DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and zgc:123299

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_021324190.1	Gene:	zgc:123299 / 641477	ZFINID:	ZDB-GENE-051120-33	Length:	501	Species:	Danio rerio

Alignment Length:	521	Identity:	125/521 - (23%)
Similarity:	225/521 - (43%)	Gaps:	85/521 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WIYFLWSRRRFYLLTL--------------------KIPGP------LGY-PILGMAHWLMRRED 52
            ||:::    ..|||..                    .||||      ||: |.|..|   :..:|
Zfish     5 WIFYI----ILYLLAAVFTAFFAYCLYVHHIHQKYDHIPGPPRDNFLLGHSPSLTKA---LYSDD 62

  Fly    53 --ILNAFGCFLDKHGPTIFSWLGPIPF--MIVSDPQVVQDIFTSPHCVNKGIIYKAVDD-----G 108
              |.:.|..:.:|:||..  .:..:.:  ::|..|:..:.|..||.......:|:.|.:     .
Zfish    63 SLIYDLFLQWAEKYGPVY--RINTLHYVTIVVYCPEATKTIMMSPKYTKDPFVYRRVFNLFGKRF 125

  Fly   109 AGVGLFSLKD-PRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLI-PLLQ 171
            .|.||.:..| ..|...|::::|||....|.|.:..|:..:..|:|:||.:.::....:: .|:.
Zfish   126 LGYGLITAVDHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEIANNKTPAVMHDLVN 190

  Fly   172 SFTLGIATQTTMGSDVK---DEESFRSNSLLGRYQCILETMT----DMCFSPWLNSRFCRQLAGK 229
            ..||.:..:...|.|:.   .::|...|::    :..|:.||    |..|          ::..|
Zfish   191 CVTLDVICKVAFGVDLNFLTQKDSPFQNAV----ELCLKGMTFDVRDPLF----------RIIPK 241

  Fly   230 ESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVEDE-S 293
            .....|...|..:.:||..| |..::...|:.:.:...|::...::.....:.|.:.::.|.. .
Zfish   242 NWKLIQQVREATELLRKTGE-KWIQNRKTAVKNGEDVPKDILTQILKSAEEQNVTSTEDFEQMLD 305

  Fly   294 NIIVF--GAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLIL 356
            |.:.|  ...|||||.:.:.:|.|...||..:||..|:..:.....  ::|..|..::.||..:|
Zfish   306 NFVTFFMAGQETTANQLSFAIMELGRNPEIYKRAKAEVDEVLGTKR--EISNEDLGKLTYLSQVL 368

  Fly   357 NESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHN 421
            .|::|:.|..|..:|...:|: :.|||.:|.|..:..:.:...|.:|.: .|...|:|..|
Zfish   369 KETLRLYPTAPGTNRWLHEDM-IINGIKIPGGCSVMFNSFVSQRLEKFF-KDPLKFDPKRF---- 427

  Fly   422 IQDKHP---YAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMKLK 483
             .:..|   |.|.||..|.|.|||..::.:.|||.|||||:.:.| :..|.::....:..|::.|
Zfish   428 -DENAPKPYYTYYPFALGPRTCIGQVFSQMEAKVVLAKLLQRFEF-SLVPGQSFDIKDTGTLRPK 490

  Fly   484 S 484
            |
Zfish   491 S 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	115/462 (25%)
zgc:123299	XP_021324190.1	p450	39..495	CDD:306555	119/483 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910