DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Arp1 and Actl11

DIOPT Version :9

Sequence 1:	NP_524331.2	Gene:	Arp1 / 41566	FlyBaseID:	FBgn0011745	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001019959.2	Gene:	Actl11 / 316000	RGDID:	1310036	Length:	1218	Species:	Rattus norvegicus

Alignment Length:	383	Identity:	133/383 - (34%)
Similarity:	203/383 - (53%)	Gaps:	44/383 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PYDVVVNQPVVIDNGSGVIKAGFAGEHIPKCRFPNYI--------GRPKHVRVMAGALEGDIFVG 59
            ||..:.  .:|||.|:|..|.|.|.|:......|:.:        |:|::|
  Rat   865 PYQKMA--AIVIDTGTGFTKCGLAQENHVLSVVPSQVQMLQHPPQGQPQYV-------------- 913

  Fly    60 PKAEEHR-GLLSIRYPMEHGIVTDWNDMERIWSYI-YSKEQLATFTEDHPVLLTEAPLNPRRNRE 122
              ..||: |..|:   :..|:|:||:.:|.:|.:: |.|  |....|:..||:.::|::||.|||
  Rat   914 --VPEHQEGSYSV---LNRGVVSDWDALEVLWQHLFYCK--LRVQPEEMAVLVADSPISPRTNRE 971

  Fly   123 KAAEFFFEGINAPALFVSMQAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAG 187
            |.||..||..:.||:....||:|:|||.||.||:|:.||.|.::..||..|...|....|:|:||
  Rat   972 KVAEILFERFHVPAMQTVHQALLTLYAYGRTTGLVVGSGHGTSYVAPIITGDLAPLDTYRLDVAG 1036

  Fly   188 RDVTRYLKTLIRREGFNFRSTAEFEIVRSIKEKVCYLA--TNPQKEETVETEKFAYKLPDGKIFE 250
            .|:|.||..|:...|   .|..:..|||.|||..||:|  |..:........:..:.|||..:..
  Rat  1037 ADLTDYLAQLLMSGG---HSPPKGGIVRQIKEACCYVAMDTTTEMARNQSQVQVDFVLPDKHVIT 1098

  Fly   251 IGPARFRAPEVLFRPDLLGEECEGIHDVLMYSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLL 315
            :|..||..||.||:|:|||....|:..:.:.||.:.::..::.|..|:||.|||||..||.:|:.
  Rat  1099 LGSERFCCPEALFQPNLLGLNQLGLPQLALLSISRLEVKQQEQLLANVVLEGGSTLINGFPERMR 1163

  Fly   316 SELKKHSAKDLKIRIAAPQERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHR 373
            .||...:.      :.....|..:.|:||||:|..|:|:.:|:|:|||||||..|:::
  Rat  1164 QELGPGAT------VLGSPHRAVAAWLGGSIMACRDSFQSLWLSRREYEEEGPWAIYK 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp1	NP_524331.2	NBD_sugar-kinase_HSP70_actin	5..376	CDD:302596	131/381 (34%)
Arp1	NP_524331.2	ACTIN	9..376	CDD:214592	131/377 (35%)
Actl11	NP_001019959.2	PHA03247	<200..485	CDD:223021
Actl11	NP_001019959.2	NBD_sugar-kinase_HSP70_actin	871..1215	CDD:418402	131/373 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900