DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a4 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	147/502 - (29%)
Similarity:	247/502 - (49%)	Gaps:	43/502 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLFLLWIYFLWSRRRFYLLTL--KIPGPLGYPILGMA-HWLMRREDILNAFGCFLDKHGPTI--- 68
            |:||:    ::::||..|:..  |||||...|.||.| ...:..:::.|.........|..|
  Fly    38 LIFLV----VYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIGMQKLWGTRIGIN 98

  Fly    69 FSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHRKLLNPAFG 133
            ..|.|..|.:::.:|:.|:.|..|...|||...|..:....|.||.:..|.:|...||:|.|||.
  Fly    99 RVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFH 163

  Fly   134 HKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDV---KDEESFRS 195
            .|:|..|:.:||.::|:|..:|.........:|.|.:...||.|..:|.||..:   .:.||...
  Fly   164 FKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYV 228

  Fly   196 NSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAKTEIRQFIRKIIERKLAEDEMGAL 260
            .::.|....:......:    ||.|.|...|..:...:......:..|...:|..:.||     |
  Fly   229 KAVYGIGSIVQSRQAKI----WLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAE-----L 284

  Fly   261 PSIQSNDKN------------------LFLNLVTDLMRRG-VFTLKNVEDESNIIVFGAFETTAN 306
            ..:|.|:.|                  .||:|:.|..:.| |.:.:::.:|.:..:|...:||:.
  Fly   285 AILQENNNNNNNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDTFMFEGHDTTSA 349

  Fly   307 AVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSR 371
            |:.:||.||...||||||..||:.:||.:..:...:..:...|.||:..:.:|:|:.|.||:::|
  Fly   350 AISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMAR 414

  Fly   372 QTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKG 436
            ...:|:.: .|.:||.|.|..|..|.:||:.::: |..|.||||:|||.|...:||:|||||:.|
  Fly   415 MVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVF-PKPEQFNPDNFLPENCAGRHPFAYIPFSAG 477

  Fly   437 IRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMKLK 483
            .|||||.::|::..|..::.:||.|:.:.....|:|..:.::.::.|
  Fly   478 PRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	136/457 (30%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	139/477 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8399
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.860