DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-theta and Helq

DIOPT Version :9

Sequence 1:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_001014156.2	Gene:	Helq / 360912	RGDID:	1560216	Length:	1065	Species:	Rattus norvegicus

Alignment Length:	1075	Identity:	330/1075 - (30%)
Similarity:	523/1075 - (48%)	Gaps:	170/1075 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FSQSFNFGNSTLMALEKGMQADDKENAQPGNGNIQVQSAGNE-VNSEIQEINSEFFRDEFSYEVN 66
            |....:|..::.:|     |.||.|...     ||:...|:. .:|..:::.||...:..|.
  Rat    69 FGDYNSFSENSFLA-----QVDDLEQKY-----IQLPDCGSRGTDSGTKDLCSEGLGNSLSV--- 120

  Fly    67 QAHKPAEQSVVNVSQVQQHMAVVSNQDSEDQSRSSALNDQICTQSSFE---GEDAGADAVLDQPN 128
                ||                |...|||.:       :.|..|...:   ..:.|.|...|.|:
  Rat   121 ----PA----------------VDFTDSETR-------EYIKKQGDLDVPVEPEVGGDLSFDMPS 158

  Fly   129 LDENSFLCPAQDEEASEQL-------------KEDILHSH----------------SVLAKQEFY 164
               :..|.....:.:|:.|             .|::.|||                |..:::...
  Rat   159 ---SQILYFESMQNSSKDLGDQSTKGRDGKSSNEELHHSHREQPQPKSDFSDVGGSSEASRRRSI 220

  Fly   165 QEI--SQVTQNLSSMSPNQLRVSPNSSRIREAM------PERPAMPLDLNTLRSISAWNLPMSIQ 221
            ::.  |.:|.|..:.:|    ..|.|.::||.:      ..|.|:....:.|...  ::||..::
  Rat   221 KDCLKSAMTGNARAQTP----AFPRSKQLRETLLSEEISVARKAIESPSDDLGPF--YSLPSKVR 279

  Fly   222 AEYKK-KGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKKVLLIL 285
            ..|.: ||:..::|||..||:...:. |..||:||.|||.|||||:|||||:.:|.|.|.|||||
  Rat   280 DLYAQLKGIKRLYDWQHTCLTLSSVQ-ERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLLIL 343

  Fly   286 PFISVVREKMFYMQDLLTPAGYRVEGFYG--GYTPP---GGFESLHVAICTIEKANSIVNKLMEQ 345
            |::::|:||:..:.......|:.||.:.|  |..||   ...:||::|  ||||.:|:||.|:|.
  Rat   344 PYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRFPPIKRREKKSLYIA--TIEKGHSLVNALIET 406

  Fly   346 GKLETIGMVVVDEVHLISDKGRGYILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQSWLDA 410
            |::.|:|:|||||:|:|.:..||..||:.|||:||.|:..    |:|.|||||.||:.||::|.|
  Rat   407 GRMGTLGLVVVDELHMIGEGSRGATLEMTLAKVLYTSKTT----QIIGMSATLNNVEDLQAFLKA 467

  Fly   411 ELYITNYRPVALKEMIKVGTVIYDHRLKLVRDVAKQKVL-------LKGLENDSDDVALLCIETL 468
            |.|.:.:|||.|||.:||...||:...:.|..:...::|       ||.:  |.|.:..|..| :
  Rat   468 EYYTSQFRPVELKEFLKVNDTIYEVDSRAVDGMTFSRLLNYKYSDALKKV--DPDRLVALVTE-V 529

  Fly   469 LEGCSVIVFCPSKDWCENLAVQLATAIHVQIKSETVLGQRLRTNLNPR--AIAEVKQQLRDIPTG 531
            :...|.:||||||..|||:|..|...:.             |..||.|  ...|:.:.||::..|
  Rat   530 IPNYSCLVFCPSKKNCENVAEMLCKFLS-------------RDYLNHREEEKGELIKSLRNVGHG 581

  Fly   532 -LDGVMSKAITYACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPARRVLIRSPLF 595
             :..|:.:.|.:..|:||:|||::||.::|.::..|.|.:...||||::|||||||||::|:|..
  Rat   582 KVCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYV 646

  Fly   596 GGKQMSSLTYRQMIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQPITSCLDMDGSTHLKR 660
            ....:....|:||||||||.|.||.|||||:..|.:.:....|:...|:...|.|..:.:..::.
  Rat   647 ANTFLKRNQYKQMIGRAGRAGIDTAGESILLLQEKDKQQVLGLINGPLEDCHSHLVEEFTKGIQS 711

  Fly   661 ALLEVISSGVANTKEDIDFFVNCTLLSAQKAFHAKEKPPDEESDANYINDALDFLVEYEFVRLQR 725
            ..|.:|...:|.:..||..|:|.||...|:....:||...|.:..     ||:.|.|...  ||:
  Rat   712 LFLSLIGLKIAESLGDIYQFMNGTLFGVQQKTLLREKSLWEVTVG-----ALEHLTEKGL--LQK 769

  Fly   726 NE----ERETAVYVATRLGAACLASSMPPTDGLILFAELQKSRRSFVLESELHAVYLVTPYSVCY 786
            :.    |.....:..|:||.|....::..|....|:.:|:|.....||||.||.|||.|||.:..
  Rat   770 DSHGSPEESRCHFRITKLGQASFKGAIDLTYCDTLYRDLKKGLEGLVLESLLHLVYLTTPYDLAA 834

  Fly   787 QLQDIDWLLYVHMWEKLSSPMKKVGELVGVRDAFLYKALRGQT---KLDYKQMQIHKRFYIALAL 848
            | .:.||::|...:.:||...:.|..|:|:.::|:.:...||.   |:|...:   .|.|::..|
  Rat   835 Q-SEPDWMVYFRQFSQLSPAEQSVATLLGISESFIGRKASGQAIRKKVDKNAV---NRLYLSFVL 895

  Fly   849 EELVNETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFCNSLQ--WSTLALIVSQFKDRLFFG 911
            ..|:.||.:..|..::...||.:|:|...|::|:..|..||..|:  |...||: ::...:|.:.
  Rat   896 YSLLKETNVWSVSERFNMPRGYIQNLLMGAASFSSCVLHFCEELEEFWVYKALL-TELTKKLTYC 959

  Fly   912 IHRDLIDLMRIPDLSQKRARALFDAGITSLVELAGADPVELEKVLYNSISFDSAKQHDHENADEA 976
            :..:||.||.:..:.:.||:.|:.||..|:|.||.|:|..|.|.:            ||.:..:|
  Rat   960 VKAELIPLMEVTGVLEGRAKQLYSAGYRSVVHLANANPEVLVKTI------------DHLSRRQA 1012

  Fly   977 AKRNVVRNFYITGKAGMTVSEAAKLLIGEARQFVQ 1011
            .:        |...|.|.:.|.|:.|..||.:.::
  Rat  1013 KQ--------IVSSAKMLLHEKAEALQEEAEELLR 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125	277/793 (35%)
		DEAD	251..404	CDD:278688	77/157 (49%)
		HELICc	542..616	CDD:197757	35/73 (48%)
		PolA	1489..2055	CDD:223820
		DNA_pol_A_theta	1668..2053	CDD:176475
Helq	NP_001014156.2	PRK02362	273..1020	CDD:235032	278/801 (35%)
		DEAD	300..461	CDD:278688	78/167 (47%)
		HELICc	589..667	CDD:197757	36/77 (47%)
		HHH_5	967..1020	CDD:291205	19/72 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103838at33208
OrthoFinder	1	1.000	-	-		FOG0001214
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720