DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Arp1 and POTED

DIOPT Version :9

Sequence 1:NP_524331.2 Gene:Arp1 / 41566 FlyBaseID:FBgn0011745 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_778146.2 Gene:POTED / 317754 HGNCID:23822 Length:584 Species:Homo sapiens


Alignment Length:432 Identity:74/432 - (17%)
Similarity:130/432 - (30%) Gaps:163/432 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GSGVIKAGFAGEH-------------------IPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKA 62
            |||....|.:|:|                   .|.||     |..|.   ..||. ||.      
Human    74 GSGTSNVGTSGDHENSFMKMLRSKMGKWCCHCFPCCR-----GSGKS---NVGAW-GDY------ 123

  Fly    63 EEHRGLLSIRYPMEHGIVTDWNDMERI-----WSYIYSKEQLATFTEDHPVLLTEAPLNPRRNRE 122
             :|...:..||.:..      .|::::     |..:..|:.:        |:|.:..:| :|::|
Human   124 -DHSAFMEPRYHIRR------EDLDKLHRAAWWGKVPRKDLI--------VMLRDTDMN-KRDKE 172

  Fly   123 KAAEFFFEGINAPALFVSM----------------------------QAVLSLYATGRVTGVVLD 159
            |.........|..:..|.:                            :.||.|...|....:..:
Human   173 KRTALHLASANGNSEVVQLLLDRRCQLNVLDNKKRTALIKAIQCQEDECVLMLLEHGADRNIPDE 237

  Fly   160 SGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLKTLIRREGFNFRSTAEFEIVRSIKEKVC-- 222
            .|:...|.....|...|..:::   :.|.|:                         ..|.| |  
Human   238 YGNTALHYAIYNEDKLMAKALL---LYGADI-------------------------ESKNK-CGL 273

  Fly   223 ---YLATNPQKEETVETEKFAYKLPDGKIFEIGPARFRAPEVLFRPDLLGEECEG----IHDVLM 280
               .|..:.||::.|   ||..|         ..|.....:...|..|:...|.|    ::.:|.
Human   274 TPLLLGVHEQKQQVV---KFLIK---------KKANLNVLDRYGRTALILAVCCGSASIVNLLLE 326

  Fly   281 YSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKDLKIRIAAPQERLYSTWMGGS 345
            .:::.|..||.....:...:|....:.    ..|||:.|:.....:....:.|::.|.       
Human   327 QNVDVSSQDLSGQTAREYAVSSHHHVI----CELLSDYKEKQMLKISSENSNPEQDLK------- 380

  Fly   346 ILASLDTFKKMWISK------------------REYEEEGQK 369
             |.|.:..:::.:|:                  ||.|||.:|
Human   381 -LTSEEESQRLKVSENSQPEKMSQEPEINKDCDREVEEEIKK 421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Arp1NP_524331.2 NBD_sugar-kinase_HSP70_actin 5..376 CDD:302596 74/432 (17%)
ACTIN 9..376 CDD:214592 74/432 (17%)
POTEDNP_778146.2 Ank_4 143..193 CDD:290365 10/58 (17%)
ANK 167..292 CDD:238125 25/157 (16%)
ANK 1 172..201 4/28 (14%)
ANK repeat 174..203 CDD:293786 2/28 (7%)
Ank_2 177..269 CDD:289560 12/119 (10%)
ANK repeat 205..236 CDD:293786 4/30 (13%)
ANK 2 205..234 4/28 (14%)
ANK 233..357 CDD:238125 26/168 (15%)
ANK repeat 238..269 CDD:293786 6/58 (10%)
ANK 3 238..267 6/56 (11%)
Ank_2 243..335 CDD:289560 22/132 (17%)
ANK repeat 271..302 CDD:293786 9/42 (21%)
ANK 4 271..300 9/40 (23%)
ANK repeat 304..335 CDD:293786 6/30 (20%)
ANK 5 304..333 5/28 (18%)
ANK 6 337..366 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..502 11/61 (18%)
SH3_and_anchor <440..556 CDD:275056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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