Protein Alignment Cyp313a4 and Cyp3a25

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_062766.2
• Gene: Cyp3a25 / 56388
• MGIID: 1930638
• Length: 503
• Species: Mus musculus
• Alignment Length: 533
• Identity: 140/533 - (26%)
• Similarity: 240/533 - (45%)
• Gaps: 99/533 - (18%)

  Fly     3 TWTLWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRREDILNAF--------GC 59
            ||.|....|.|.:||..:|...|  ..|.||||...|:||         .|.|.:        .|
Mouse    11 TWVLLVTSLVLFYIYGTYSHGLF--KKLGIPGPKPLPLLG---------TIFNYYDGMWKFDEDC 64

  Fly    60 FLDKHGPTIFSWLGPIPFMIVSDPQVVQ--------DIFTSPHCVNK-GIIYKAVDDGAGVGLFS 115
            : .|:|.....:.||.|.:.:.||::::        .:||:...... |.:.||:...
Mouse    65 Y-KKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVGFMKKAITIS------- 121

  Fly   116 LKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGE----KDLIPLLQSFTLG 176
             :|..|...|.||:|.|....|....||..:...:|:..|...::.||    ||   :..::::.
Mouse   122 -EDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKD---IFGAYSMD 182

  Fly   177 IATQTTMGSDV----KDEESF--RSNSLLGRYQCILETMTDMCFSPWLN--------SRFCRQLA 227
            :.|.|:.|.:|    ..::.|  ::..:| :::.....:..:...|:|.        |.|.|
Mouse   183 VITGTSFGVNVDSLNNPQDPFVQKAKKIL-KFKIFDPFLLSIILFPFLTPIYEMLNFSIFPR--- 243

  Fly   228 GKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNL--FLNLVTDLMR-RGVFTLKNV 289
                       :...|.:|.::|...|       .:.||.||.  ||.|:.:... :|..:.|.:
Mouse   244 -----------DSMNFFKKFVKRMKKE-------RLASNQKNRVDFLQLMMNTQNSKGQESQKAL 290

  Fly   290 ED-----ESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQM 349
            .|     ::.|.:||.::.|:.::...:..||..|:.|::..:||....||..  .|:|.....|
Mouse   291 SDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKA--PVTYDALMDM 353

  Fly   350 VYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNP 414
            .|||:::|||:|:.|....:.|.:.:|::: ||:.:|||..:.|.||.:||:.:.| |:.:.|.|
Mouse   354 EYLDMVVNESLRLYPIAIRLERVSKKDVEI-NGVFIPKGTVVMIPIYPLHRNPEYW-PEPQEFCP 416

  Fly   415 DHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDIT 479
            :.|...|..:..||.|:||..|.|||||.|:||||.|:.:..:|:|:   |..|.|.    ..|.
Mouse   417 ERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNF---TVQPCEE----TQIP 474

  Fly   480 MKLKSVPLLELQK 492
            :|:...|:.:.:|
Mouse   475 LKISREPIFQPEK 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	118/458 (26%)
Cyp3a25	NP_062766.2	CYP3A	67..492	CDD:410743	120/465 (26%)