DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-theta and polq-1

DIOPT Version :9

Sequence 1:NP_524333.1 Gene:DNApol-theta / 41571 FlyBaseID:FBgn0002905 Length:2059 Species:Drosophila melanogaster
Sequence 2:NP_001367994.1 Gene:polq-1 / 175810 WormBaseID:WBGene00020964 Length:1603 Species:Caenorhabditis elegans


Alignment Length:1935 Identity:514/1935 - (26%)
Similarity:864/1935 - (44%) Gaps:454/1935 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 YKKKGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKKVLLILPFI 288
            |.::.:..:||||::.|::.| .||..:|::||||||||::|:|:|..| |...|:|||.:||:|
 Worm    20 YAEQNIKALFDWQIDVLNEAR-QFEDQHLIFSAPTSAGKSIVAELLSWK-VASTGRKVLFVLPYI 82

  Fly   289 SVVREKMFYMQDLLTPAGYRVEGFYGGY-TPPGGFESLHVAICTIEKANSIVNKLMEQGKLETIG 352
            ||.|||:..:|.........|.||.|.. :.|..:..   |:||||||.|:.|:.:.:...|.||
 Worm    83 SVAREKLHQIQRCWRRDDISVCGFIGPQASNPNEWLG---AVCTIEKAASLTNRALSEDWFEEIG 144

  Fly   353 MVVVDEVHLISDKGRGYILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQSWLD-AELYITN 416
            |:||||:|::.|..||..:|.:|:|:|..::....::::|.||||:..:..:..||| |:::...
 Worm   145 MIVVDEMHMVFDSSRGAHIEHMLSKVLLWNQSALEKVRIIGMSATIPELYRIGKWLDGAKVFEAR 209

  Fly   417 YRPVALKEMIKVGTVIYDHRLKLVRDVAKQKVLLKGLENDSDDVALLCIETLLEGCSVIVFCPSK 481
            :||:.|:..|.:|:.:        |.....|||   .|...|.:.||..|:.......:|...||
 Worm   210 FRPIVLQNHIVIGSEL--------RKSGDNKVL---REFSEDPLILLTEESFRRNSQTLVMISSK 263

  Fly   482 DWCENLAVQLATAIHVQIKSETVLGQRLRTNLNPRAIAEVKQQLRDIPTGLD-------GVMSKA 539
            ...|..|:.:|:..|...|:::.|.:.|:...|         .|..|..||:       .||| .
 Worm   264 LDAEKTALNIASRFHEINKTDSSLLEILKERAN---------GLLFIKHGLERNGCKDRNVMS-T 318

  Fly   540 ITYACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPARRVLIRSPLFGGKQMSSLT 604
            :.:..|:||||||.|||:.||..|:...:.:|||||||:|||||||.||||::...|...::||.
 Worm   319 LAWGVAYHHAGLTMEERECIELGFREKNIVILVATSTLASGVNLPAERVLIKAQPRGPSALTSLN 383

  Fly   605 YRQMIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQ-PI-----TSCLDMDGSTHLKRALL 663
            ||||:|||||.|..|.||:.|:..:.:    ||.|:..:: ||     |...|.: .|:|.|.:|
 Worm   384 YRQMVGRAGRTGHATRGETYLLIKKCD----RDAVLKIIETPIDQGVLTRKRDAE-RTNLSRFIL 443

  Fly   664 EVISSGVANTKEDIDFFVNCTLLSAQKAFHAKEKPPDEESDANYINDALDFLVEYEFVRLQRNEE 728
            |.|.:|:..|:..|.......|.:::..         :.||.     |::.|:...|:....|::
 Worm   444 EGICTGLTTTRSQIHDLCKLLLFNSENL---------QLSDI-----AIEMLLRNSFISQDENDD 494

  Fly   729 RETAVYVATRLGAACLASSMPPTDGLILFAELQKSRRSFVLESELHAVYLVTPYSVCYQLQDIDW 793
            :.:    .|:||.|.:|||:||...|.:|.:|..:.|:..|::|||.:|||||.:|.. .|:.||
 Worm   495 QLS----PTQLGRAAIASSLPPEASLAIFEDLNSASRAIALDTELHMLYLVTPINVSV-WQECDW 554

  Fly   794 LLYVHMWEKLSSPMKKVGELVGVRDAFLYKALRGQTKLDYKQMQIHKRFYIALALEELVNETPIN 858
            .....::.||.|..|::.:||||.:.|:...|:|  :.:.|.:|||.||:.||||.:|::|..|.
 Worm   555 HHLFSIFSKLPSDHKRIAKLVGVSEKFILDQLQG--RRNDKLLQIHIRFFSALALFDLISEMSIY 617

  Fly   859 VVVHKYKCHRGMLQSLQQMASTFAGIVTAFCNSLQWSTLALIVSQFKDRLFFGIHRDLIDLMRIP 923
            .|.|||:..||.||:||..::|:|.::.|||..|.|:.|..::..|..||.||:..:|.:|:.|.
 Worm   618 EVSHKYRIPRGCLQTLQSQSATYAAMIVAFCLRLGWTYLKALLDGFATRLLFGVRSELSELVAIE 682

  Fly   924 DLSQKRARALFDAGITSLVELAGADPVELEKVLYNSISFDSAKQHDHENADEAAKRNVVRNFYIT 988
            .:..:|||.|.:.|:|.|..|:..|..:|...|..::.:.|:..:|....            ::.
 Worm   683 GIDGQRARILHERGVTCLSHLSACDSSKLAHFLTLAVPYSSSNSNDGLGE------------WLF 735

  Fly   989 GKAGMTVSEAAKLLIGEARQFV---QHEIGLGT--IKWTQTQAGVEIASRAIHDGGEVDLHMSLE 1048
            |:..|.|..||:.|...||:.:   ..|:|:..  .|:.:.:..::.:.    |.|..|....:|
 Worm   736 GEPRMRVDVAARTLKERARKVLIRRVQELGISVELPKFEENEENIQESC----DSGLPDSCEGME 796

  Fly  1049 EEQPPVKRKLSIEENGTANSQKNPRLETVVDTQRGYKVDKNIANQSKMNPNLKEIDAQNKARRNS 1113
            :|         :||.                        :||....:|..::.|:...:      
 Worm   797 DE---------LEEK------------------------ENIVKMEEMTKSVTEMSLTD------ 822

  Fly  1114 TAHMDNLNPISNDPCQNNVNVKTAQPIISNLNDIQKQGSQIEKMKINPATVVCSPQLANEEKPST 1178
                            |.::.|:.       :|:.|     :::|:....|....::..:|:   
 Worm   823 ----------------NTISFKSE-------DDLFK-----KEIKVEEDEVFIKKEIDEDEE--- 856

  Fly  1179 SQSARRKLVNEGMAERRRVALMKIQQRTQKENQSKDQPIQASRSNQLSSPVNRTPA--NRWTQSE 1241
                  ::|.|.:.|....:|:|::..|.:        :...|.:|..||:.|:.:  |.....:
 Worm   857 ------EIVEETVIECLETSLLKLKASTDE--------VFLRRLSQTFSPIGRSRSILNNSLLED 907

  Fly  1242 NPNNEMNNSQLPRRN---PRNQSPVPNANRTASRKVSNAEEDLFMADDSFMLNTGLAAALTAAES 1303
            :.:..:..|.:|..|   |:.:||.|....:..|.:..:                          
 Worm   908 SFDRPVPRSSIPILNFITPKRESPTPYFEDSFDRPIPGS-------------------------- 946

  Fly  1304 KIASCTEADVIPSSQPKEPEVIGALTPHASRLKRSDQLRSQRIQSPS------------PTPQRE 1356
                      :|.|..:...|:       :.:...|..|.:.|.|.:            ||...:
 Worm   947 ----------LPISSSRRKSVL-------TNIANLDSSRRESINSNASDNNSFDVFVTPPTKSAK 994

  Fly  1357 IE---IDLESKNESNGVSSMEISDMSMENPLMKNP-LHLN--------------------ASHIM 1397
            .|   |.::.....|.:.|...|     :|::|:| |.:|                    ::...
 Worm   995 EEKRRIAVKHPRVGNIIYSPLTS-----SPVIKHPKLEINHFYLKDVCHDHNAWNLWTKSSTSTS 1054

  Fly  1398 SCS-KVDE--------TASSFSSIDIIDVCG--------HRNAFQAAIIEINNATRLGFSVGLQA 1445
            ||| :|.:        |.:..:.|.:::..|        :..:|...||.:|  |||.|...|  
 Worm  1055 SCSIRVSDDYTGIAIRTDAGNTFIPLLETFGGEPSPASKYFESFSKCIIPLN--TRLEFLKTL-- 1115

  Fly  1446 QAGKQKPLIGSNLLINQVAAAENREAAARERVLFQVDDTNFI---SGVSFCLADNVAYYWNMQID 1507
                                     |...|..:..::|...|   .|:..         :.:::.
 Worm  1116 -------------------------AVTVEMYISSMEDAFLIFEKFGIKI---------FRLKVV 1146

  Fly  1508 ERAAYQGVPTPLKVQELCNLMARKDLTLVMHDGKEQLKMLRKAI--PQL-KRISAKLEDAKVANW 1569
            ..|||......::.:|..|.:              .:.|.|.:|  |:: |..|:.|..|.|..:
 Worm  1147 RIAAYLNNVIDVEQEENSNFL--------------PILMDRYSILDPEIRKTCSSSLHKAAVEVY 1197

  Fly  1570 LLQPDKTVNFLNMCQTFAPECTGLANLCGSGRGYSSYGLDTSSAILPRIRTAIESCVTLHILQGQ 1634
            .|:|    .|..||      |:|.:                       ::..:|||.|       
 Worm  1198 SLKP----IFEKMC------CSGAS-----------------------LQLEMESCQT------- 1222

  Fly  1635 TENLSRIGNGDLLKFFHDIEMPIQLTLCQMELVGFPAQKQRLQQLYQRMVAVMKKVETKIYEQHG 1699
                       :|..|:. .:.....||...:  :..:||            ::.:|..|:....
 Worm  1223 -----------VLNIFYS-GIVFDQALCNSFI--YKIRKQ------------IENLEENIWRLAY 1261

  Fly  1700 SRFNLGSSQAVAKV----LGL-HRKAKG------RVTTSRQVLEKLNS--PISHLILGYRKLSGL 1751
            .:||:.||..||.|    ||| :.:..|      .:.|::.:||::|:  ||...||.||::...
 Worm  1262 GKFNIHSSNEVANVLFYRLGLIYPETSGCKPKLRHLPTNKLILEQMNTQHPIVGKILEYRQIQHT 1326

  Fly  1752 LAKSIQPLMECCQADRIHGQSITYTATGRISMTEPNLQNVAKEFSIQVGSDVVHISCRSPFMPTD 1816
            |.:.:.||.:.  ..|||......|:||||..:.||||||.|    ::.||  .:|.|..|:...
 Worm  1327 LTQCLMPLAKF--IGRIHCWFEMCTSTGRILTSVPNLQNVPK----RISSD--GMSARQLFIANS 1383

  Fly  1817 ESRCLLSADFCQLEMRILAHMSQDKALLEVMKSSQDLFIAIAAHWNKIEESEVTQDLRNSTKQVC 1881
            |: .|:.||:.|||:|:|||:|.|..|:.::.|.:|||..::..||         ..|::.||:|
 Worm  1384 EN-LLIGADYKQLELRVLAHLSNDSNLVNLITSDRDLFEELSIQWN---------FPRDAVKQLC 1438

  Fly  1882 YGIVYGMGMRSLAESLNCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSKGFVETITGRRRYLE 1946
            ||::||||.:||:|....|.::|..:...|...:.|:|.|..........:..:.||.|||..::
 Worm  1439 YGLIYGMGAKSLSELTRMSIEDAEKMLKAFFAMFPGVRSYINETKEKVCKEEPISTIIGRRTIIK 1503

  Fly  1947 NINSDVEHLKNQAERQAVNSTIQGSAADIAKNAILKMEKNIERYREKLALGDNSVDLVMHLHDEL 2011
              .|.:...:.:.||.|||.||||||::|.|.||:.:|..|:.:         ...:|:.:|||:
 Worm  1504 --ASGIGEERARIERVAVNYTIQGSASEIFKTAIVDIESKIKEF---------GAQIVLTIHDEV 1557

  Fly  2012 IFEVPTGKAKKIAKVLSLTMENCVK------LSVPLKVKLRIGRSWGEFK 2055
            :.|.|    :......|.::|||::      |.||::|.::.||||.:.|
 Worm  1558 LVECP----EIHVAAASESIENCMQNALSHLLRVPMRVSMKTGRSWADLK 1603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-thetaNP_524333.1 BRR2 209..978 CDD:224125 267/768 (35%)
DEAD 251..404 CDD:278688 62/153 (41%)
HELICc 542..616 CDD:197757 43/73 (59%)
PolA 1489..2055 CDD:223820 158/587 (27%)
DNA_pol_A_theta 1668..2053 CDD:176475 128/403 (32%)
polq-1NP_001367994.1 BRR2 12..696 CDD:224125 258/727 (35%)
DNA_pol_A_theta 1230..1602 CDD:176475 130/418 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160159302
Domainoid 1 1.000 175 1.000 Domainoid score I2188
eggNOG 1 0.900 - - E1_COG0749
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 519 1.000 Inparanoid score I688
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG60134
OrthoDB 1 1.010 - - D103838at33208
OrthoFinder 1 1.000 - - FOG0001214
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101025
Panther 1 1.100 - - LDO PTHR10133
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2964
SonicParanoid 1 1.000 - - X4573
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1312.840

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