Protein Alignment Cyp313a4 and Cyp3a41a

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_059092.2
• Gene: Cyp3a41a / 53973
• MGIID: 1858451
• Length: 504
• Species: Mus musculus
• Alignment Length: 540
• Identity: 136/540 - (25%)
• Similarity: 240/540 - (44%)
• Gaps: 112/540 - (20%)

  Fly     3 TWTLWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRREDILNAF--------GC 59
            ||.|...:|.||:.|  .:|.........||||...|.||         .:||.:        .|
Mouse    11 TWVLLAIILVLLYRY--GTRTHGLFKKQGIPGPKPLPFLG---------TVLNYYKGLWKFDMEC 64

  Fly    60 FLDKHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHC----VNK------GIIYKAVDDGAGVGLF 114
            : :|:|.|...:.|.:|..:::||::::::... .|    .|:      ||:.||:...
Mouse    65 Y-EKYGKTWGLFDGQMPLFVITDPEMIKNVLVK-ECFSVFTNRREFGPVGIMSKAISIS------ 121

  Fly   115 SLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGE----KDLIPLLQSFTL 175
              ||..|..:|.||:|.|....|....|:..:...:|:..|....:.|:    ||   :|.::::
Mouse   122 --KDEEWKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEAEKGKPVTMKD---VLGAYSI 181

  Fly   176 GIATQTTMGSDV----KDEESFRSNS----------------LLGRYQCILETMTDMCFSPWLNS 220
            .:.|.|:.|.:|    ..|:.|...:                :|..:...:..|.::|..|
Mouse   182 DVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEMLNICMFP---- 242

  Fly   221 RFCRQLAGKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQ--------SNDKNLFLNLVTD 277
                    |:|..:     .::|:.::.|.:|...:...:..:|        |.||:.. ..::|
Mouse   243 --------KDSIEF-----FKKFVNRMKESRLDSKQKHRVDFLQLMMNAHNNSKDKDSH-KALSD 293

  Fly   278 LMRRGVFTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVS 342
            :         .:..:|.:.:|..:|||::.:.:||..||..|:.|::..|||....||..  ..:
Mouse   294 M---------EITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNKA--PPT 347

  Fly   343 YADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGP 407
            |....:|.|||::|||::|:.|....:.|...:|::| ||:.:|||..:.|..|.:|...:.| |
Mouse   348 YDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVEL-NGVYIPKGSTVMIPSYALHHDPQHW-P 410

  Fly   408 DAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENL 472
            :.|.|.|:.|...|.....||.|:||..|.|||||.|:|.::.|:.|.|:::|:.|:   |.:.
Mouse   411 EPEEFQPERFSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQ---PCQE- 471

  Fly   473 YFVEDITMKLKSVPLLELQK 492
               ..|.:||....||:.:|
Mouse   472 ---TQIPLKLSRQGLLQPEK 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	115/465 (25%)
Cyp3a41a	NP_059092.2	CYP3A	67..493	CDD:410743	118/472 (25%)