DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a4 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	128/474 - (27%)
Similarity:	214/474 - (45%)	Gaps:	30/474 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRR-------EDILNAFGCFLDKH 64
            |.....|..||..:  |.|..|.       |:|.....:|||..       |..|......:..:
  Rat    29 WILAQILTQIYAAY--RNFRRLR-------GFPQPPKRNWLMGHVGMVTPTEQGLKELTRLVGTY 84

  Fly    65 GPTIFSWLGP-IPFMIVSDPQVVQDIFTSPHCV--NKGIIYKAVDDGAGVGLFSLKDPRWSIHRK 126
            ......|:|| :|.:.:....:|:.|..:...|  ...|.|..:....|.||......:||.||:
  Rat    85 PQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYTILKPWLGDGLLVSAGDKWSRHRR 149

  Fly   127 LLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK--DLIPLLQSFTLGIATQTTMGSDVKD 189
            :|.|||...:|..::.|||..|.::..:.:.|..:|..  |:...:...||....:.....|...
  Rat   150 MLTPAFHFNILKPYVKIFNDSTNIMHAKWKRLISEGSSRLDMFEHVSLMTLDSLQKCVFSFDSNC 214

  Fly   190 EESFRSNSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAKTEIRQFIRKII-ERKLA 253
            :|  :|:..:.....:...:......|.|.......|......:::|...:.:|...:| ||:..
  Rat   215 QE--KSSEYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHKACNLVHEFTDAVIRERRRT 277

  Fly   254 EDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVED-----ESNIIVFGAFETTANAVYYTLM 313
            ..:.|....::|..|:..|:.:..|:.......|.:.|     |::..:|...:|||:.:.:.|.
  Rat   278 LPDQGLDEFLKSKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILY 342

  Fly   314 LLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLK 378
            .||..||||||..:|::.:..:....::.:.|..|:.:|.:.:.||:|:.|||.|:||..:||:.
  Rat   343 NLAKHPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDIL 407

  Fly   379 LSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGW 443
            |.:|..:|||:...|.|:.:|.:..:| ||.|.:||..|.|.||:|..|.|:|||:.|.|||||.
  Rat   408 LPDGRTIPKGIICLISIFGIHHNPSVW-PDPEVYNPFRFDPENIKDSSPLAFIPFSAGPRNCIGQ 471

  Fly   444 RYALISAKVTLAKLLRNYR 462
            .:|:...||.||..|..:|
  Rat   472 TFAMSEMKVALALTLLRFR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	121/448 (27%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	115/420 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810