DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	134/525 - (25%)
Similarity:	233/525 - (44%)	Gaps:	84/525 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GLLFLL------WIYFLWSRRRFYLLTLKIPGPLGYPILGMAHWLMRR------EDILNAFGCFL 61
            |||.||      ::...|..:.|.    :.|.|   |.    ||....      :::.....|.
  Rat    26 GLLLLLVKAVQFYLQRQWLLKAFQ----QFPSP---PF----HWFFGHKQFQGDKELQQIMTCV- 78

  Fly    62 DKHGPTIF-SWL-GPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIH 124
             ::.|:.| .|. |...::||.||..::.|.........| :|:.:....|.||..|....|..|
  Rat    79 -ENFPSAFPRWFWGSKAYLIVYDPDYMKVILGRSDPKANG-VYRLLAPWIGYGLLLLNGQPWFQH 141

  Fly   125 RKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVKD 189
            |::|.|||.:.:|..::........|:||:.|.|.  |:...|.:.|..:|       |..|...
  Rat   142 RRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLA--GQDSSIEIFQHISL-------MTLDTVM 197

  Fly   190 EESFRSNSLL---GRYQCILETMTDMCFSPWLNSRF---CRQLAGKESHYYQAKTEIRQFIRK-- 246
            :.:|..|..:   |.|:..::.:.:      ||..|   .|.:..:....|...:....|.|.
  Rat   198 KCAFSHNGSVQVDGNYKSYIQAIGN------LNDLFHSRVRNIFHQNDTIYNFSSNGHLFNRACQ 256

  Fly   247 --------IIERKLAEDEM---GALPSIQSNDKNLFLN-LVTDLMRRG-VFTLKNVEDESNIIVF 298
                    :|  ||.:|::   |.|..::...:..||: |:...|..| ..:.|::..|.:..:|
  Rat   257 LAHDHTDGVI--KLRKDQLQNAGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVDTFMF 319

  Fly   299 GAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGD-FDVSYADTQQMVYLDLILNESMRV 362
            ...:|||:.|.:....||..||:|:|..||::::.   || ..:::....|:.|..:.:.|::|:
  Rat   320 EGHDTTASGVSWIFYALATHPEHQQRCREEVQSVL---GDGSSITWDHLDQIPYTTMCIKEALRL 381

  Fly   363 IPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHP 427
            .||||.:.|:.|..:...:|..:|||:|:.:.||.:|.:.|:| |:.|.|:|..|.|.:  .:|.
  Rat   382 YPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVW-PNPEVFDPSRFAPDS--PRHS 443

  Fly   428 YAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRF-----KTSFPFENLYFVEDITMKLKSVPL 487
            ::::||:.|.|||||.::|:...||.:|..|..:..     |...|...|      .:|.|:...
  Rat   444 HSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTKVPIPLPRL------VLKSKNGIY 502

  Fly   488 LELQK 492
            |.|:|
  Rat   503 LYLKK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	119/466 (26%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	124/489 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910