DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-theta and MIP1

DIOPT Version :9

Sequence 1:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_014975.2	Gene:	MIP1 / 854508	SGDID:	S000005857	Length:	1254	Species:	Saccharomyces cerevisiae

Alignment Length:	1075	Identity:	199/1075 - (18%)
Similarity:	350/1075 - (32%)	Gaps:	429/1075 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1221 RSNQLSSPVNRTPAN-----RWTQSENPNNEMNNSQLPRRNPRNQSPVPNANRTASRKV---SNA 1277
            ||..:...|.|.|..     ||..::.     |.::.||.||..   :.....:..|:|   ...
Yeast     7 RSECMLRMVRRRPLRVQFCARWFSTKK-----NTAEAPRINPVG---IQYLGESLQRQVFGSCGG 63

  Fly  1278 EEDLFMADDSFMLNT------GLAAALTAAESKIASCTEADVIPSSQPKEPEVIGALTPHASRLK 1336
            ::::..:|....|:.      ||....|....           |.|.|..|....:|..|..::.
Yeast    64 KDEVEQSDKLMELSKKSLKDHGLWGKKTLITD-----------PISFPLPPLQGRSLDEHFQKIG 117

  Fly  1337 R--SDQLRS--------------QRIQSP---------SPT----PQREIEI-DLESKNESNGVS 1371
            |  |:..:|              :.::.|         :|.    |..|:.: |:|        :
Yeast   118 RFNSEPYKSFCEDKFTEMVARPAEWLRKPGWVKYVPGMAPVEVAYPDEELVVFDVE--------T 174

  Fly  1372 SMEISDMSMENPLMKNPLHLNASHIMSCSKVDETASSFSSIDIIDVCGHRNAFQAAIIEINNATR 1436
            ...:||.    |.:...|...|.::. ||..              :||..:  .||:|.:|.
Yeast   175 LYNVSDY----PTLATALSSTAWYLW-CSPF--------------ICGGDD--PAALIPLNT--- 215

  Fly  1437 LGFSVGLQAQAGKQKPLIGSNLLINQVAAAENREAAARERVLFQVDDTNFISGVSFCLADNVAYY 1501
                      ..|::.:||.|:            |..|.|||   ::.||        .|:.|::
Yeast   216 ----------LNKEQVIIGHNV------------AYDRARVL---EEYNF--------RDSKAFF 247

  Fly  1502 WNMQIDERAAYQGVPTPLKVQELCNLMARKDLTLVMHDGKEQLKMLRKAIPQLK---------RI 1557
            .:.|....|::             .|.:|:....:.::.|::.::..:..|::.         .:
Yeast   248 LDTQSLHIASF-------------GLCSRQRPMFMKNNKKKEAEVESEVHPEISIEDYDDPWLNV 299

  Fly  1558 SA--KLEDAKVANWLLQPDKT--------------VNF---LNMCQT---------------FAP 1588
            ||  .|:|....:..:..|||              .||   :|.|.|               |..
Yeast   300 SALNSLKDVAKFHCKIDLDKTDRDFFASTDKSTIIENFQKLVNYCATDVTATSQVFDEIFPVFLK 364

  Fly  1589 EC------TGLANL--C---GSGRGYSSYGLDTSSAILPRIRTAIESCVTLHILQGQTENLSRIG 1642
            :|      .||.:|  |   .....::.| |::|.::..:.:..|||.: :.|::...
Yeast   365 KCPHPVSFAGLKSLSKCILPTKLNDWNDY-LNSSESLYQQSKVQIESKI-VQIIKDIV------- 420

  Fly  1643 NGDLLKFFHDIEM-------------PIQLT------LCQMELVGFPAQKQRLQQLYQRMVAVMK 1688
               |||...|..:             |::||      .|| :|.|||       :.|:::.....
Yeast   421 ---LLKDKPDFYLKDPWLSQLDWTTKPLRLTKKGVPAKCQ-KLPGFP-------EWYRQLFPSKD 474

  Fly  1689 KVETKI----------------------YEQHGSRFNLGSSQAVAKVLGLHRKAKGRV---TTSR 1728
            .||.||                      .::.|..||:...|...      .|||..|   :.|:
Yeast   475 TVEPKITIKSRIIPILFKLSWENSPVIWSKESGWCFNVPHEQVET------YKAKNYVLADSVSQ 533

  Fly  1729 Q---------------VLEKL---NSPISHLILGYRKLSGLLAKSIQPLME----CCQADRIHGQ 1771
            :               ||.|:   |.|..:       .:.||.||.....|    ..:::..| |
Yeast   534 EEEEIRTHNLGLQCTGVLFKVPHPNGPTFN-------CTNLLTKSYNHFFEKGVLKSESELAH-Q 590

  Fly  1772 SITYTATGRISMTEPNLQNVAKEFSIQVGSDVVHISCRSPFMPTDESRCLLSADFCQLE------ 1830
            ::...::|...|:       |:|   ::.|..|..||:.|    :|.:.|.:......|
Yeast   591 ALQINSSGSYWMS-------ARE---RIQSQFVVPSCKFP----NEFQSLSAKSSLNNEKTNDLA 641

  Fly  1831 --------MRILAHMSQDKALLEVMKS---------------------------SQDLFIA---- 1856
                    |..:...:.:.|.|....:                           |::|:||
Yeast   642 IIIPKIVPMGTITRRAVENAWLTASNAKANRIGSELKTQVKAPPGYCFVGADVDSEELWIASLVG 706

  Fly  1857 ---------IAAHWNKIE--ESEVTQDLRNSTKQV--C---------YGIVYGMGMRSLAESL-- 1897
                     .|..|..:|  ::|.| ||...|.|:  |         ||.:||.|.:..::.|
Yeast   707 DSIFNVHGGTAIGWMCLEGTKNEGT-DLHTKTAQILGCSRNEAKIFNYGRIYGAGAKFASQLLKR 770

  Fly  1898 ---NCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSK-------GFVETITGRRRYLENINSDV 1952
               :.:::|.:.|:::.::..||         ...|||       |..|:|...:  ||:| ::.
Yeast   771 FNPSLTDEETKKIANKLYENTKG---------KTKRSKLFKKFWYGGSESILFNK--LESI-AEQ 823

  Fly  1953 EHLK-------------------NQAERQAVNSTIQGSAADIAKNAILKMEKNIERYREKLALGD 1998
            |..|                   |......:|..||.|..|........||..|::|       :
Yeast   824 ETPKTPVLGCGITYSLMKKNLRANSFLPSRINWAIQSSGVDYLHLLCCSMEYIIKKY-------N 881

  Fly  1999 NSVDLVMHLHDELIFEVPTGKAKKIAKVLSLTMEN 2033
            ....|.:.:|||:.|.|  .:..|....::|.:.|
Yeast   882 LEARLCISIHDEIRFLV--SEKDKYRAAMALQISN 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125
		DEAD	251..404	CDD:278688
		HELICc	542..616	CDD:197757
		PolA	1489..2055	CDD:223820	141/763 (18%)
		DNA_pol_A_theta	1668..2053	CDD:176475	98/511 (19%)
MIP1	NP_014975.2	DNApol_Exo	95..362	CDD:407968	59/355 (17%)
MIP1	NP_014975.2	DNA_pol_gammaA	581..960	CDD:176478	71/371 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900