DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and CYP4F3

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens

Alignment Length:	504	Identity:	131/504 - (25%)
Similarity:	220/504 - (43%)	Gaps:	78/504 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTWTLWCGLLFLLWIYFLWS---RRRFYLLTLKIPGP------LGYPILGMAH----WLMRRED 52
            :|....|.....|.|.|..:.   |.|.:      |.|      ||:  ||:.|    .|:..:.
Human    23 LLVGASWLLARILAWTYTFYDNCCRLRCF------PQPPKRNWFLGH--LGLIHSSEEGLLYTQS 79

  Fly    53 ILNAFG---CFLDKHGPTIFSWLGPIPFMI-VSDPQVVQDIFTSPHCV--NKGIIYKAVDDGAGV 111
            :...||   |:          |:||...:: :..|..::.:..:|..:  ...:.|..:....|.
Human    80 LACTFGDMCCW----------WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGD 134

  Fly   112 GLFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK--DLIPLLQSFT 174
            ||......:||.||::|.|||...:|..::.|||....::..:.:.|..:|..  |:...:...|
Human   135 GLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMT 199

  Fly   175 LGIATQTTMGSDVKDEES--------FRSNSLL-GRYQCILETMTDMCFSPWLNSRFCRQLAGKE 230
            |....:.....|...:|.        ...::|: .|:|.||           |...|...|....
Human   200 LDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQIL-----------LYIDFLYYLTPDG 253

  Fly   231 SHYYQAKTEIRQFIRKII-ERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVED--- 291
            ..:.:|...:..|...:| ||:......|....:|:..|:..|:.:      .|..|...||
Human   254 QRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFI------DVLLLSKDEDGKK 312

  Fly   292 --------ESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQ 348
                    |::..:|...:|||:.:.:.|..||..||||||..:|::.:..:....::.:.|..|
Human   313 LSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQ 377

  Fly   349 MVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFN 413
            :.:|.:.:.||:|:.||||.|||..:||:.|.:|.|:|||:...|.::..|.:..:| ||.|.::
Human   378 LPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-PDPEVYD 441

  Fly   414 PDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYR 462
            |..|.|.||:::.|.|:|||:.|.|||||..:|:...||.|...|..:|
Human   442 PFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	124/469 (26%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	124/469 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810