DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp1 and POTEI

DIOPT Version :9

Sequence 1:	NP_524331.2	Gene:	Arp1 / 41566	FlyBaseID:	FBgn0011745	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001358855.1	Gene:	POTEI / 653269	HGNCID:	37093	Length:	1097	Species:	Homo sapiens

Alignment Length:	370	Identity:	193/370 - (52%)
Similarity:	266/370 - (71%)	Gaps:	7/370 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VVIDNGSGVIKAGFAGEHIPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKAEEHRGLLSIRYPME 76
            :|||||||:.||||||:..|:..||:.:|||:...:|.|..:.:.:||.:|:..||:|:::||||
Human   730 LVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRQQGMMGGMHQKESYVGKEAQSKRGILTLKYPME 794

  Fly    77 HGIVTDWNDMERIWSYIYSKEQLATFTEDHPVLLTEAPLNPRRNREKAAEFFFEGINAPALFVSM 141
            |||:|:|:|||:||.:.:..| |....|:||:|||||||||:.||||..:..||..|.||::|::
Human   795 HGIITNWDDMEKIWHHTFYNE-LRVAPEEHPILLTEAPLNPKANREKMTQIMFETFNTPAMYVAI 858

  Fly   142 QAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLKTLIRREGFNFR 206
            ||:||||.:||.||:|:||||||||.||||:|.|:||:.:|:|:|||::|.||..::...|:.|.
Human   859 QAMLSLYTSGRTTGIVMDSGDGVTHTVPIYDGNALPHATLRLDLAGRELTDYLMKILTERGYRFT 923

  Fly   207 STAEFEIVRSIKEKVCYLATNPQKE-----ETVETEKFAYKLPDGKIFEIGPARFRAPEVLFRPD 266
            :.||.||||.||||:||:|.:.::|     .:...|| :|:||||::..||...||.||.||:|.
Human   924 TMAEREIVRDIKEKLCYVALDFEQEMAMAASSSSLEK-SYELPDGQVITIGNEWFRCPEALFQPC 987

  Fly   267 LLGEECEGIHDVLMYSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKDLKIRIA 331
            .||.|..|||:....||.|||:|:||.||.|.|||||:|::.|...|:..|:...:...|||||.
Human   988 FLGMESCGIHETTFNSIMKSDVDIRKDLYTNTVLSGGTTMYPGMAHRMQKEIAALAPSMLKIRII 1052

  Fly   332 APQERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHRKTF 376
            ||.:|.||.|:||||||||.||::|||||:||:|.|...||||.|
Human  1053 APPKRKYSVWVGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp1	NP_524331.2	NBD_sugar-kinase_HSP70_actin	5..376	CDD:302596	192/368 (52%)
Arp1	NP_524331.2	ACTIN	9..376	CDD:214592	192/368 (52%)
POTEI	NP_001358855.1	Ank_2	158..>361	CDD:393464
		ANK repeat	174..203	CDD:293786
		ANK repeat	205..236	CDD:293786
		ANK repeat	238..269	CDD:293786
		ANK repeat	271..302	CDD:293786
		ANK repeat	304..335	CDD:293786
		CCDC144C	670..>723	CDD:373382
		NBD_sugar-kinase_HSP70_actin	723..1097	CDD:388382	192/368 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D649708at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820