DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(fu) and Sufu

DIOPT Version :9

Sequence 1:	NP_536750.2	Gene:	Su(fu) / 41565	FlyBaseID:	FBgn0005355	Length:	468	Species:	Drosophila melanogaster
Sequence 2:	NP_056567.2	Gene:	Sufu / 24069	MGIID:	1345643	Length:	485	Species:	Mus musculus

Alignment Length:	514	Identity:	189/514 - (36%)
Similarity:	264/514 - (51%)	Gaps:	92/514 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEANLDKKPEVKP--------------------PPGLKAIIDHLGQVYPNQPNPLQVTTLLKYW 45
            |||.    :|.|.|                    ||||.||.....::||:||||||||.::|||
Mouse     1 MAEL----RPSVAPGPAAPPASGPSAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYW 61

  Fly    46 LGGQDPLDYISMYNYPGDVDRNVPPHWHYISFGLSDLHGDERVHLREEGVTRSGMGFELTFRLAK 110
            |||.|||||:|||...|....|:|.||||||||||||:||.|||........||.||||||||.:
Mouse    62 LGGPDPLDYVSMYRNMGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKR 126

  Fly   111 TEIELKQQIENPEKPQRPPTWPANLLQAIGRYCFQTGNGLCFGDNIPWRKSLDGSTTSKLQNLLV 175
            ...|           ..||||||.|:|.:.||.||:.|..|.||::.|...||.| .|::|::|:
Mouse   127 ETGE-----------SAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHSPLDNS-ESRIQHMLL 179

  Fly   176 AQDPQLGCIDTPTGTVDFCQIVGVFDDELEQASRWNGRGVLNFLRQDMQTGGDWLVTNMDRQMSV 240
            .:|||:..:.||.|.|.|.|||||..:||..|.:|||:|:|..||.....||.||:|:|.|..::
Mouse   180 TEDPQMQPVRTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETI 244

  Fly   241 FELFPETLLNLQDD-----LEKQGSDLAGVNADFTFRELKPTKEVKEEVDFQALSEKCANDENNR 300
            ||:.|    :||.:     :|..||:|:||:|...:.:|....|.:|:      |.........|
Mouse   245 FEIDP----HLQQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDEED------SRSICLGTQPR 299

  Fly   301 QLT--DTQMKRE----------EPSFPQSMSMSSNSL-HKSCPL--------DFQAQAPNCI--- 341
            :|:  ||:..||          :|..|...|...|.| |...|.        ...|..|:.:
Mouse   300 RLSGKDTEQIRETLRRGLEINSKPVLPPINSQRQNGLTHDRAPSRKDSLGSDSSTAIIPHELIRT 364

  Fly   342 -SLDGIEITLAPGVAKYLLLAIKDRIRHGRHFTFKA--QHLALTLVAESVTGSAVTVNEPYGVLG 403
             .|:.:.:.........:.|.::.|:.||||||:|:  ..:|:|.|:..|.|:..|...||...|
Mouse   365 RQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAHG 429

  Fly   404 YWIQVLIPDELVPRLMEDFRSAGLDEKCEPKE-RL--ELEWPDKNLK------LIIDQP 453
            .|:|:|:.:|.|.:::||     |::...|:| :|  |..||:|.||      ::.|.|
Mouse   430 PWLQILLTEEFVEKMLED-----LEDLTSPEEFKLPKEYSWPEKKLKVSILPDVVFDSP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(fu)	NP_536750.2	SUFU	52..236	CDD:282876	89/183 (49%)
Su(fu)	NP_536750.2	SUFU_C	250..450	CDD:289253	64/240 (27%)
Sufu	NP_056567.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		6/23 (26%)
		SUFU	68..240	CDD:282876	89/183 (49%)
		SUFU_C	254..474	CDD:289253	62/230 (27%)
		Disordered. /evidence=ECO:0000250\|UniProtKB:Q9UMX1	280..361		18/86 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849149
Domainoid	1	1.000	186	1.000	Domainoid score	I3357
eggNOG	1	0.900	-	-		E1_28KPA
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9262
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2620
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50174
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008274
OrthoInspector	1	1.000	-	-		oto94829
orthoMCL	1	0.900	-	-		OOG6_107720
Panther	1	1.100	-	-	LDO	PTHR10928
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5422
SonicParanoid	1	1.000	-	-		X6249
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790