DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-theta and l(3)72Ab

DIOPT Version :9

Sequence 1:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_648818.3	Gene:	l(3)72Ab / 39737	FlyBaseID:	FBgn0263599	Length:	2142	Species:	Drosophila melanogaster

Alignment Length:	2331	Identity:	439/2331 - (18%)
Similarity:	829/2331 - (35%)	Gaps:	771/2331 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ALEKGMQA--DDKENAQPGNGNIQVQSAGNEVNSE------------IQEINSEFFRDEFSYEVN 66
            |.::|.:|  |...:|:    |:..:.|.|.|..|            :|...|:|::|..   |:
  Fly   230 AQDEGEEARIDHTLHAE----NLANEEAANNVKKERSLHPLDIDAYWLQRCLSKFYKDAM---VS 287

  Fly    67 QAHKPAE-----QSVVNVSQVQQHMAVVSNQDSEDQSRSSALNDQI---CTQSSFEGEDAGADAV 123
            |: |.|:     :...:....:..:.::...|..|..:...||.|:   ||..:....|:....:
  Fly   288 QS-KAADVLKILKDAADDRDCENQLVLLLGYDCFDFIKQLKLNRQMVLYCTMLASAQTDSERQRI 351

  Fly   124 LDQPNLDENSFLC---------PAQDEE-----ASEQLKEDILHSHSVLA------KQEFYQEIS 168
            .::  :..||.|.         .::|:|     .|::.|.|.....:..|      :|....|..
  Fly   352 REK--MRGNSALAKILRQLDTGKSEDQEEGEARGSKRGKGDAEDGGAAAAGQVAGVRQLLELEEM 414

  Fly   169 QVTQNLSSMSPNQLRVSPNSSRIREA------MPERPAMPLDLN-TLRSISAWNLPMSIQAEYKK 226
            ..||....|:..:.::...|.|.:..      :|....:|.|.| .|:.:.  .||..:|..::.
  Fly   415 AFTQGSHFMANKRCQLPDGSYRKQRKGYEEVHVPALKPVPFDANEELQPVD--KLPKYVQPVFEG 477

  Fly   227 KGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLK----------TVLERGKKV 281
            ...::....:   |.|..|..:. |::..|||.||||.|:.:.|::          |:..:..|:
  Fly   478 FKTLNRIQSR---LYKAALDSDE-NMLLCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKI 538

  Fly   282 LLILPFISVVREKMFYMQDLLTPAGYRVEGFYGGY-TPPGGFESLHVAICTIEKANSIVNKLMEQ 345
            :.:.|..|:|:|.:......|......|....|.: .......:..|.:||.||.:.|..|..|:
  Fly   539 IYVAPMKSLVQEMVGNFGRRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKGGER 603

  Fly   346 GKLETIGMVVVDEVHLISDKGRGYILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQSWLDA 410
            ..:..:.:|::||:||:.|: ||.:||.|:|:.:........:::::.:||||.|.|.:.::|..
  Fly   604 TFVSLVRLVIIDEIHLLHDE-RGPVLEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATFLRV 667

  Fly   411 E-----LYITN-YRPVAL---------KEMIKVGTVIYDHRLKLVRDVAKQKVLLKGLENDSDDV 460
            :     .|..| ||||:|         |:.:|        |.:::.::..:|.:.....|
  Fly   668 KPDKGLFYFDNSYRPVSLEQQYIGVTEKKALK--------RFQVMNEIVYEKTMEHAGRN----- 719

  Fly   461 ALLCIETLLEGCSVIVFCPSKDWCENLAVQLATAIHVQIKSETVLGQRLRT-NLNPRAIAEVKQQ 524
                        .|:||..|:    ....:.|.|:......:..||..|:. :.:...:....:|
  Fly   720 ------------QVLVFVHSR----KETGKTARAVRDMCLEQDTLGSFLKEGSASMEVLRTEAEQ 768

  Fly   525 LRDIPTGLDGVMSKAITYACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPARRVL 589
            :::..      :.:.:.|..|.||||:|..:|.::|..|....::|||:|:||:.||||||..|:
  Fly   769 VKNTE------LKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVI 827

  Fly   590 IR-----SPLFG-GKQMSSLTYRQMIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQPITS 648
            |:     :|..| ..::|:|...||:|||||...||.||.|||.|.           ||||...|
  Fly   828 IKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNH-----------SELQFYLS 881

  Fly   649 CLDMDGSTHLKRALLEVISSGVANTKEDIDFFVNCTLLSAQKAFHAKEKPPDEESDANYINDALD 713
            .|:..         |.:.|..::...:         :|:|:...          ....::.||::
  Fly   882 LLNQQ---------LPIESQFISKLPD---------MLNAEIVL----------GTVQHLQDAVN 918

  Fly   714 FL-VEYEFVRLQRN------------------EERETAVYVATRLGAACLASSMPPTDGLILFAE 759
            :| ..|.::|:.||                  :.|...::.|    |.||..|     |||.:.
  Fly   919 WLGYTYLYIRMLRNPTLYGVSHDAIKADPLLEQHRADLLHTA----ACCLERS-----GLIKYD- 973

  Fly   760 LQKSRRSFVLESELHAVYLVTPYSVCYQLQDIDWLLYVHMWEKLSSPMKKVGELVGVRDAFLYKA 824
             :|:....|.:....|.:        |.|.....|.|..:.::..|.: ::..:..:...|.:.:
  Fly   974 -RKTGHFQVTDLGRIASH--------YYLTHETMLTYNQLLKQTLSEI-ELFRVFSLSSEFRHIS 1028

  Fly   825 LRGQTKLDYKQMQIHKRFYIALALEELVNETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFC 889
            :|.:.||:               |::|:...||.:           .:|:::.::....::.|:.
  Fly  1029 VREEEKLE---------------LQKLMERVPIPI-----------KESIEEHSAKVNVLLQAYI 1067

  Fly   890 NSLQWSTLALIVSQFKDRLFFGIHRDLIDLMRIPDLSQKRARALFDAGIT-SLVELAGADPVELE 953
            :.|:....||                :.|::.|...:.:..||:|:..:| ...:||. ..:.|.
  Fly  1068 SQLKLEGFAL----------------MSDMVFITQSAARLMRAIFEIVLTRGWAQLAD-KTLTLC 1115

  Fly   954 KVLYNSI--SFDSAKQHDHENADEAAKRNVVRNFYITGKAGMTVSEAAKLLIGEARQFVQHEIG- 1015
            |::...:  |....:|. .:..||.||:...::|                ..|.......||:|
  Fly  1116 KMIDRRMWQSMTPLRQF-KKMPDEIAKKLEKKHF----------------PWGRLYDLEPHELGE 1163

  Fly  1016 ------LGTIKWTQTQAGVEIASRAIHDGGEVDLHMSLEEEQPPVKRKLSIEENGTANSQKNPRL 1074
                  ||           :...:.:|...:::|...:   ||..:..|.:|...|.:.|.:
  Fly  1164 LIRVPKLG-----------KTIHKFVHQFPKLELSTHI---QPITRGTLRVELTITPDFQWD--- 1211

  Fly  1075 ETVVDTQRGYKVDKNIANQSKMNPNLKEIDAQNKARRNSTAHMDNL---NPISNDPCQNNVNVKT 1136
            |.|.....|:.|            .::::|::      ...|.:..   ...|.|..|....|..
  Fly  1212 EKVHGQSEGFWV------------LIEDVDSE------LILHHEFFLLKQKYSQDEHQLKFFVPV 1258

  Fly  1137 AQP--------IISNLNDIQKQGSQIEKMKINPATVVCSPQLANEEKPSTSQSARRKLVNEGMAE 1193
            .:|        |:|:    :..|::.: :.::...::    |..:..|.|.
  Fly  1259 FEPLPPQYFLRIVSD----RWIGAETQ-LPVSFRHLI----LPEKNMPPTE-------------- 1300

  Fly  1194 RRRVALMKIQQRTQKENQSKDQPIQASRSNQLSSPVNRTPANRWTQSENPNNEMNNSQLPRRNPR 1258
                 |:.:|          ..||.|.|..:..|                   ..:.:.|:.||
  Fly  1301 -----LLDLQ----------PLPISALRQPKFES-------------------FYSQRFPQFNP- 1330

  Fly  1259 NQSPVPNANRTASRKVSNAEEDLFMADDSFMLNTGLAAALTAAESKIASCTEADVIPSSQPKEPE 1323
            .|:.|.||       |.|::|::|:.     ..|| :..:|.||..|
  Fly  1331 IQTQVFNA-------VYNSDENVFVG-----APTG-SGKMTIAEFAI------------------ 1364

  Fly  1324 VIGALTPHASRLKRSDQLRSQRIQSPSPTPQREIEIDLESKNESNGVSSMEISDMSMENPLMKNP 1388
                             :|....||.:    |.:.:          ||...::|:...
  Fly  1365 -----------------MRLFTTQSDA----RCVYL----------VSEEALADLVFA------- 1391

  Fly  1389 LHLNASHIMSCSKVDETASSFSSIDIIDVCGHRNAFQAAIIEINNATRLGFSVGLQAQAGKQKPL 1453
                           :..|.|.|:||            .::::...|            |....|
  Fly  1392 ---------------DWHSKFGSLDI------------KVVKLTGET------------GTDLKL 1417

  Fly  1454 IGSNLLINQVAAAENREAAARERVLFQVDDTNFISGVSFCLADNVAYYWNMQIDERAAYQGVPTP 1518
            |....|:  :..|:..:..:|.                          |..:
  Fly  1418 IAKGQLV--ITTADKWDVLSRR--------------------------WKQR------------- 1441

  Fly  1519 LKVQELCNLMARKDLTLVMHDGKEQLKMLRKAIPQLKRISAKLE-------------DAK-VANW 1569
             |..:|.||....:|.||   |.|:..:|.....:::.||:::|             ||: ||.|
  Fly  1442 -KNVQLVNLFIVDELQLV---GGEEGPVLEIVCSRMRYISSQIEKQIRIVALSASLTDARDVAQW 1502

  Fly  1570 L-LQPDKTVNFLNMCQTFAPECTGLANLCGSGRGYSSYGLDTSS-----AILPRIRTAIESCVTL 1628
            | ..|:.|.||....:....|    .::.|....:::..:.|.|     |||   :.:....|.:
  Fly  1503 LGCNPNATFNFHPSVRPIPLE----LHIQGYNVTHNATRIATMSKPVYNAIL---KYSAHKPVIV 1560

  Fly  1629 HILQGQTENLSRIGNGDLL----------KFFHDIEMPIQLTLCQM------ELV---------G 1668
            .:...:...|:.|   |:|          :|||..|..|:..|.:|      |.:         |
  Fly  1561 FVSSRKQARLTAI---DVLTYAASDLQPNRFFHAEEEDIKPFLERMTDKTLKETLAQGVAYLHEG 1622

  Fly  1669 FPAQKQRL-QQLYQR---MVAVMKK---------------VETKIY--EQHG------------- 1699
            ..|...|| :||:..   .|||:.:               ::|:.|  :.|.
  Fly  1623 LSASDHRLVEQLFDSGAVQVAVISRDLCWGMSISAHLVIIMDTQFYNGKNHSYEDYPITDVLQMI 1687

  Fly  1700 SRFNLGSSQAVAKVLGLHRKAKGRVTTSRQVLEK-LNSPI---SHLILGYRKLSGLLAKSIQPLM 1760
            .|.|..:..|.||.:.:.:.:|      :...:| :|.|:   ||  |.:|......|:.:...:
  Fly  1688 GRANRPNEDADAKCVLMCQSSK------KDFFKKFINEPLPIESH--LDHRMHDHFNAEVVTKTI 1744

  Fly  1761 ECCQADRIHGQSITYTATGRISMTEP---NLQNVAKEFSIQVGSDVVHIS--CRSPFMPTDESRC 1820
            |..| |.:  ..:|:|...|.....|   |||.|.....    ||  |:|  ..:.....::|:|
  Fly  1745 ENKQ-DAV--DYLTWTFLYRRLTQNPNYYNLQGVTHRHL----SD--HLSELVENTLSDLEQSKC 1800

  Fly  1821 LLSAD-------------------FCQLEMRILAHMSQDK--ALLEVMKSS---QDLFI------ 1855
            :...|                   :..:|:..|:..|:.|  .|||::.|:   :|:.:
  Fly  1801 ISVEDDMDTLPLNLGMIAAYYYINYTTIELFSLSLNSKTKVRGLLEIISSAAEYEDVVVRHHEEQ 1865

  Fly  1856 --------------------------------AIAAHWNKIEESEVTQDLRNSTKQV-------- 1880
                                            .:.||.:::   ::..:|:..|:|:
  Fly  1866 VLRTLSQRLPNKLTGPNETAPKFNDPHIKTNLLLQAHLSRL---QLGPELQGDTEQILSKAIRLI 1927

  Fly  1881 --CYGIVYGMGMRSLAESLNCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSKGFVETITGRRR 1943
              |..::...|..|.|.:   :.:.|:|::    ||......|..::.:|  |...|:..|.::
  Fly  1928 QACVDVLSSNGWLSPAVA---AMELAQMVT----QAMWSKDSYLKQLPHF--SPEIVKRCTEKK- 1982

  Fly  1944 YLENINSDVEHLKNQAERQAVN-STIQGSAADIAK--NAILKMEKNIERYREKLALGDNSVDLVM 2005
             :|.: .|:..|:::...:.:. |.:|  .||:|:  |....:|.|.|...:......::|::|:
  Fly  1983 -IETV-FDIMELEDEDRTRLLQLSDLQ--MADVARFCNRYPNIELNYEVVDKDRINSGSTVNVVV 2043

  Fly  2006 HLHDELIFEVPTG----------------------KAKKIAKVLSLTMENCVKLSV 2039
            .|..|   :..||                      |...:..:..||::...|:.:
  Fly  2044 QLERE---DEVTGPVIAPFFPQKREEGWWVVIGDPKTNSLLSIKRLTLQQKAKVKL 2096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125	178/823 (22%)
		DEAD	251..404	CDD:278688	45/163 (28%)
		HELICc	542..616	CDD:197757	35/79 (44%)
		PolA	1489..2055	CDD:223820	137/736 (19%)
		DNA_pol_A_theta	1668..2053	CDD:176475	93/512 (18%)
l(3)72Ab	NP_648818.3	BRR2	466..1241	CDD:224125	201/968 (21%)
		DEAD	482..661	CDD:278688	48/183 (26%)
		HELICc	773..859	CDD:197757	34/91 (37%)
		Sec63	982..1285	CDD:280962	64/411 (16%)
		DEXDc	1320..1506	CDD:214692	56/339 (17%)
		DEAD	1329..1495	CDD:278688	49/319 (15%)
		HELICc	1615..1694	CDD:197757	14/78 (18%)
		Sec63	1811..2127	CDD:280962	49/306 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466308
Domainoid	1	1.000	45	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840