DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp1 and actr1b

DIOPT Version :9

Sequence 1:	NP_524331.2	Gene:	Arp1 / 41566	FlyBaseID:	FBgn0011745	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_998537.1	Gene:	actr1b / 406681	ZFINID:	ZDB-GENE-040426-2695	Length:	376	Species:	Danio rerio

Alignment Length:	376	Identity:	293/376 - (77%)
Similarity:	343/376 - (91%)	Gaps:	0/376 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEPYDVVVNQPVVIDNGSGVIKAGFAGEHIPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKAEEH 65
            ||.||::.|||||||||||||||||||:.|||..||||:||||||||||||||||:|:|||||||
Zfish     1 MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHVRVMAGALEGDLFIGPKAEEH 65

  Fly    66 RGLLSIRYPMEHGIVTDWNDMERIWSYIYSKEQLATFTEDHPVLLTEAPLNPRRNREKAAEFFFE 130
            |||||:|||||||||.|||||||||.|:||||||.||:|:||||||||||||.:|||:|||.|||
Zfish    66 RGLLSVRYPMEHGIVKDWNDMERIWQYVYSKEQLQTFSEEHPVLLTEAPLNPSKNRERAAEVFFE 130

  Fly   131 GINAPALFVSMQAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLK 195
            ..|.||||:|||||||||||||.||||||:|||||||||||||||:||||||||||||||:|||:
Zfish   131 TFNVPALFISMQAVLSLYATGRTTGVVLDAGDGVTHAVPIYEGFAIPHSIMRVDIAGRDVSRYLR 195

  Fly   196 TLIRREGFNFRSTAEFEIVRSIKEKVCYLATNPQKEETVETEKFAYKLPDGKIFEIGPARFRAPE 260
            .|:|:||::|.::||||:||:|||:.|||:.||||:||:||||..|.||||...:||||||||||
Zfish   196 LLLRKEGYDFHTSAEFEVVRTIKERACYLSLNPQKDETLETEKAQYTLPDGSTLDIGPARFRAPE 260

  Fly   261 VLFRPDLLGEECEGIHDVLMYSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKD 325
            :||||||:|:|.||||:||.::|:|||||||:.|:.||||||||||.||||||||||:||.:.||
Zfish   261 LLFRPDLIGDESEGIHEVLAFAIQKSDMDLRRTLFSNIVLSGGSTLLKGFGDRLLSEVKKLAPKD 325

  Fly   326 LKIRIAAPQERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHRKTF 376
            :||:|:||||||||||:|||||||||||||||:||:||||:..:|:|||||
Zfish   326 VKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDRARAIHRKTF 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp1	NP_524331.2	NBD_sugar-kinase_HSP70_actin	5..376	CDD:302596	288/370 (78%)
Arp1	NP_524331.2	ACTIN	9..376	CDD:214592	287/366 (78%)
actr1b	NP_998537.1	NBD_sugar-kinase_HSP70_actin	5..376	CDD:418402	288/370 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594792
Domainoid	1	1.000	608	1.000	Domainoid score	I184
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	627	1.000	Inparanoid score	I837
OMA	1	1.010	-	-		QHG55293
OrthoDB	1	1.010	-	-		D306902at33208
OrthoFinder	1	1.000	-	-		FOG0000057
OrthoInspector	1	1.000	-	-		oto39818
orthoMCL	1	0.900	-	-		OOG6_103845
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4323
SonicParanoid	1	1.000	-	-		X3841
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800