DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp1 and Actl7b

DIOPT Version :9

Sequence 1:	NP_524331.2	Gene:	Arp1 / 41566	FlyBaseID:	FBgn0011745	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_079547.2	Gene:	Actl7b / 11471	MGIID:	1343053	Length:	418	Species:	Mus musculus

Alignment Length:	367	Identity:	142/367 - (38%)
Similarity:	209/367 - (56%)	Gaps:	7/367 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VVIDNGSGVIKAGFAGEHIPKCRFPNYIG-RPKHVRVMAGALEGDIFVGPKAEEHRGLLSIRYPM 75
            :|||.||...|.|:|||..|.....:.:| |...:...||....:.:||.:.......|.:..|:
Mouse    54 LVIDLGSQYCKCGYAGEPRPTYFISSTVGKRSAEMAADAGDNFKETYVGHELLNMEASLKLVNPL 118

  Fly    76 EHGIVTDWNDMERIWSYIYSKEQLATFTEDHPVLLTEAPLNPRRNREKAAEFFFEGINAPALFVS 140
            :||:|.||:.::.||.||: ...:....|:|.||:::.||:|..||||.||..||....||:.|:
Mouse   119 KHGVVVDWDCIQNIWEYIF-HTAMKIMPEEHAVLVSDPPLSPTSNREKYAELLFETFGIPAMHVT 182

  Fly   141 MQAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLKTLIRREGFNF 205
            .||:||:|:.|:.:|:|::||.||:|.|||.||..:|....|||.||.|:|.||..|:...|..|
Mouse   183 SQALLSIYSYGKTSGLVVESGHGVSHVVPISEGDLLPGLPSRVDYAGCDLTNYLMQLLNEAGHKF 247

  Fly   206 RSTAEFEIVRSIKEKVCYLATNPQKEETVETEKF--AYKLPDGKIFEIGPARFRAPEVLFRPDLL 268
             |.....|:..||:|.||.|..|::|.::..::.  .|:||||||..||..|||..|:||:|.|:
Mouse   248 -SDDHLHIIEHIKKKCCYAALLPEEEMSLGLDELHVDYELPDGKIITIGQERFRCSEMLFKPSLV 311

  Fly   269 GEECEGIHDVLMYSIEK-SDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKDLKIRIAA 332
            |....|:.::....:.: .....::.:..|::|.||.|:..||.:|...||......|.....||
Mouse   312 GCTQPGLPELTATCLARCQGTGFKEEMAANVLLCGGCTMLDGFPERFQRELSLLCPGDSPTVAAA 376

  Fly   333 PQERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHRK 374
            | ||..|.|.||||||||..|:::|:||.|:||.|..|::.|
Mouse   377 P-ERKTSVWTGGSILASLQAFQQLWVSKEEFEERGCAAIYSK 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp1	NP_524331.2	NBD_sugar-kinase_HSP70_actin	5..376	CDD:302596	142/367 (39%)
Arp1	NP_524331.2	ACTIN	9..376	CDD:214592	142/367 (39%)
Actl7b	NP_079547.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		ACTIN	52..418	CDD:214592	142/367 (39%)
		NBD_sugar-kinase_HSP70_actin	53..418	CDD:302596	142/367 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900