Protein Alignment DNApol-theta and HELQ

DIOPT Version :9

• Sequence 1: NP_524333.1
• Gene: DNApol-theta / 41571
• FlyBaseID: FBgn0002905
• Length: 2059
• Species: Drosophila melanogaster
• Sequence 2: NP_598375.3
• Gene: HELQ / 113510
• HGNCID: 18536
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 1120
• Identity: 337/1120 - (30%)
• Similarity: 540/1120 - (48%)
• Gaps: 179/1120 - (15%)

  Fly     9 FGNSTLMAL--------EKGMQADDKENAQPGNGNIQVQS------------AGNEVNSEI---- 49
            ||..|...|        |:.|.|:::.....|...::||.            .|.:.|.::
Human    26 FGAPTAAELVPGDEGKEEEEMVAENRRRKTAGVLPVEVQPLLLSDSPECLVLGGGDTNPDLLRHM 90

  Fly    50 --------QEINSE--FFRDEFSYEVNQAHKPAEQSVVNVSQVQQHMAVVSNQDSEDQSRSSALN 104
                    |..:||  .|.|..|:..|......:.......|:.:|....::..:|:....|..|
Human    91 PTDRGVGDQPNDSEVDMFGDYDSFTENSFIAQVDDLEQKYMQLPEHKKHATDFATENLCSESIKN 155

  Fly   105 DQICT----------------QSSFEGE--DAGADAVLDQP--------NLDENSFLCPAQDEEA 143
            ....|                ||.:||.  :.|||.:.|.|        ||..:|      ::..
Human   156 KLSITTIGNLTELQTDKHTENQSGYEGVTIEPGADLLYDVPSSQAIYFENLQNSS------NDLG 214

  Fly   144 SEQLKED--ILHSHSVLAKQEFYQEISQVTQNLSSMSPNQLRVSPNSSR-------IREAMP--E 197
            ...:||.  ...||:.:.::..:..|.|..||..|.|  ::|.|.:.:|       ::.||.  .
Human   215 DHSMKERDWKSSSHNTVNEELPHNCIEQPQQNDESSS--KVRTSSDMNRRKSIKDHLKNAMTGNA 277

  Fly   198 RPAMPL--------------DLN----TLRSIS-----AWNLPMSIQAEYKK-KGVVDMFDWQVE 238
            :...|:              ::|    |:.|.|     .::||..::..|.: ||:..:::||..
Human   278 KAQTPIFSRSKQLKDTLLSEEINVAKKTVESSSNDLGPFYSLPSKVRDLYAQFKGIEKLYEWQHT 342

  Fly   239 CLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKKVLLILPFISVVREKMFYMQDLLT 303
            ||:. ..:.|..||:||.|||.|||||:|||||:.:|...|.||:|||::::|:||:..:.....
Human   343 CLTL-NSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEKISGLSSFGI 406

  Fly   304 PAGYRVE---GFYGGYTPPGGFESLHVAICTIEKANSIVNKLMEQGKLETIGMVVVDEVHLISDK 365
            ..|:.||   |..|.:.|....|...:.|.||||.:|:||.|:|.|:::::|:|||||:|:|.:.
Human   407 ELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDSLGLVVVDELHMIGEG 471

  Fly   366 GRGYILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQSWLDAELYITNYRPVALKEMIKVGT 430
            .||..||:.||||||.|:..    |:|.|||||.||:.||.:|.||.|.:.:|||.|||.:|:..
Human   472 SRGATLEMTLAKILYTSKTT----QIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKIND 532

  Fly   431 VIYDHRLKLVRDVAKQKVL-------LKGLENDSDDVALLCIETLLEGCSVIVFCPSKDWCENLA 488
            .||:...|....:...::|       ||.:  |.|.:..|..| ::...|.:||||||..|||:|
Human   533 TIYEVDSKAENGMTFSRLLNYKYSDTLKKM--DPDHLVALVTE-VIPNYSCLVFCPSKKNCENVA 594

  Fly   489 VQLATAIHVQIKSETVLGQRLRTNLNPRAIAEVKQQLRDIPTG-LDGVMSKAITYACAFHHAGLT 552
            ..:.     :..|:..|..:.:..      .||.:.|::|..| |..|:.:.|.:..|:||:|||
Human   595 EMIC-----KFLSKEYLKHKEKEK------CEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLT 648

  Fly   553 TEERDIIEASFKAGALKVLVATSTLSSGVNLPARRVLIRSPLFGGKQMSSLTYRQMIGRAGRMGK 617
            ::||.::|.::..|.|.:...||||::|||||||||::|:|....:.:....|:||||||||.|.
Human   649 SDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRAGRAGI 713

  Fly   618 DTLGESILICNEINARMGRDLVVSELQPITSCLDMDGSTHLKRALLEVISSGVANTKEDIDFFVN 682
            ||:||||||..|.:.:...:|:...|:...|.|..:.:..::...|.:|...:|...:||..|:|
Human   714 DTIGESILILQEKDKQQVLELITKPLENCYSHLVQEFTKGIQTLFLSLIGLKIATNLDDIYHFMN 778

  Fly   683 CTLLSAQKAFHAKEKPPDEESDANYINDALDFLVEYEFVR---LQRNEERETAVYVATRLGAACL 744
            .|....|:....|||     |......::|.:|.|...::   :.::||.....:..|:||.|..
Human   779 GTFFGVQQKVLLKEK-----SLWEITVESLRYLTEKGLLQKDTIYKSEEEVQYNFHITKLGRASF 838

  Fly   745 ASSMPPTDGLILFAELQKSRRSFVLESELHAVYLVTPYSVCYQLQDIDWLLYVHMWEKLSSPMKK 809
            ..::......||:.:|:|.....||||.||.:||.|||.:..|... ||::|...:.:||...:.
Human   839 KGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPYDLVSQCNP-DWMIYFRQFSQLSPAEQN 902

  Fly   810 VGELVGVRDAFLYKALRGQT---KLDYKQMQIHKRFYIALALEELVNETPINVVVHKYKCHRGML 871
            |..::||.::|:.|...||.   |:|   ..:..|.|::..|..|:.||.|..|..|:...||.:
Human   903 VAAILGVSESFIGKKASGQAIGKKVD---KNVVNRLYLSFVLYTLLKETNIWTVSEKFNMPRGYI 964

  Fly   872 QSLQQMASTFAGIVTAFCNSLQ--WSTLALIVSQFKDRLFFGIHRDLIDLMRIPDLSQKRARALF 934
            |:|....::|:..|..||..|:  |...||:|...| :|.:.:..:||.||.:..:.:.||:.|:
Human   965 QNLLTGTASFSSCVLHFCEELEEFWVYRALLVELTK-KLTYCVKAELIPLMEVTGVLEGRAKQLY 1028

  Fly   935 DAGITSLVELAGADPVELEKVLYNSISFDSAKQHDHENADEAAKRNVVRNFYITGKAGMTVSEAA 999
            .||..||:.||.|:|    :||..:|...|.:|         ||:               :..:|
Human  1029 SAGYKSLMHLANANP----EVLVRTIDHLSRRQ---------AKQ---------------IVSSA 1065

  Fly  1000 KLLIGEARQFVQHEI 1014
            |:|:.|..:.:|.|:
Human  1066 KMLLHEKAEALQEEV 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125	274/793 (35%)
		DEAD	251..404	CDD:278688	73/155 (47%)
		HELICc	542..616	CDD:197757	35/73 (48%)
		PolA	1489..2055	CDD:223820
		DNA_pol_A_theta	1668..2053	CDD:176475
HELQ	NP_598375.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..261		12/50 (24%)
		PRK02362	318..1066	CDD:235032	274/804 (34%)
		DEXHc_POLQ-like	319..521	CDD:350784	89/206 (43%)
		DEAH box	463..466		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0749
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103838at33208
OrthoFinder	1	1.000	-	-		FOG0001214
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101025
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720