DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-theta and helq

DIOPT Version :9

Sequence 1:	NP_524333.1	Gene:	DNApol-theta / 41571	FlyBaseID:	FBgn0002905	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	XP_002939628.2	Gene:	helq / 100485183	XenbaseID:	XB-GENE-993428	Length:	1000	Species:	Xenopus tropicalis

Alignment Length:	1084	Identity:	321/1084 - (29%)
Similarity:	523/1084 - (48%)	Gaps:	195/1084 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GNSTLMALEKGMQADDKENAQPGNGNIQVQSAGNEVNSEIQEINSEFFRDEFSYEVNQAHKPAEQ 74
            |:|.|...:|.|.:.:.:|.              :.:...:::..|:  |.|:.:::.
Frog    22 GHSLLTPTKKRMNSREDDNI--------------KCHESDEDLFGEY--DSFAEDLDL------- 63

  Fly    75 SVVNVSQVQQHMAVVSNQDSEDQSRSSALNDQICTQSSFEGEDAGADAVLDQPNLDENSFLCPAQ 139
                ::||         .|.|:|.:....|...|:.|....||         ||.:|:.......
Frog    64 ----LAQV---------DDLENQEKLEQCNTFPCSSSDQRPED---------PNHNEDKIKHSTS 106

  Fly   140 DEEAS--------------EQLK------------------EDI-LHSHSVLAKQEFYQEISQVT 171
            .|.:|              .:||                  ||. |.:.....|....|:||::.
Frog   107 GELSSLFQSGQTARSLRITNELKGKRKDFLDVIPCSQLPCNEDSNLRTGFPCVKANGAQDISRMD 171

  Fly   172 QN-------LSSMSPNQLRVSPNSSRIRE-------------AMPERPAMPLDLNTLRSISAWNL 216
            :.       .|:::.|....:|..||.:|             ....:.:..|||...     :.|
Frog   172 KRKSLKDHLKSTLAVNAKVQTPRISRTKELKKAILLEEFDVAQQTVKTSCDLDLGPF-----YGL 231

  Fly   217 PMSIQ-AEYKKKGVVDMFDWQVECLSKPRLLFEHCNLVYSAPTSAGKTLVSEILMLKTVLERGKK 280
            |..:: ..|:.:.:..::|||..||:. :.:.|..||:||.|||.|||||:|||:|:.:|.|.|.
Frog   232 PSRVRDLIYQFRRIKKLYDWQHTCLTL-QSIKERKNLIYSLPTSGGKTLVAEILVLQELLCRQKD 295

  Fly   281 VLLILPFISVVREKMFYMQDLLTPAGYRVEGFYG--GYTPP---GGFESLHVAICTIEKANSIVN 340
            ||:|||::::|:||:..:........:.||.:.|  |..||   ...:||::|  ||||.:|::|
Frog   296 VLMILPYVAIVQEKVRGLASFGVELDFLVEEYAGSRGRFPPIKRRTKKSLYIA--TIEKGHSLIN 358

  Fly   341 KLMEQGKLETIGMVVVDEVHLISDKGRGYILELLLAKILYMSRRNGLQIQVITMSATLENVQLLQ 405
            .|:|.|::..:|::||||:|::.:..||.|||:.|:||||.|    ..||:|.|||||.||..||
Frog   359 SLIETGRINDLGLIVVDELHMLGEGSRGAILEMTLSKILYTS----TSIQIIGMSATLNNVAELQ 419

  Fly   406 SWLDAELYITNYRPVALKEMIKVGTVIYDHRLKLVRDVAKQKVLLKGLEN----------DSDDV 460
            ::|.||.|..|:|||.|||.:||...||:     |...|:..:....|.|          |.|.|
Frog   420 NFLKAEYYTNNFRPVELKEFVKVRDCIYE-----VDSNAENNLTFSRLLNYKYSNNMMKIDPDHV 479

  Fly   461 ALLCIETLLEGCSVIVFCPSKDWCENLAVQLA---TAIHVQIKSETVLGQRLRTNLNPRAIAEVK 522
            ..|..| ::...|.:||||:|..|||:|..:.   ..::|:.:      :..:.||    ||:
Frog   480 VALVTE-VIPANSCLVFCPTKKNCENVAEMICKYLNKLYVEHR------EAEKKNL----IAD-- 531

  Fly   523 QQLRDIPTG-LDGVMSKAITYACAFHHAGLTTEERDIIEASFKAGALKVLVATSTLSSGVNLPAR 586
              |::|..| |..|:.:.|.:..|:||:|||::||.:||.::.||.|.:|..||||::|||||||
Frog   532 --LKNIGNGVLCSVLKRTIPFGIAYHHSGLTSDERKLIEEAYSAGVLCLLACTSTLAAGVNLPAR 594

  Fly   587 RVLIRSPLFGGKQMSSLTYRQMIGRAGRMGKDTLGESILICNEINARMGRDLVVSELQPITSCLD 651
            ||::|:|......:....|:||:|||||.|.|:.||||||..|.:..:.::|:...::...|.|.
Frog   595 RVILRAPYVANDFLKRAQYKQMVGRAGRAGIDSAGESILIIQEKDKELVQELISKPMENCYSNLM 659

  Fly   652 MDGSTHLKRALLEVISSGVANTKEDIDFFVNCTLLSAQKAFHAKEKPPDEESDANYIN---DALD 713
            .:.....:..||.:|...:..|.|:|..||:|||.|.|::...|.|        |.::   ::|:
Frog   660 HNSGKDFQSLLLSLIGLKITKTAEEIYSFVSCTLFSVQQSVLCKAK--------NLLDVTKESLE 716

  Fly   714 FLVEYEFVRLQRNEERETAVYVATRLGAACLASSMPPTDGLILFAELQKSRRSFVLESELHAVYL 778
            .||:...:..:...|.|..::..::||.|.....:......:|:::|.:.....||||.||.:||
Frog   717 CLVDKGLICGKTCSETEQYIFQVSKLGHATYKGCIDLACYDLLYSDLNRGLEGLVLESFLHLLYL 781

  Fly   779 VTPYSVCYQLQDIDWLLYVHMWEKLSSPMKKVGELVGVRDAFLYKALRGQTKLDYKQMQIHKRFY 843
            |.||.:..:... ||::|...:..||...:||...||:.::||.:...|||........:..|.|
Frog   782 VIPYDLVGKFNP-DWMIYFRQYNSLSPVEQKVAASVGIPESFLARKASGQTVKTSANNMVVNRLY 845

  Fly   844 IALALEELVNETPINVVVHKYKCHRGMLQSLQQMASTFAGIVTAFCNSLQ--WSTLALIVSQFKD 906
            ::..|..|:.||.|..|..|:...||.||:|...:::|:..|..||..|.  |:..:|: .:...
Frog   846 LSFILYTLLKETDIWRVSAKFSIPRGTLQNLLSSSASFSSSVLHFCEELDEFWAYKSLL-QELTK 909

  Fly   907 RLFFGIHRDLIDLMRIPDLSQKRARALFDAGITSLVELAGADP-VELEKVLYNSISFDSAKQHDH 970
            :|.:.:..:||.||.:..:.:.||:.|::||.|||..||.||| |.::|:  ..:|...|||
Frog   910 KLTYCVKSELIPLMEVAGVMEARAKQLYNAGYTSLAHLANADPEVMVKKI--EHLSRHQAKQ--- 969

  Fly   971 ENADEAAKRNVVRNFYITGKAGMTVSEAAKLLIGEARQFVQHEI 1014
                                    :..:||:|:.|..:.:|.|:
Frog   970 ------------------------IVFSAKMLVNEKAEALQEEV 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-theta	NP_524333.1	BRR2	209..978	CDD:224125	273/794 (34%)
		DEAD	251..404	CDD:278688	72/157 (46%)
		HELICc	542..616	CDD:197757	37/73 (51%)
		PolA	1489..2055	CDD:223820
		DNA_pol_A_theta	1668..2053	CDD:176475
helq	XP_002939628.2	PRK02362	231..957	CDD:235032	268/762 (35%)
helq	XP_002939628.2	DEXHc_POLQ-like	231..433	CDD:350784	88/208 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D103838at33208
OrthoFinder	1	1.000	-	-		FOG0001214
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920