DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Arp1 and POTEH

DIOPT Version :9

Sequence 1:NP_524331.2 Gene:Arp1 / 41566 FlyBaseID:FBgn0011745 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_001129685.1 Gene:POTEH / 23784 HGNCID:133 Length:545 Species:Homo sapiens


Alignment Length:424 Identity:75/424 - (17%)
Similarity:136/424 - (32%) Gaps:137/424 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GSGVIKAGFAGEH-------------------IPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKA 62
            |||....|.:|:|                   .|.||     |..|:.....|..:...|:.|:.
Human   111 GSGKSNVGTSGDHDDSAMKTLRSKMGKWCCHCFPCCR-----GSGKNKVGPWGDYDDSAFMEPRY 170

  Fly    63 EEHRGLLSIRYPMEHGIVTDWNDMERI-----WSYIYSKEQLATFTEDHPVLLTEAPLNPRRNRE 122
            ...|                 .|::::     |..:..|:.:        |:|.:..:| :::::
Human   171 HVRR-----------------EDLDKLHRAAWWGKVPRKDLI--------VMLKDTDMN-KKDKQ 209

  Fly   123 KAAEFFFEGINAPALFVSMQAVLSLYATGRVTGVVLDS--GDGVTHAVPI--------------- 170
            |.........|..:      .|:.|....|....:||:  ...:|.||..               
Human   210 KRTALHLASANGNS------EVVKLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTD 268

  Fly   171 ------YEGFAMPHSIMRVDIAGRDVTRYLKTLIRREGFNFRSTAEFEIVRSIKEKVCYLATNPQ 229
                  |...|:.::|...|       :.:...:...|.:..|..:..:...:      |..:.|
Human   269 PNIPDEYGNTALHYAIYNED-------KLMAKALLLYGADIESKNKHGLTPLL------LGVHEQ 320

  Fly   230 KEETVETEKFAYKLPDGKIFEIGPARFRAPEVLFRPDLLGEECEG----IHDVLMYSIEKSDMDL 290
            |::.|   ||..|         ..|...|.:...|..|:...|.|    :..:|..:|:.|..||
Human   321 KQQVV---KFLIK---------KKANLNALDRYGRTALILAVCCGSASIVSLLLEQNIDVSSQDL 373

  Fly   291 RKMLYQNIVLSGGSTLFKGFGDRLLSELKK-----------HSAKDLKIRIAAPQERLYSTWMGG 344
            .....:...:|....:.    .:|||:.|:           :..:|||:......:||    .|.
Human   374 SGQTAREYAVSSRHNVI----CQLLSDYKEKQILKVSSENSNPEQDLKLTSEEESQRL----KGS 430

  Fly   345 SILASLDTFKKMWISK---REYEEEGQKAVHRKT 375
            ......:..::..|:|   |:.|||.:|  |..|
Human   431 ENSQPEEMSQEPEINKGGDRKVEEEMKK--HGST 462

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Arp1NP_524331.2 NBD_sugar-kinase_HSP70_actin 5..376 CDD:302596 75/424 (18%)
ACTIN 9..376 CDD:214592 75/424 (18%)
POTEHNP_001129685.1 Ank_4 180..230 CDD:290365 9/64 (14%)
ANK 1 180..208 5/36 (14%)
ANK 204..329 CDD:238125 23/147 (16%)
ANK 2 209..238 5/34 (15%)
ANK repeat 211..240 CDD:293786 4/34 (12%)
Ank_2 214..306 CDD:289560 15/104 (14%)
ANK repeat 242..273 CDD:293786 3/30 (10%)
ANK 3 242..271 3/28 (11%)
ANK 270..394 CDD:238125 25/152 (16%)
ANK repeat 275..306 CDD:293786 6/37 (16%)
ANK 4 275..304 5/35 (14%)
Ank_2 280..372 CDD:289560 20/116 (17%)
ANK repeat 308..339 CDD:293786 9/48 (19%)
ANK 5 308..337 8/46 (17%)
ANK repeat 341..372 CDD:293786 7/30 (23%)
ANK 6 341..370 6/28 (21%)
ANK 7 374..404 5/33 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..524 15/63 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.