DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006524820.1	Gene:	Cyp4f40 / 631304	MGIID:	3645508	Length:	551	Species:	Mus musculus

Alignment Length:	511	Identity:	137/511 - (26%)
Similarity:	223/511 - (43%)	Gaps:	83/511 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WCG---------LLFLLWIYFLWSRRRF----YLLTLKIPGPLGYPILGMAHWLMRREDILNAFG 58
            |.|         |||.| :...|...||    |.|..|.....|:|.....:|          |.
Mouse    35 WLGLGPMSASPWLLFFL-VGISWFLARFLTQLYTLYAKCQRLCGFPQPPKKNW----------FW 88

  Fly    59 CFLDKHGPT-----------------IFSWLGPI-PFMIVSDPQVVQDIFTSPHCV--NKGIIYK 103
            ..|....||                 ..:||||| |.:.:..|.:::.:.::...|  ...|.|.
Mouse    89 GHLGMSPPTEEGMKQVTELVTTYPQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDDIFYS 153

  Fly   104 AVDDGAGVGLFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIP 168
            .:....|.||......:|:.||::|.|||...:|..::.|||..|.::..:...|...|...| .
Mouse   154 FLKPWLGDGLLVSAGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSTRL-N 217

  Fly   169 LLQSFTLGIATQTTMGSDVKDEESFRSNSLLGRYQ---CILETMT-------------DMCFSPW 217
            :.::.:|     .|:.:..|...||.||......|   .|||..|             |:.:
Mouse   218 MFENISL-----MTLDTLQKCVFSFNSNCQEKPSQYIAAILELSTLAVKRNEQLLMHVDLLY--- 274

  Fly   218 LNSRFCRQLAGKESHYYQAKTEIRQFIRKII-ERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRR 281
                   :|......:|:|...:..|...:| ||:....:.|....|::..|:..|:.:..|:..
Mouse   275 -------RLTPDGMRFYKACRLVHDFTDAVIQERRRTLLKHGGDDIIKAKAKSKTLDFIDVLLLT 332

  Fly   282 GVFTLKNVED-----ESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDV 341
            .....|.:.|     |::..:|...:|||:.:.:.|..||..||:|||..:|::.:..:....::
Mouse   333 KDEDGKELSDEDIRAEADTFMFRGHDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEI 397

  Fly   342 SYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWG 406
            .:.|..|:.:|.:.:.||:|:.|||.:|||..:||:.|.:|.::||||...|:|:..|.:..:|
Mouse   398 EWDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRIIPKGVICIINIFGTHHNPTVW- 461

  Fly   407 PDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYR 462
            .|.|.::|..|.|.|||.:.|.::|||:.|.|||||..:|:...||.||..|..:|
Mouse   462 RDPEVYDPFRFDPENIQARSPLSFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	125/472 (26%)
Cyp4f40	XP_006524820.1	p450	79..542	CDD:365848	124/466 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810