DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arp1 and Actl7a

DIOPT Version :9

Sequence 1:	NP_524331.2	Gene:	Arp1 / 41566	FlyBaseID:	FBgn0011745	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_033741.1	Gene:	Actl7a / 11470	MGIID:	1343051	Length:	440	Species:	Mus musculus

Alignment Length:	376	Identity:	139/376 - (36%)
Similarity:	212/376 - (56%)	Gaps:	15/376 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VNQPVVIDNGSGVIKAGFAGEHIPKCRFPNYIGRPKHVRVMAGALEGDIFVGPKAEEHRGLLSIR 72
            |.:.||:|.|:|..|.||||...|..:....:|:|.......|....:.|||.:.......|.:.
Mouse    73 VTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGHELFNPDIHLKLV 137

  Fly    73 YPMEHGIVTDWNDMERIWSYIYSKEQLATFTEDHPVLLTEAPLNPRRNREKAAEFFFEGINAPAL 137
            .|:.|||:.||:.::.||.|:: ::::....|:|.||:::.||:|..||||.||..||..|.||:
Mouse   138 NPLRHGIIVDWDTVQDIWEYLF-RQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAM 201

  Fly   138 FVSMQAVLSLYATGRVTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVTRYLKTLIRREG 202
            .::.|:.||:|:.||.:|:|::.|.||::.||||||:.:|....|:|.||.|:|.||..|:...|
Mouse   202 HIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMNLMNNSG 266

  Fly   203 FNFRSTAEFEIVRSIKEKVCYLATNPQKEETVET--EKFAYKLPDGKIFEIGPARFRAPEVLFRP 265
            .:| |.....||..||.:.|::|.:|.:|:.:..  .:..|.|||||...:|..||...|:.|:|
Mouse   267 KHF-SEDHLGIVEDIKTRCCFVALDPIEEKKIPAPEHEIHYTLPDGKEIRLGQERFLCSEMFFKP 330

  Fly   266 DLLGEECEGIHDVLMYSIEKSDMDLRKMLYQNIVLSGGSTLFKGFGDRLLSELKKHSAKDLKIRI 330
            .|:.....|:|...:..:.|.|:.|::.|..||:|.||||:.:||.:||..||......|
Mouse   331 SLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPND----- 390

  Fly   331 AAPQ-----ERLYSTWMGGSILASLDTFKKMWISKREYEEEGQKAVHRKTF 376
             .||     ||..:.|.||||||||..|:.:|:.:.||||.|...::|:.|
Mouse   391 -TPQVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arp1	NP_524331.2	NBD_sugar-kinase_HSP70_actin	5..376	CDD:302596	138/374 (37%)
Arp1	NP_524331.2	ACTIN	9..376	CDD:214592	137/373 (37%)
Actl7a	NP_033741.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		ACTL7A_N	6..70	CDD:293445
		Required for interaction with TES. /evidence=ECO:0000250	36..56
		NBD_sugar-kinase_HSP70_actin	72..440	CDD:302596	138/374 (37%)
		ACTIN	74..440	CDD:214592	137/373 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900