DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNApol-theta and helq-1

DIOPT Version :9

Sequence 1:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_001022911.1	Gene:	helq-1 / 175210	WormBaseID:	WBGene00021905	Length:	923	Species:	Caenorhabditis elegans

Alignment Length:	839	Identity:	262/839 - (31%)
Similarity:	423/839 - (50%)	Gaps:	115/839 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 PNQLRVSPNSSRIREAMPERPAMPLDLNTLRSISAWNLPMSIQAEYKKKGVVDMFDWQVECLSKP 243
            |..|.:.|:     :.:|||     |:...|.|               |.:...:|||.||||..
Worm   140 PETLTLDPS-----KCLPER-----DMEMYRKI---------------KKLDKFYDWQQECLSDK 179

  Fly   244 RLL-FEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKKVLLILPFISVVREKMFYMQDLLTPAGY 307
            ||| .|:|  :.|.||.|||||::|:|||:..:.|.:..:|:||::::|:||:..:.......|.
Worm   180 RLLDGENC--ILSLPTGAGKTLIAEVLMLREAIVRKRNAILVLPYVAIVQEKISALAPFEDAFGI 242

  Fly   308 RVEGF---YGGYTPPGGFESLHVAICTIEKANSIVNKLMEQGKLETIGMVVVDEVHLISDKGRGY 369
            .:|.:   .|.:.|....:.:.|.:.||||||.::|.|:.||:|:.:|||||||:|:|.|.|||.
Worm   243 NIEEYASNKGRFPPIKRRKRVSVYVATIEKANMLINSLITQGQLDRVGMVVVDELHMIGDGGRGA 307

  Fly   370 ILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQSWLDAELYITNYRPVALKEMIKVGTVIYD 434
            |||.||||.||  :..|   |::.|||||.|:..|:..|.|.:|.||:|||.|.|.:|:|..:
Worm   308 ILEQLLAKFLY--KGTG---QIVGMSATLPNIDDLKFALRAFVYSTNFRPVELTEFVKIGQTM-- 365

  Fly   435 HRLKLVRDVAKQKVL----LKGLENDSDDVALLCIETLLEGCSVIVFCPSKDWCENLAVQLATAI 495
            |::....|:.....|    ||  ..|.|.:..| :..|:...|.::|||:|..|||:||.:|..:
Worm   366 HQVSENGDLNPAGDLPTNNLK--STDPDGICQL-LAKLIPKNSAVIFCPNKKNCENVAVLIAKTL 427

  Fly   496 HVQIK------SETVLGQRLRTNLNPRAIAEVKQQLRDIPTGLDGVMSKAITYACAFHHAGLTTE 554
            ...|:      |:..|...|..|.:.|               :|.|:.:.|....|:||:|||.:
Worm   428 PAHIRQAKRAESDAFLQSYLSDNDDER---------------MDAVLKQCILSGVAYHHSGLTQD 477

  Fly   555 ERDIIEASFKAGALKVLVATSTLSSGVNLPARRVLIRSPLFGGKQMSSLTYRQMIGRAGRMGKDT 619
            ||..:||:|..|.:.|:.|||||::|||||.|||:|::|:.|.:::....|.||.|||||.|.||
Worm   478 ERKCVEAAFMEGLIYVVCATSTLAAGVNLPVRRVIIKAPMVGRERLGKAQYLQMAGRAGRAGFDT 542

  Fly   620 LGESILICNEINA----RMGRDLVVSELQPITSCLDMDGSTHLKRALLEVISSGVANTKEDIDFF 680
            .|:.|.|   |.|    |..|:::.|::....|.|..:.|  :...:|:.:...:|...|:|...
Worm   543 KGDCITI---IKAGEEERWFREMLKSDIPRCMSSLSSEES--MGSFILDCVVLKLAENIEEIMTA 602

  Fly   681 VNCTLLSAQKAFHAKEKPPDEESDANYINDALDFLVEYEFVRLQRNEE--------------RET 731
            |..:|      |:|:|.|   |:....:..::..|.|:.|:.::..|:              |..
Worm   603 VRYSL------FYAQESP---ENIRKLVESSVKRLEEHYFITIEPLEQDVASEPSAQASSIPRVP 658

  Fly   732 AVYVATRLGAACLASSMPPTDGLILFAELQKS-RRSFVLESELHAVYLVTPYSVCYQLQDIDWLL 795
            .....:.||.|...:...|.:...|.|:|..| .:..:..|..|.::::|||.   |:.:|:|.|
Worm   659 GKISPSDLGNAVFNAGFDPDEATRLHADLVSSLNQGVIFASHFHLLFIITPYE---QVCNINWDL 720

  Fly   796 YVHMWEKLSSPMKKVGELVGVRDAFLYKALRGQTKLDYKQMQIHKRFYIALALEELVNETPINVV 860
            ::.|:..|.|..:|:....|:.:.|:.:|:  .|::|........|.||||.|:::.|..|:..|
Worm   721 FLLMYNALPSSERKLLAECGLEEKFILEAI--ITRVDLTAGTPRMRLYIALMLQKIWNHEPMYTV 783

  Fly   861 VHKYKCHRGMLQSLQQMASTFAGIVTAFCNSL--QWSTLALIVSQFKDRLFFGIHRDLIDLMRIP 923
            ..::...:|.||:..|.:.:.|..:..|...:  .| .|..::.:...||......:|:.||.:.
Worm   784 AERFGVEKGWLQATLQSSISQAASIAKFSEKITTMW-PLRKLLPELVQRLSEAAQPELLPLMTVD 847

  Fly   924 DLSQKRARALFDAGITSLVELAGADPVELEKVL-------YNSISFDSAKQHDHENADE 975
            .:.:.||..||.||..::..:|.|:|::|.:.|       .||| ..||:....:..||
Worm   848 GIKKARAAILFKAGYKTVGMIARANPLKLVQELGTIRMAQANSI-IASARMVLRDQVDE 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125	255/809 (32%)
		DEAD	251..404	CDD:278688	65/155 (42%)
		HELICc	542..616	CDD:197757	37/73 (51%)
		PolA	1489..2055	CDD:223820
		DNA_pol_A_theta	1668..2053	CDD:176475
helq-1	NP_001022911.1	BRR2	134..896	CDD:224125	259/828 (31%)
helq-1	NP_001022911.1	DEXHc_POLQ-like	151..352	CDD:350784	90/227 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103838at33208
OrthoFinder	1	1.000	-	-		FOG0001214
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820