DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-theta and mus301

DIOPT Version :9

Sequence 1:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	273/983 - (27%)
Similarity:	453/983 - (46%)	Gaps:	165/983 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 NQAHKPAEQSVVNVSQVQQHMAVVSNQDSEDQ-SRSSALNDQICTQSS--FEGEDAGADAVLD-- 125
            |.|.||.|.|    :...:|...::::::.|: .:...|||....:..  |.|.|..:|.::.
  Fly    99 NSASKPDEAS----APTDKHQIDLADEENADKLFKKINLNDLSIAEMEDIFHGADDFSDPMVQNT 159

  Fly   126 QPNLDENSFLCPAQDEEASEQLKEDILH--SHSV---------------LAKQEFYQEISQVTQN 173
            |..||..:|..|...|:....||:|.:.  |.||               |..|.....::..||.
  Fly   160 QLFLDAMTFKKPKTPEKLLAPLKDDSMSFISKSVIEGLVQGTQYVTCEELKNQSLLDPVNWETQA 224

  Fly   174 LSSMSPNQLRVSPNSSRIREAMPERPAMPLDLNTLRSISAWNLPMSIQAE-YKKKGVVDMFDWQV 237
            .:....|...:        :..|.:...            :.||..::.. .:.||:..:::||.
  Fly   225 FADFEKNNQDI--------DKFPSKGEF------------YGLPDKVKKMILEHKGINSLYEWQD 269

  Fly   238 ECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKKVLLILPFISVVREKMFYMQDLL 302
            |||:.|.:. :..||:|:.|||.|||||:|||||:.:|.|.:.||.|||::|:|:||:..|....
  Fly   270 ECLNLPAIR-QRKNLIYALPTSGGKTLVAEILMLRELLCRERNVLFILPYVSIVQEKVSAMSPFA 333

  Fly   303 TPAGYRVEGFYGGY-----TPPGGFESLHVAICTIEKANSIVNKLMEQGKLETIGMVVVDEVHLI 362
            ....:.||.:..|.     .|.....||.:|  :|||...:::.|::..:...||:|||||:|||
  Fly   334 IDLDFIVEEYTAGKGKCPPQPRRKRRSLFIA--SIEKGAVLMDSLIDVQRPHEIGLVVVDELHLI 396

  Fly   363 SDKGRGYILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQSWLDAELYITNYRPVALKEMIK 427
            .:||||..||..|.|:::::    ..||::.||||:.|:..:.|:|:|::|...:|||.|||.||
  Fly   397 GEKGRGATLEAFLTKVMFLN----ANIQIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIK 457

  Fly   428 VG---------------------TVIYDHRLKLVRDVAKQKVLLKGLENDSDDVALLCIETLLEG 471
            .|                     :|.|::...:.|             .|.|.:|.|..|...|.
  Fly   458 CGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKR-------------ADPDHLAGLISECAPEH 509

  Fly   472 CSVIVFCPSKDWCENLAVQLATAIHVQIKSETVLGQRLRTNLNPRAIAEVKQQLRDIPTGLD--- 533
            | .:|||||:..|||:|:.|:..:......|....::|                 |:...||
  Fly   510 C-CLVFCPSRKNCENVALLLSRIVPKHKFFEHRRSEKL-----------------DLMDALDKMC 556

  Fly   534 GVMS----KAITYACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPARRVLIRSPL 594
            |::|    |.:.|..|:||:||||:||..||.:::.|.:.|:..||||::||||||:||:||:|.
  Fly   557 GILSPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPY 621

  Fly   595 FGGKQMSSLTYRQMIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQPITSCLDMDGSTHLK 659
            .|.:.::...|:||:|||||.|....||||||....:..:...::.|.:....|.||.:.:..|:
  Fly   622 VGQEFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMDKALSSLDQNEAVGLQ 686

  Fly   660 RALLEVISSGVANTKEDIDFFVNCTLLSAQ-----------------KAFHAKEKPPDEESDANY 707
            ..:|.|:...:|..:.|::..||.||||.|                 :.|..|.....|....:.
  Fly   687 SLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSK 751

  Fly   708 INDALDFLVEYEFVRLQR--NEER----ETAVYVATRLGAACLASSMPPTDGLILFAELQKSRRS 766
            ||.: |.:...:..:..|  .:.|    ::..:..|.:|.|...:.:.......:..||:::::.
  Fly   752 INSS-DIITSQDVSQANRPAGDRRLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQQ 815

  Fly   767 FVLESELHAVYLVTPYSVCY-------QLQDIDWLLYVHMWEKLSSPMKKVGELVGVRDAFLYKA 824
            .:|.:.||.:|||    ||:       :|...|..:...::..|....:.:.:.:|..:|...:.
  Fly   816 LILTNYLHLLYLV----VCFNSNERGDELFPADASILFGVYTSLPLDSQAMFKQLGFTEAHAARL 876

  Fly   825 LRGQTKLDYKQMQIHKRFYIALALEELVNETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFC 889
            .:.|:......:|:: |.|..|.|.:::|..||..|..||...||.||.|...::..|..:...|
  Fly   877 FKTQSVQGPLSLQLN-RLYKVLILADILNLLPIPSVASKYNVERGTLQHLISQSTAAASAIVRLC 940

  Fly   890 NSLQ--WSTLALIVSQFKDRLFFGIHR----DLIDLMRIPDLSQKRARALFDAGITSLVELAGAD 948
            ..|:  |....|.     :|:...:.|    :|..||.:|.:...|||.|:.||..::.::|...
  Fly   941 EELEEFWCYKPLF-----ERILHKMDRCGTFELEPLMELPAVKINRARQLYAAGFQTIGDIARVR 1000

  Fly   949 PVELEKVL 956
            |..|.:.|
  Fly  1001 PSHLVQSL 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125	240/818 (29%)
		DEAD	251..404	CDD:278688	64/157 (41%)
		HELICc	542..616	CDD:197757	38/73 (52%)
		PolA	1489..2055	CDD:223820
		DNA_pol_A_theta	1668..2053	CDD:176475
mus301	NP_648178.1	BRR2	247..998	CDD:224125	236/799 (30%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	78/208 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466311
Domainoid	1	1.000	45	1.000	Domainoid score	I721
eggNOG	1	0.900	-	-		E1_COG0749
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103838at33208
OrthoFinder	1	1.000	-	-		FOG0001214
OrthoInspector	1	1.000	-	-		otm51465
orthoMCL	1	0.900	-	-		OOG6_101025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.650