Protein Alignment Arp1 and ACTA1

DIOPT Version :10

• Sequence 1: NP_524331.2
• Gene: Arp1 / 41566
• FlyBaseID: FBgn0011745
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_001091.1
• Gene: ACTA1 / 58
• HGNCID: 129
• Length: 377
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 199/370 - (53%)
• Similarity: 271/370 - (73%)
• Gaps: 7/370 - (1%)

  Fly    12 VVIDNGSGVIKAGFAGEHIPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKAEEHRGLLSIRYPME 76
            :|.|||||::||||||:..|:..||:.:|||:|..||.|..:.|.:||.:|:..||:|:::||:|
Human    10 LVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIE 74

  Fly    77 HGIVTDWNDMERIWSYIYSKEQLATFTEDHPVLLTEAPLNPRRNREKAAEFFFEGINAPALFVSM 141
            |||:|:|:|||:||.:.:..| |....|:||.|||||||||:.||||..:..||..|.||::|::
Human    75 HGIITNWDDMEKIWHHTFYNE-LRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAI 138

  Fly   142 QAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLKTLIRREGFNFR 206
            ||||||||:||.||:||||||||||.||||||:|:||:|||:|:||||:|.||..::...|::|.
Human   139 QAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFV 203

  Fly   207 STAEFEIVRSIKEKVCYLATNPQKE-----ETVETEKFAYKLPDGKIFEIGPARFRAPEVLFRPD 266
            :|||.||||.||||:||:|.:.:.|     .:...|| :|:||||::..||..|||.||.||:|.
Human   204 TTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK-SYELPDGQVITIGNERFRCPETLFQPS 267

  Fly   267 LLGEECEGIHDVLMYSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKDLKIRIA 331
            .:|.|..|||:....||.|.|:|:||.||.|.|:|||:|::.|..||:..|:...:...:||:|.
Human   268 FIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKII 332

  Fly   332 APQERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHRKTF 376
            ||.||.||.|:||||||||.||::|||:|:||:|.|...||||.|
Human   333 APPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Arp1	NP_524331.2	ASKHA_NBD_Arp1	9..375	CDD:466820	197/367 (54%)
ACTA1	NP_001091.1	ASKHA_NBD_actin	8..372	CDD:466823	194/363 (53%)
		Interaction with alpha-actinin. /evidence=ECO:0000250|UniProtKB:P68135	112..125		7/12 (58%)
		Interaction with alpha-actinin. /evidence=ECO:0000250|UniProtKB:P68135	360..372		5/11 (45%)