DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	496	Identity:	134/496 - (27%)
Similarity:	244/496 - (49%)	Gaps:	22/496 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLWIYFLWSRRRFYLLTLK----IPGPLG--YPILGMAHWLMRRED-ILNAFGCFLD-KHGPTIF 69
            :.:.|..:...:.||...|    ||| :|  :|.:|.|.......| .|...|...: ::.|.:.
Zfish    20 ICFAYITYQLLKSYLHKWKELKPIPG-IGNTFPFIGNALQFKSNGDFFLQLVGYTTEFQNSPLLK 83

  Fly    70 SWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHRKLLNPAFGH 134
            .|:|||||:|:...:.|:.:..:|..::|...|:.:....|.||.:....:|...||:|.|.|..
Zfish    84 IWIGPIPFLILFHAETVETVLNNPVHIDKAYAYQFLHPWLGTGLLTSTGDKWRRRRKMLTPTFHF 148

  Fly   135 KVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVKDEESFRSNSLL 199
            .:|..||.:.|.:..:|:::||.....|..:....:....|.|..:|.||..:..:.::.|..:.
Zfish   149 SILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSHITLCALDIICETAMGKRIYAQSNYDSEYVR 213

  Fly   200 GRYQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQ 264
            ..|: :.:.:|.....||....|.....|:...:.::...:..|...:|..:  .:.:..:.|..
Zfish   214 TVYR-MSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTESVINER--AEYLSYVESDS 275

  Fly   265 SNDKNL-----FLNLVTDLMRRG--VFTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQ 322
            .:|:.:     ||:::.......  :.|.|::::|.:..:|...:|||.|:.:.:.||...||.|
Zfish   276 ESDQGMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQ 340

  Fly   323 ERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPK 387
            .:|.:|:..:| ...:..|:..|.:::.||:.::.||:|:.|.||..:|....|.:: ||..|||
Zfish   341 RKAQQELFEVF-GESERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQI-NGFKVPK 403

  Fly   388 GVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKV 452
            |..|.:..|.:||..:.: ||.|.|.|:.|||.|...:||||||||:.|:|||||.|:|::..||
Zfish   404 GTNIVVITYALHRDPRFF-PDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKV 467

  Fly   453 TLAKLLRNYRFKTSFPFENLYFVEDITMKLKSVPLLELQKR 493
            .||.:||.:........|.|..:.::.::.:....:.|::|
Zfish   468 ILAYILRYFNIVACQKREELRPLGELVLRPEQGIWITLERR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	125/442 (28%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	127/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810