DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001093657.1	Gene:	Cyp4f37 / 677156	MGIID:	3780112	Length:	546	Species:	Mus musculus

Alignment Length:	524	Identity:	140/524 - (26%)
Similarity:	225/524 - (42%)	Gaps:	113/524 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTWTL-------WCGLLFLLWIYFL---WSRRRFYLLTLKIPGP------LGYPILGMAHWLMRR 50
            |:|.|       |.....|.|.|..   .||.|.:      |.|      ||:  |||.......
Mouse    17 LSWHLLLLGAASWILARILAWTYSFCENCSRLRCF------PQPPKRNWFLGH--LGMIEHNEEG 73

  Fly    51 EDILNAFG-CFLDKHGPTIFSWLGP-IPFMIVSDPQVVQDIFTSPHCVNKGII-------YKAVD 106
            ..::...| .:.|.|    ..|||| ||.:.:.||     .|.:|..:...::       :..|.
Mouse    74 MQLMTEAGQTYRDVH----LCWLGPVIPVLRIVDP-----AFVAPLLLASALVAPKDTTFHTFVK 129

  Fly   107 DGAGVGLFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK--DLIPL 169
            ...|.|||.....:||.||:||.|||...:|..::.|||:...::..:.:.|..:|..  ::...
Mouse   130 PWLGDGLFLNSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEH 194

  Fly   170 LQSFTLGIATQTTMGSDVKDEES----------------FRSNSLL---------------GRYQ 203
            :...||....:...|.|...:||                .||:.|.               .|..
Mouse   195 ISLMTLDSLQKCLFGFDSNCQESPSEYISAILELSSLVIKRSHQLFLFVDFLYYHTADGRRFRKA 259

  Fly   204 C-ILETMTDMCFSPWLNSRFCRQLAGKESH--YYQAKTEIR--QFIRKIIERKLAEDEMGALPSI 263
            | ::...||...      |..|.....::|  :.::||:.:  .||..::   ||:||.|
Mouse   260 CDLVHNFTDAVI------RERRHTLSSQNHDEFLKSKTKSKTLDFIDVLL---LAKDEHG----- 310

  Fly   264 QSNDKNLFLNLVTDLMRRGVFTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEE 328
                |.|     :|         :::..|::..:||..:|||:|:.:.|..||..||||||..:|
Mouse   311 ----KEL-----SD---------EDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQE 357

  Fly   329 IKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAI 393
            ::.:.......::.:.|..|:.:|.:.:.||:|:.|||..:.|:.::|:.|.:|.|:|||....|
Mouse   358 VQELLRGREPQEIEWDDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDGRVIPKGNICVI 422

  Fly   394 DIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLL 458
            .|:.:|.:..:| ||.|.::|..|.|.|...:.|.|:|||:.|.|||||..:|:....|.||..|
Mouse   423 SIFGIHHNPSVW-PDPEVYDPFRFDPENAHKRPPLAFIPFSAGPRNCIGQTFAMNEMMVALALTL 486

  Fly   459 RNYR 462
            ..:|
Mouse   487 LRFR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	130/483 (27%)
Cyp4f37	NP_001093657.1	CYP4F	74..515	CDD:410772	123/459 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820