DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-theta and POLN

DIOPT Version :9

Sequence 1:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_861524.2	Gene:	POLN / 353497	HGNCID:	18870	Length:	900	Species:	Homo sapiens

Alignment Length:	896	Identity:	230/896 - (25%)
Similarity:	387/896 - (43%)	Gaps:	161/896 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1237 WTQSENPNNEMNNS------QLPRRNPRNQSPVPNANRTASRKVSNAEEDLFMADDSFMLNTGLA 1295
            |.:|......:|.|      ||..|  :.|||.....::...:.|.....|.....|..|...|:
Human    39 WGKSTETMEVINKSSVKYSVQLEDR--KTQSPEKKDLKSLRSQTSRGSAKLSPQSFSVRLTDQLS 101

  Fly  1296 AALTAAESKIASCTEADVIPSSQPKEPEVIGALTPHASRLKRSDQLRSQRIQSPSPTPQREIEID 1360
            |  ...:..|:|.|.:..:          |......||.|::....|...:.. :...:.:..|:
Human   102 A--DQKQKSISSLTLSSCL----------IPQYNQEASVLQKKGHKRKHFLME-NINNENKGSIN 153

  Fly  1361 LESKNES-NGVSSMEISDMSMENPLMKNPLHLNA-------SHIMSCSKVDETASSFSSIDIIDV 1417
            |:.|:.: |.:|......|::|........:||:       .|......:|:.|.|    .:|::
Human   154 LKRKHITYNNLSEKTSKQMALEEDTDDAEGYLNSGNSGALKKHFCDIRHLDDWAKS----QLIEM 214

  Fly  1418 CGHRNAFQAAIIEINNATRLGFS-------------VGLQAQAGKQKPLIGSNLLINQVAAAENR 1469
            .....|....::..:.:|:||..             |..||:.|...|
Human   215 LKQAAALVITVMYTDGSTQLGADQTPVSSVRGIVVLVKRQAEGGHGCP----------------- 262

  Fly  1470 EAAARERVL--FQVDDTNFISGVSFCLADNVAY--YWNMQIDERAAYQGVPTPLKVQEL---CNL 1527
            :|.|...||  |..||.        |:...:.:  .|:   .|:.|:|.....:..|.:   |.:
Human   263 DAPACGPVLEGFVSDDP--------CIYIQIEHSAIWD---QEQEAHQQFARNVLFQTMKCKCPV 316

  Fly  1528 MA--RKDLTLVM-----HDGKEQLKMLRKAIPQLKRISAKLE-DAKVANWLLQP-DKTVNFLNMC 1583
            :.  .||...::     :||            ..|.::..:. |.::|.||:.| |.|.:|.::.
Human   317 ICFNAKDFVRIVLQFFGNDG------------SWKHVADFIGLDPRIAAWLIDPSDATPSFEDLV 369

  Fly  1584 QTFAPE-CTGLANLCGSGRGYSSYGLDTSSAILPRIRTAIESCVTLHILQGQTENL-SRIGNGDL 1646
            :.:..: .|...|        |:||..:.:.:...:|   |:..||:.|   |.:| |::.:..|
Human   370 EKYCEKSITVKVN--------STYGNSSRNIVNQNVR---ENLKTLYRL---TMDLCSKLKDYGL 420

  Fly  1647 LKFFHDIEMPIQLTLCQMELVGFPAQKQRLQQLYQRMVAVMKKVETKIYEQHGSRFNLGSSQAVA 1711
            .:.|..:|:|:...|..||.......|:.:::....:.|.:|::|.:.:...|.||.:.|:..:.
Human   421 WQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLR 485

  Fly  1712 KV----LGLH----RKAKGRV------TTSRQVLEKLNS--PISHLILGYRKLSGLLAKSIQPLM 1760
            ::    |.||    |.:..|.      :||..||..|..  |:..:||.||::..:.:..:..|:
Human   486 EILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLL 550

  Fly  1761 ECCQADRIHGQ-SITYTATGRISMTEPNLQNVAKEFSIQV-------GSD--VVHISCRSPFMPT 1815
            .|.:...|... :.|.|.|||:|...||:|.::|. .||:       |.:  ::.||.|:.|: :
Human   551 ACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKH-PIQITTPKNFKGKEDKILTISPRAMFV-S 613

  Fly  1816 DESRCLLSADFCQLEMRILAHMSQDKALLEVMKSSQ--DLFIAIAAHWNKIEESEVTQDLRNSTK 1878
            .:....|:|||.|:|:|||.|:|.|..||::.:.|:  |:|..:.:.|..:...:||...|..||
Human   614 SKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTK 678

  Fly  1879 QVCYGIVYGMGMRSLAESLNCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSKGFVETITGRRR 1943
            :|.|.:|||.|...||..|....|||....:.|.|.||.|:|:....:......|.|.:|.||||
Human   679 KVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRR 743

  Fly  1944 YLENINSDVEHLKNQAERQAVNSTIQGSAADIAKNAILKMEKNIERYREKLALGDNSVDLVMHLH 2008
            .|..|::..:.|:.||||||||..:||||||:.|.|::.:      :....|....:..||..:|
Human   744 PLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHV------FTAVAASHTLTARLVAQIH 802

  Fly  2009 DELIFEVPTGKAKKIAKVLSLTMENC-------VKLSVPLKVKLRIGRSWG 2052
            |||:|||...:..:.|.::..|||:.       ::|.|||||.|..|||||
Human   803 DELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWG 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125
		DEAD	251..404	CDD:278688
		HELICc	542..616	CDD:197757
		PolA	1489..2055	CDD:223820	176/615 (29%)
		DNA_pol_A_theta	1668..2053	CDD:176475	136/420 (32%)
POLN	NP_861524.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..90		7/31 (23%)
		DnaQ_like_exo	273..436	CDD:299142	40/199 (20%)
		DNA_pol_A_theta	443..855	CDD:176475	136/419 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	863..900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10133
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910