DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-theta and POLQ

DIOPT Version :9

Sequence 1:NP_524333.1 Gene:DNApol-theta / 41571 FlyBaseID:FBgn0002905 Length:2059 Species:Drosophila melanogaster
Sequence 2:NP_955452.3 Gene:POLQ / 10721 HGNCID:9186 Length:2590 Species:Homo sapiens


Alignment Length:2603 Identity:746/2603 - (28%)
Similarity:1126/2603 - (43%) Gaps:757/2603 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 SSMSPNQLRVS-----PNSSRIREAMPE---RPAMPLDLNTLRSISAWNLPMSIQAEYKKKGVVD 231
            ||.||..|..|     |...|..:|...   :|.:|........::.|.||.::..:|...||..
Human    27 SSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKK 91

  Fly   232 MFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKKVLLILPFISVVREKMF 296
            ||:||.|||...::| |..|||||||||||||||:|:|:||.|||..||.|.||||:||.:||.:
Human    92 MFEWQAECLLLGQVL-EGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKY 155

  Fly   297 YMQDLLTPAGYRVEGFYGGYTPPGGFESLHVAICTIEKANSIVNKLMEQGKLETIGMVVVDEVHL 361
            |:|.|....|.:|:|:.|..:|...|.||.:|:||||:||.::|:|:|:.|::.:|||||||:|:
Human   156 YLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHM 220

  Fly   362 ISDKGRGYILELLLAKILYMSRRNGL-----------QIQVITMSATLENVQLLQSWLDAELYIT 415
            :.|..|||:|||||.||.|::|::..           .:|::.|||||.|::|:.|||:||||.|
Human   221 LGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHT 285

  Fly   416 NYRPVALKEMIKVGTVIYDHRLKLVRDVAKQKVLLKGLENDSDDVALLCIETLLEGCSVIVFCPS 480
            ::|||.|.|.:|||..|||..:||||:. :..:.:||   |.|.|..||.||:.:..||::||||
Human   286 DFRPVPLLESVKVGNSIYDSSMKLVREF-EPMLQVKG---DEDHVVSLCYETICDNHSVLLFCPS 346

  Fly   481 KDWCENLAVQLATA---IHVQIKSETVLGQRLRTNLNPRAIAEVKQQLRDIPTGLDGVMSKAITY 542
            |.|||.||..:|..   :|.|.:......:.....|..:.:.||..|||.:|:|||.|:.|.:.:
Human   347 KKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPW 411

  Fly   543 ACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPARRVLIRSPLFGGKQMSSLTYRQ 607
            ..||||||||.|||||||.:|:.|.::||.||||||||||||||||:||:|:|||:.:..|||:|
Human   412 GVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQ 476

  Fly   608 MIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQPITSCL------DMDGSTHLKRALLEVI 666
            |:|||||.|.||:|||||||.......|..|:...|:|:.|||      ::.||  :.||:||:|
Human   477 MVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGS--MIRAILEII 539

  Fly   667 SSGVANTKEDIDFFVNCTLLSAQKAFHAKEKPPDEES-DANYINDALDFLVEYEFVR-LQRNEER 729
            ..|||:|.:|:..:..||.|:|......:....::|| ....|...:.:|:|.||:: .:.::..
Human   540 VGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGT 604

  Fly   730 ETAVYVATRLGAACLASSMPPTDGLILFAELQKSRRSFVLESELHAVYLVTPYSVCYQLQD---I 791
            |..||..|.||:|.|:||:.|.|.|.:||:||::.:.||||::||.:|||||     ..:|   |
Human   605 EGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTP-----MFEDWTTI 664

  Fly   792 DWLLYVHMWEKLSSPMKKVGELVGVRDAFLYKALRG----QTKLDYKQMQIHKRFYIALALEELV 852
            ||..:..:||||.:.||:|.|||||.:.||.:.::|    :|:..::||.|||||:.:|.|.:|:
Human   665 DWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLI 729

  Fly   853 NETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFCNSLQWSTLALIVSQFKDRLFFGIHRDLI 917
            :|.|:..:..||.|:||.:|||||.|:.:||::|.|.|.|.|..:.|::|||:.||.|||.|:|.
Human   730 SEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELC 794

  Fly   918 DLMRIPDLSQKRARALFDAGITSLVELAGADPVELEKVLYNSISFDSAKQHDHENADEAAKRNVV 982
            ||:|:..|:.:|||.|:.:|..::.:||.|:.||:|.:|.|::.|.||::...|..:...:|..:
Human   795 DLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNM 859

  Fly   983 RNFYITGKAGMTVSEAAKLLIGEARQFVQHEIGLGTIKWTQTQAGVEIASRAIHDGGEVDLHMSL 1047
            |..::||:.|:|..|||.|::.|||..:|.::....::|..............|...||..|..:
Human   860 RTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEHTFI 924

  Fly  1048 EEEQPPVKRKLSIEENGTANS----QKNPRLETVVDTQR-------------------------- 1082
            .:.:...|:..|..::.|..|    :.:|.:...::..|                          
Human   925 SQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQTCSIFRAR 989

  Fly  1083 ------------------GYKVDKNIA--------------NQSKM------------------- 1096
                              |...||.:.              |..||                   
Human   990 KRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDS 1054

  Fly  1097 -------------------NPNLKE----IDAQNKARRNSTAHMDNLN----------------- 1121
                               ||:|.|    :|.:....|||.....|::                 
Human  1055 SPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIK 1119

  Fly  1122 -------PISND---------------PCQ----------------------------NNVNV-- 1134
                   .::||               .||                            .|.||  
Human  1120 QNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYM 1184

  Fly  1135 -----------------KTAQPIISNLNDIQKQ------GSQI----------EKMKIN-----P 1161
                             :....|....|.|::|      .|.|          |::|:|     |
Human  1185 KHHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKP 1249

  Fly  1162 A-----------TVVCSPQLAN--------------------EEKPST----------------- 1178
            :           ||:.|..|.:                    :||..|                 
Human  1250 SHFQALGDDISRTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLV 1314

  Fly  1179 -----------SQSARRKLVNEGMAERRRV---------ALMK---IQQRT----QKE------- 1209
                       :||  .|::.:...|..::         .:|:   :||.:    |||       
Human  1315 LCDFEDSFYLDTQS--EKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPA 1377

  Fly  1210 ---------------------NQSKD----------QPIQAS------------------RSNQL 1225
                                 .||.|          .||..|                  ..:||
Human  1378 EQHPLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQL 1442

  Fly  1226 SS------------------PVNRTPANRWTQSE---NPNNEMNNS----------------QLP 1253
            :|                  |..|||..  .:.|   .|...:|.|                |||
Human  1443 NSFLQGYQTQETVKPVILLIPQKRTPTG--VEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLP 1505

  Fly  1254 RRNPRNQSPVP------------------------NANRTASRKV--SNAEEDLFMADDSFMLNT 1292
              :.:.:.|:|                        |.|:...:::  ||.|..:|...||..:..
Human  1506 --DMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVE 1568

  Fly  1293 GL-------------------AAALT--------------------AAESKIA----------SC 1308
            .|                   |..|:                    |.:||:.          |.
Human  1569 ALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSG 1633

  Fly  1309 TEADVIPS--------SQPKEPEVIGALTPHASRLKRSD-----------QLRSQRIQSPSPTPQ 1354
            ...|:.|.        |.|.|.|.:.::|.:.|.|.|.:           .|.::::|..|.:..
Human  1634 ASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSSN 1698

  Fly  1355 REIEIDLE---------------SKNESN-----------------------GVSSMEISDMSME 1381
            .|::..:|               .:.|||                       |:....::.....
Human  1699 NEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPVNPWKTN 1763

  Fly  1382 NPLMKNPLHLNAS------HIMS---------CSKVDET----------------ASSFSSIDII 1415
            |.|.....:|..|      |.:|         .|.:.:|                :||..|:.||
Human  1764 NVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTPASSSSESLSII 1828

  Fly  1416 DVCGHRNAFQAAIIEINNATRLGFSVG---LQAQAGKQKPLIGSNLLINQVAAAENREAAARERV 1477
            ||...:|.||..|.|.....|...|:.   :::....:...|||..          ::|::.:.:
Human  1829 DVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRF----------KQASSPQEI 1883

  Fly  1478 LFQVD-------DTNFISGVSFCLADNVAYYWNMQIDER---AAYQGVPTPLK-----------V 1521
            ..:.|       |...:.|::.|.....|||:::|.:::   .:...||..|.           :
Human  1884 PIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDPSLTLKDRMWYL 1948

  Fly  1522 QELCNLMARKDLTLVMHDGKEQLKMLRKAIPQLKRISAKLEDAKVANWLLQPDKTVNFLNMCQT- 1585
            |......:.|:.::|::|..:..|:|..:..  ..:....||.|||.|||.||.....|:...| 
Human  1949 QSCLRKESDKECSVVIYDFIQSYKILLLSCG--ISLEQSYEDPKVACWLLDPDSQEPTLHSIVTS 2011

  Fly  1586 FAPECTGLANLCGSGRGYSSYGLDTSSAILPRIRTAIESCVTLHILQG-----QTENLSRIGNGD 1645
            |.|....|.....:.:|..|.||:..|....|.|.::||.:..:.:..     |.|||..:    
Human  2012 FLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQKENLQDV---- 2072

  Fly  1646 LLKFFHDIEMPIQLTLCQMELVGFPAQKQRLQQLYQRMVAVMKKVETKIYEQHGSRFNLGSSQAV 1710
                |..:|||.|..|..:||.|........:.....|.|.:..:||:.|:..|..|:..||..:
Human  2073 ----FRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDI 2133

  Fly  1711 AKVLGLHRKA-----------------------KGR-------VTTSRQVLEKLNS--PISHLIL 1743
            |:||.|..|.                       .||       .:||:.||.||.:  |:..|||
Human  2134 AEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLIL 2198

  Fly  1744 GYRKLSGLLAKSIQPLM-ECC-----QADRIHGQSITYTATGRISMTEPNLQNVAKEFSIQ---- 1798
            .:|:::..:.|.:.||. |.|     ..:||:..|.::||||||:.||||:|||.::|.|:    
Human  2199 EWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTL 2263

  Fly  1799 ---------VGSDVV--------------------------------HISCRSPFMPTDESRCLL 1822
                     ||..::                                .||.|..|:|. ....:|
Human  2264 VGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPF-PGGSIL 2327

  Fly  1823 SADFCQLEMRILAHMSQDKALLEVMKSSQDLFIAIAAHWNKIEESEVTQDLRNSTKQVCYGIVYG 1887
            :||:.|||:|||||:|.|:.|::|:.:..|:|.:|||.|..||...|..|||...||:||||:||
Human  2328 AADYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYG 2392

  Fly  1888 MGMRSLAESLNCSEQEARMISDQFHQAYKGIRDYTTRVVNFARSKGFVETITGRRRYLENINSDV 1952
            ||.:||.|.:...|.:|....|.|...|.||..:.|..|...:..|||:||.||||||..|..:.
Human  2393 MGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNN 2457

  Fly  1953 EHLKNQAERQAVNSTIQGSAADIAKNAILKMEKNIERY---------REKLALGDNS-------- 2000
            .:.|..|||||:|:.:|||||||.|.|.:.::|.:|.:         ||.:...|.:        
Human  2458 PYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKRKL 2522

  Fly  2001 ---------VDLVMHLHDELIFEVPTGKAKKIAKVLSLTMENCVKLSVPLKVKLRIGRSWGEFKE 2056
                     ...::.|||||::||......::|:::...||:.|||||.||||::||.||||.|:
Human  2523 QGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKD 2587

  Fly  2057 VSV 2059
            ..|
Human  2588 FDV 2590

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-thetaNP_524333.1 BRR2 209..978 CDD:224125 359/797 (45%)
DEAD 251..404 CDD:278688 83/163 (51%)
HELICc 542..616 CDD:197757 51/73 (70%)
PolA 1489..2055 CDD:223820 216/694 (31%)
DNA_pol_A_theta 1668..2053 CDD:176475 163/493 (33%)
POLQNP_955452.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33 4/5 (80%)
BRR2 76..829 CDD:224125 350/764 (46%)
DEAD 96..274 CDD:278688 89/178 (50%)
DEAH box 216..219 2/2 (100%)
HELICc 412..485 CDD:197757 51/72 (71%)
Interaction with RAD51. /evidence=ECO:0000269|PubMed:25642963 847..894 15/46 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1060 2/25 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1594..1622 3/27 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1777..1797 2/19 (11%)
PolA 1900..2586 CDD:223820 216/696 (31%)
DnaQ_like_exo 1900..2085 CDD:299142 48/194 (25%)
DNA_pol_A_theta 2091..2585 CDD:176475 164/494 (33%)
Loop 1. /evidence=ECO:0000269|PubMed:21050863 2142..2177 3/34 (9%)
Loop 2. /evidence=ECO:0000269|PubMed:21050863, ECO:0000269|PubMed:25643323 2257..2322 8/65 (12%)
Loop 3. /evidence=ECO:0000269|PubMed:21050863 2491..2535 4/43 (9%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147131
Domainoid 1 1.000 364 1.000 Domainoid score I936
eggNOG 1 0.900 - - E1_COG0749
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H32727
Inparanoid 1 1.050 1000 1.000 Inparanoid score I298
Isobase 1 0.950 - 0 Normalized mean entropy S5818
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D103838at33208
OrthoFinder 1 1.000 - - FOG0001214
OrthoInspector 1 1.000 - - oto91599
orthoMCL 1 0.900 - - OOG6_101025
Panther 1 1.100 - - O PTHR10133
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2964
SonicParanoid 1 1.000 - - X4573
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.740

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