Protein Alignment PolQ and helq

DIOPT Version :10

• Sequence 1: NP_524333.1
• Gene: PolQ / 41571
• FlyBaseID: FBgn0002905
• Length: 2059
• Species: Drosophila melanogaster
• Sequence 2: XP_002939628.2
• Gene: helq / 100485183
• XenbaseID: XB-GENE-993428
• Length: 1000
• Species: Xenopus tropicalis
• Alignment Length: 1084
• Identity: 321/1084 - (29%)
• Similarity: 523/1084 - (48%)
• Gaps: 195/1084 - (17%)

  Fly    10 GNSTLMALEKGMQADDKENAQPGNGNIQVQSAGNEVNSEIQEINSEFFRDEFSYEVNQAHKPAEQ 74
            |:|.|...:|.|.:.:.:|.              :.:...:::..|:  |.|:.:::.
 Frog    22 GHSLLTPTKKRMNSREDDNI--------------KCHESDEDLFGEY--DSFAEDLDL------- 63

  Fly    75 SVVNVSQVQQHMAVVSNQDSEDQSRSSALNDQICTQSSFEGEDAGADAVLDQPNLDENSFLCPAQ 139
                ::||         .|.|:|.:....|...|:.|....||         ||.:|:.......
 Frog    64 ----LAQV---------DDLENQEKLEQCNTFPCSSSDQRPED---------PNHNEDKIKHSTS 106

  Fly   140 DEEAS--------------EQLK------------------EDI-LHSHSVLAKQEFYQEISQVT 171
            .|.:|              .:||                  ||. |.:.....|....|:||::.
 Frog   107 GELSSLFQSGQTARSLRITNELKGKRKDFLDVIPCSQLPCNEDSNLRTGFPCVKANGAQDISRMD 171

  Fly   172 QN-------LSSMSPNQLRVSPNSSRIRE-------------AMPERPAMPLDLNTLRSISAWNL 216
            :.       .|:::.|....:|..||.:|             ....:.:..|||...     :.|
 Frog   172 KRKSLKDHLKSTLAVNAKVQTPRISRTKELKKAILLEEFDVAQQTVKTSCDLDLGPF-----YGL 231

  Fly   217 PMSIQ-AEYKKKGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKK 280
            |..:: ..|:.:.:..::|||..||:. :.:.|..||:||.|||.|||||:|||:|:.:|.|.|.
 Frog   232 PSRVRDLIYQFRRIKKLYDWQHTCLTL-QSIKERKNLIYSLPTSGGKTLVAEILVLQELLCRQKD 295

  Fly   281 VLLILPFISVVREKMFYMQDLLTPAGYRVEGFYG--GYTPP---GGFESLHVAICTIEKANSIVN 340
            ||:|||::::|:||:..:........:.||.:.|  |..||   ...:||::|  ||||.:|::|
 Frog   296 VLMILPYVAIVQEKVRGLASFGVELDFLVEEYAGSRGRFPPIKRRTKKSLYIA--TIEKGHSLIN 358

  Fly   341 KLMEQGKLETIGMVVVDEVHLISDKGRGYILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQ 405
            .|:|.|::..:|::||||:|::.:..||.|||:.|:||||.|    ..||:|.|||||.||..||
 Frog   359 SLIETGRINDLGLIVVDELHMLGEGSRGAILEMTLSKILYTS----TSIQIIGMSATLNNVAELQ 419

  Fly   406 SWLDAELYITNYRPVALKEMIKVGTVIYDHRLKLVRDVAKQKVLLKGLEN----------DSDDV 460
            ::|.||.|..|:|||.|||.:||...||:     |...|:..:....|.|          |.|.|
 Frog   420 NFLKAEYYTNNFRPVELKEFVKVRDCIYE-----VDSNAENNLTFSRLLNYKYSNNMMKIDPDHV 479

  Fly   461 ALLCIETLLEGCSVIVFCPSKDWCENLAVQLA---TAIHVQIKSETVLGQRLRTNLNPRAIAEVK 522
            ..|..| ::...|.:||||:|..|||:|..:.   ..::|:.:      :..:.||    ||:
 Frog   480 VALVTE-VIPANSCLVFCPTKKNCENVAEMICKYLNKLYVEHR------EAEKKNL----IAD-- 531

  Fly   523 QQLRDIPTG-LDGVMSKAITYACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPAR 586
              |::|..| |..|:.:.|.:..|:||:|||::||.:||.::.||.|.:|..||||::|||||||
 Frog   532 --LKNIGNGVLCSVLKRTIPFGIAYHHSGLTSDERKLIEEAYSAGVLCLLACTSTLAAGVNLPAR 594

  Fly   587 RVLIRSPLFGGKQMSSLTYRQMIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQPITSCLD 651
            ||::|:|......:....|:||:|||||.|.|:.||||||..|.:..:.::|:...::...|.|.
 Frog   595 RVILRAPYVANDFLKRAQYKQMVGRAGRAGIDSAGESILIIQEKDKELVQELISKPMENCYSNLM 659

  Fly   652 MDGSTHLKRALLEVISSGVANTKEDIDFFVNCTLLSAQKAFHAKEKPPDEESDANYIN---DALD 713
            .:.....:..||.:|...:..|.|:|..||:|||.|.|::...|.|        |.::   ::|:
 Frog   660 HNSGKDFQSLLLSLIGLKITKTAEEIYSFVSCTLFSVQQSVLCKAK--------NLLDVTKESLE 716

  Fly   714 FLVEYEFVRLQRNEERETAVYVATRLGAACLASSMPPTDGLILFAELQKSRRSFVLESELHAVYL 778
            .||:...:..:...|.|..::..::||.|.....:......:|:::|.:.....||||.||.:||
 Frog   717 CLVDKGLICGKTCSETEQYIFQVSKLGHATYKGCIDLACYDLLYSDLNRGLEGLVLESFLHLLYL 781

  Fly   779 VTPYSVCYQLQDIDWLLYVHMWEKLSSPMKKVGELVGVRDAFLYKALRGQTKLDYKQMQIHKRFY 843
            |.||.:..:... ||::|...:..||...:||...||:.::||.:...|||........:..|.|
 Frog   782 VIPYDLVGKFNP-DWMIYFRQYNSLSPVEQKVAASVGIPESFLARKASGQTVKTSANNMVVNRLY 845

  Fly   844 IALALEELVNETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFCNSLQ--WSTLALIVSQFKD 906
            ::..|..|:.||.|..|..|:...||.||:|...:::|:..|..||..|.  |:..:|: .:...
 Frog   846 LSFILYTLLKETDIWRVSAKFSIPRGTLQNLLSSSASFSSSVLHFCEELDEFWAYKSLL-QELTK 909

  Fly   907 RLFFGIHRDLIDLMRIPDLSQKRARALFDAGITSLVELAGADP-VELEKVLYNSISFDSAKQHDH 970
            :|.:.:..:||.||.:..:.:.||:.|::||.|||..||.||| |.::|:  ..:|...|||
 Frog   910 KLTYCVKSELIPLMEVAGVMEARAKQLYNAGYTSLAHLANADPEVMVKKI--EHLSRHQAKQ--- 969

  Fly   971 ENADEAAKRNVVRNFYITGKAGMTVSEAAKLLIGEARQFVQHEI 1014
                                    :..:||:|:.|..:.:|.|:
 Frog   970 ------------------------IVFSAKMLVNEKAEALQEEV 989

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolQ	NP_524333.1	BRR2	216..779	CDD:440817	210/585 (36%)
		DNA_pol_A_theta	1668..2053	CDD:176475
helq	XP_002939628.2	DEXHc_POLQ-like	231..433	CDD:350784	88/208 (42%)
		BRR2	245..796	CDD:440817	212/586 (36%)
		COG2251	<921..>1000	CDD:441852	27/98 (28%)