DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp313a3

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_650170.2	Gene:	Cyp313a3 / 41488	FlyBaseID:	FBgn0038007	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	220/497 - (44%)
Similarity:	327/497 - (65%)	Gaps:	8/497 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTWTLWCGLLFLLWIYFLWSRRRFYLLTLKIPGPLGYPILGMA-HWLMRREDILNAFGCFLDKH 64
            |.|:.|...:....||||||||||.|::..|||||:|.||||:| .:|:..:..::....::|.:
  Fly     1 MDTFQLLLAVGVCFWIYFLWSRRRLYMMHFKIPGPMGLPILGIAFEYLITYKRKMSIRTKYMDIY 65

  Fly    65 GPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIY-KAVDDGAGVGLFSLKDPRWSIHRKLL 128
            |.|...|:||.||:|..||::.::||.||.|:|:..|: |.|:...|.||.||:..:|...||.|
  Fly    66 GSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSKPVNSCTGDGLLSLEASKWVDRRKNL 130

  Fly   129 NPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVKDEESF 193
            ||||...||||||||||.|...|:..|:.|...|||.:...:..::..||||||:|:|||.:.||
  Fly   131 NPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIVRWSFRIATQTTVGTDVKKDASF 195

  Fly   194 RSNSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHYYQAKTEIRQFIRKIIERKL-AEDEM 257
            :::|:|..|:..::.:......|:.:::....|.|.|:....||:.:.:.|..|:::|| .:.|.
  Fly   196 KNDSVLKSYETFMKIIVMNVLLPFTHNKIFSTLGGFETQKALAKSNVNKMIGTIVDKKLMTKPES 260

  Fly   258 GALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQ 322
            |:.|.|.|     .:|...:|.|.|..:.:.|:.|....|..|||||.:.||:.|:|||||||:|
  Fly   261 GSQPEITS-----VINKAIELHRNGEMSREEVQSECCSFVVAAFETTGDTVYHALILLAMFPEHQ 320

  Fly   323 ERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPK 387
            :..::|:|.:||..|||:|:|.|.|:||:|:.::||::|:||.||...|:|.:|.:||:|:|:||
  Fly   321 DTVYQELKELFPVAGDFEVTYDDLQRMVFLERVVNETLRLIPSVPFTPRETIRDFRLSSGVVIPK 385

  Fly   388 GVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKV 452
            ||.|.|||:..||::..||.|..:||||||||.|::|:||||||||:||.||||||:|.|:|:|:
  Fly   386 GVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRHPYAYIPFSKGRRNCIGWKYGLMSSKL 450

  Fly   453 TLAKLLRNYRFKTSFPFENLYFVEDITMKLKSVPLLELQKRT 494
            .|:|:|||.:..|||.:|:|.||::|.|:|...|.||..:||
  Fly   451 ALSKILRNCKVSTSFRYEDLEFVDNIGMELAQSPGLEFHRRT 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	189/434 (44%)
Cyp313a3	NP_650170.2	p450	33..463	CDD:299894	189/434 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450076
Domainoid	1	1.000	169	1.000	Domainoid score	I1170
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D28972at7147
OrthoFinder	1	1.000	-	-		FOG0008559
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900