DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	513	Identity:	140/513 - (27%)
Similarity:	255/513 - (49%)	Gaps:	41/513 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GLLFLLWIYFL---------------WSRRRFYLLTLKIPGPLG-YPILGMA-HWLMRREDILNA 56
            |:||...:..|               |:..|      .|||..| |||:|.| .:.....|..|.
Zfish    11 GILFTAVLLLLLASTAYNPLKNYIGKWNEMR------PIPGMAGAYPIIGNALQFKTNAGDFFNQ 69

  Fly    57 F--GCFLDKHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDP 119
            .  |...::|.|....|:||:||:|:...:.::.:.::...::|...|:.:....|.||.:....
Zfish    70 IIEGTNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTSTGE 134

  Fly   120 RWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMG 184
            :|...||:|.|.|...:|..||.:.|.:|.:|:.:::.|:|....:....:....|.|..:|.||
Zfish   135 KWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCFNFITLCALDIICETAMG 199

  Fly   185 SDVKDEESFRSNSLLGRYQCILETMTDMCFSPWL--NSRFCRQLAGKESHYYQAKTEIRQFIRKI 247
            ..:..:.:..|..:...|: :.:.:|....:|||  :..:.:...||| |..:.|. :..|...:
Zfish   200 KKIYAQSNADSEYVQSVYK-MSDIITKRQRAPWLWPDWIYNKLKEGKE-HAKRLKI-LHSFTANV 261

  Fly   248 IERKLAEDEMGALPSIQSND----KNLFLNLV--TDLMRRGVFTLKNVEDESNIIVFGAFETTAN 306
            | |:.|| .|.:.|...|:.    :..||:::  |........:.:::::|.:..:|...:|||.
Zfish   262 I-RERAE-FMSSEPDSDSDQGERKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFMFEGHDTTAA 324

  Fly   307 AVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSR 371
            ::.:.|.|:...||.|:....|::.:| .:.:..|...|.:::.||:.::.||:|:.|.||:.:|
Zfish   325 SMNWALHLIGSHPEVQKAVQAELQEVF-GSSERHVGVEDLKKLRYLECVIKESLRIFPSVPLFAR 388

  Fly   372 QTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKG 436
            ...:...: ||..|||||...|..|.:||..:.: |:.|.|.|:.|:|.|.:.:||||||||:.|
Zfish   389 SICEACHI-NGFKVPKGVNAVIIPYALHRDPRYF-PEPEEFQPERFMPENSKGRHPYAYIPFSAG 451

  Fly   437 IRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMKLKSVPLLELQKRT 494
            .|||||.|:|::..||.||.:||::..:.....|.|..:.::.::.:....::||:|:
Zfish   452 PRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELRPLGELILRPEKGIWIKLQRRS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	128/443 (29%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	130/468 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910