTDESRCLLSADFCQLE------ 1830
            ::...::|...|:       |:|   ::.|..|..||:.|    :|.:.|.:......|
Yeast   591 ALQINSSGSYWMS-------ARE---RIQSQFVVPSCKFP----NEFQSLSAKSSLNNEKTNDLA 641

  Fly  1831 --------MRILAHMSQDKALLEVMKS---------------------------SQDLFIA---- 1856
                    |..:...:.:.|.|....:                           |::|:||
Yeast   642 IIIPKIVPMGTITRRAVENAWLTASNAKANRIGSELKTQVKAPPGYCFVGADVDSEELWIASLVG 706

  Fly  1857 ---------IAAHWNKIE--ESEVTQDLRNSTKQV--C---------YGIVYGMGMRSLAESL-- 1897
                     .|..|..:|  ::|.| ||...|.|:  |         ||.:||.|.:..::.|
Yeast   707 DSIFNVHGGTAIGWMCLEGTKNEGT-DLHTKTAQILGCSRNEAKIFNYGRIYGAGAKFASQLLKR 770

  Fly  1898 ---NCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSK-------GFVETITGRRRYLENINSDV 1952
               :.:::|.:.|:::.::..||         ...|||       |..|:|...:  ||:| ::.
Yeast   771 FNPSLTDEETKKIANKLYENTKG---------KTKRSKLFKKFWYGGSESILFNK--LESI-AEQ 823

  Fly  1953 EHLK-------------------NQAERQAVNSTIQGSAADIAKNAILKMEKNIERYREKLALGD 1998
            |..|                   |......:|..||.|..|........||..|::|       :
Yeast   824 ETPKTPVLGCGITYSLMKKNLRANSFLPSRINWAIQSSGVDYLHLLCCSMEYIIKKY-------N 881

  Fly  1999 NSVDLVMHLHDELIFEVPTGKAKKIAKVLSLTMEN 2033
            ....|.:.:|||:.|.|  .:..|....::|.:.|
Yeast   882 LEARLCISIHDEIRFLV--SEKDKYRAAMALQISN 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolQ	NP_524333.1	BRR2	216..779	CDD:440817
		DNA_pol_A_theta	1668..2053	CDD:176475	98/511 (19%)
MIP1	NP_014975.2	DNApol_Exo	95..362	CDD:465664	59/355 (17%)
		DNA_pol_gammaA	581..960	CDD:176478	71/371 (19%)