Protein Alignment PolQ and PolG1

DIOPT Version :10

• Sequence 1: NP_524333.1
• Gene: PolQ / 41571
• FlyBaseID: FBgn0002905
• Length: 2059
• Species: Drosophila melanogaster
• Sequence 2: NP_476821.1
• Gene: PolG1 / 34792
• FlyBaseID: FBgn0004406
• Length: 1145
• Species: Drosophila melanogaster
• Alignment Length: 1200
• Identity: 217/1200 - (18%)
• Similarity: 365/1200 - (30%)
• Gaps: 461/1200 - (38%)

  Fly  1147 IQKQGSQIEKMKINPATV-----VCSPQLANE-EKPSTSQSA----RRKLVNEGMAERR-RVALM 1200
            |:|..|::.:.....::|     |..||..|: :||...::.    ...||...|..|. ...|.
  Fly     6 IRKYASKVSREHYASSSVKIFRRVKPPQKVNKPKKPENVENGPTEYAENLVKVQMISRNLHAQLF 70

  Fly  1201 KIQQRTQKENQ------SKDQPIQASRSNQLSSPVN----RTPANRWTQSE-----------NPN 1244
            ....|:..|.|      .||:..:.....:.|:||:    :.||.|....|           .|.
  Fly    71 PQAPRSISEQQVASAKVYKDELRRHGVDIESSAPVSDVQLKLPALRGANIEEHFHNIAKEQVQPY 135

  Fly  1245 NEM-----NNSQLPRR-------------NPRNQSPVPNANRTASRKVSNAEEDLFMADDSFMLN 1291
            .|:     ...|||:|             :|.:.:..|         |.:..|...:.|....::
  Fly   136 EELLLPLVQCEQLPKRPKRWAFHTGWTAYDPEDGTATP---------VDHPLEKGLVFDVEVCVS 191

  Fly  1292 TGLAAALTAAES-----------------KIASCTEADVIPSSQPKEPEVIGALTPHASRLKRSD 1339
            .|.|..|..|.|                 .:......||...|:          .||.:    :|
  Fly   192 EGQAPVLATAVSTKRWYSWVSSKLTKHRLSVEKLEPLDVDTDSE----------RPHYT----TD 242

  Fly  1340 QLRSQRIQSPSPTPQREIEID---LESKNESNGVSSMEISDMSMENPLMKNPLHLNASHIMSC-- 1399
            :|.......|.......:..|   |:.:..:....:..:..||         ||:..|.:.|.
  Fly   243 ELIPLGTTGPGLVVGHNVSYDRARLKEQYLTEDTGTRFVDTMS---------LHMCVSGVTSYQR 298

  Fly  1400 ----SKVDETA--------SSFSSIDIIDV----CG-------HRNAFQAAIIEINNATRLGFSV 1441
                ||.:..|        ||.:|  :::|    ||       .||.|....:|
  Fly   299 AMLKSKKEPAAEDLGWLEQSSLNS--LVEVHRLYCGGDTLSKEPRNIFVEGTLE----------- 350

  Fly  1442 GLQAQAGKQKPLIGSNLLINQVAAAENREAAAR-ERVLFQVDDTNFISGVSFC--LADNVAYY-- 1501
              |.:...|.       |.|.  .|.:.||..| .|||:.:....|....|..  |....||.
  Fly   351 --QVRQSFQS-------LTNY--CASDVEATHRILRVLYPLYAERFPHPASLAGMLEMGSAYLPV 404

  Fly  1502 ---WNMQIDE-RAAYQGVPTPLK------VQELCNLMA----RKDLTLVMHD-GKEQLKM----L 1547
               |...|.| :..|:.:....|      .:|.|:|:.    |::|.|...| ..::||:    .
  Fly   405 NSNWERYIREAQLTYEDLSIEAKYHLGRRAEEACSLLLDDQYRQNLWLWDEDWSVQELKLKQPPK 469

  Fly  1548 RKAIPQL-----------KRISAKLE------------------------------DAKVANWLL 1571
            ||.:|.:           :|:.||.:                              .||.|:.:|
  Fly   470 RKPLPTVELKDSGNTPEERRLQAKFQHLYDQQALLPARRPLLPGYPLWYRKLCRKPPAKRADEIL 534

  Fly  1572 QPDKT-----VNFLNMCQTFAPECTGLANLCGSG--------RGY--------SSYGLDTSSAIL 1615
            :.|:.     .:.::.....||:   |.:||..|        :|:        .|.|:|.    |
  Fly   535 EDDEEPWSPGASEISTGMQIAPK---LLSLCWEGYPLHYEREQGWGFLVPFRSDSEGVDR----L 592

  Fly  1616 P--------------RIRTA-IESCVTLHILQGQTENLSRIGNGDLLKFFHDIEMPIQLTLCQME 1665
            |              |:..: .||.:...:|.||.|  ..:|..:..|           .|.|
  Fly   593 PMEQLLAHCPVPEFARLSASKAESDMAFDMLPGQVE--QHLGKREHYK-----------KLSQ-- 642

  Fly  1666 LVGFPAQKQRLQQLYQRMVAVMKKV------ETKIYEQHGSRFNLG------------------- 1705
                  ::|||:..||.......||      ..|:..::|..|.:|
  Fly   643 ------KQQRLETQYQGSGVWCNKVLDDCCFFLKLPHKNGPSFRVGNPLSKDFLNKFAENVLSSG 701

  Fly  1706 --SSQAVAKVLGLHRKAKGRVTTSRQVLEKLNSPISHLILGYRKLSGLLAKSIQPLMECCQADRI 1768
              |.||.|:|:.:.|                       ::.|.:.:               .|||
  Fly   702 DPSCQAAARVIDIAR-----------------------MMSYWRNN---------------RDRI 728

  Fly  1769 HGQSITYTATGRISMTEPNLQNVAKEFSIQVGSDVVH-------ISC----RSPFMPTDESRCLL 1822
            .||.:.:.          :.|.:..||:.:....:.:       ::|    |....||..:....
  Fly   729 MGQMVVWL----------DSQQLPNEFTGEKCQPIAYGAICPQVVACGTLTRRAMEPTWMTASNS 783

  Fly  1823 SADFCQLEMRILAHMSQDKALLEVMKSSQDLFI--------AIAAH------WNKIEESEVT-QD 1872
            ..|....|:|.:........|:.....||:|:|        |...|      |..:..|:.. .|
  Fly   784 RPDRLGSELRSMVQAPPGYRLVGADVDSQELWIASVLGDAYACGEHGATPLGWMTLSGSKSNGSD 848

  Fly  1873 L-----------RNSTKQVCYGIVYGMG-------MRSLAESLNCSEQEAR-------------- 1905
            :           |:..|.:.|..:||.|       :|....:.:.||.:|:
  Fly   849 MHSITAKAVGISRDHAKVINYARIYGAGQLFAETLLRQFNPTFSASEAKAKAMKMFSITKGKRVY 913

  Fly  1906 MISDQFH-----QAYKGIRDYTTRVVNFARSKGFVE----------TITGRRRYLENINS----- 1950
            .:.::||     :||.   .|....:...|::...|          |.:.....||.|.:
  Fly   914 RLREEFHDELEDRAYS---SYEASRLAIQRNRTLAEVFHRPNWQGGTESAMFNRLEEIATGSQPR 975

  Fly  1951 ------------DVEHLKNQAER---QAVNSTIQGSAADIAKNAILKMEKNIERYREKLALGDNS 2000
                        :.:....|.:|   ..:|..:|..|.|.....::.|         :..:|.:
  Fly   976 TPFLGGRLSRALEADTGPEQEQRFLPTRINWVVQSGAVDFLHLMLVSM---------RWLMGSH- 1030

  Fly  2001 VDLVMHLHDELIFEVPTGKAKKIAKVLSLT 2030
            |...:..||||.:.|....:.|.|..:.:|
  Fly  1031 VRFCLSFHDELRYLVKEELSPKAALAMHIT 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolQ	NP_524333.1	BRR2	216..779	CDD:440817
		DNA_pol_A_theta	1668..2053	CDD:176475	80/482 (17%)
PolG1	NP_476821.1	DNApol_Exo	107..381	CDD:465664	60/329 (18%)
		DNA_pol_A	398..>440	CDD:470638	9/41 (22%)
		DNA_pol_gammaA	705..1107	CDD:176478	68/416 (16%)