DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a4 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	136/523 - (26%)
Similarity:	247/523 - (47%)	Gaps:	60/523 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WCG---LLFLLWIYFLW---SRRRFYLLTLKIPGPLGYPILGMAHW---------LMRREDILNA 56
            |.|   ||..|.:|.|:   .:.|...||.|.|.|...|.:|..|.         |.|..:::|.
  Fly     3 WLGFGLLLLALSLYLLYVFERQSRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMINE 67

  Fly    57 FGCFLDKHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRW 121
               .|..|...:  |:|...:::..:|:.:|.:.::...:.|...|:..::....|||:....:|
  Fly    68 ---HLHDHRAKL--WMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKW 127

  Fly   122 SIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK-DLIPLLQSFTLGIATQTTMGS 185
            |..||::.|||.:.::..|:.:|.:::.:||..:....:.|:: |.:.|:..|||....:|.:|.
  Fly   128 SHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGV 192

  Fly   186 DVKDEESFRSNSLLGRYQCILETMTDMCFSPWLNSRFCRQ--LAGKESHYYQAKTEIRQ---FIR 245
            .|..:.|.:| ..|...:.||     :.....|.:.|.|.  :..:.|||.:.:..|:.   |..
  Fly   193 SVGSQSSAKS-EYLDAVKSIL-----VIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTE 251

  Fly   246 KIIERKLAEDEMGA-LPSIQSNDKNL--------FLNLVTDLMRRG----VFTLKNVEDESNIIV 297
            .||::::.|....| ..:.||:|..|        ||:  |.|:.:|    ..|:|::.:|.:.|:
  Fly   252 GIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLD--TLLLSKGPDGKPLTVKDIREEVDTII 314

  Fly   298 FGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRV 362
            ||.|:.||..:.:.:..:.:.||:|:|..||:.::........:|....:|:.:|:..:.|::|:
  Fly   315 FGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRM 379

  Fly   363 IPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHP 427
            .|..|:.:|:.:.:..: |...:|||..:.|...:|.|.|..: ||...|.||.:..........
  Fly   380 YPSGPLTARKATANCTI-NDFFIPKGSDVIISPIYMGRCKDFF-PDPMVFKPDRWAIGAEPKIEA 442

  Fly   428 YAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRF----------KTSFPFENLYFVEDITMKL 482
            ..:|||..|.|:|:|.|||::..|:.||.||||:.|          |.:|.. .|:.||....:.
  Fly   443 TTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVI-TLHTVEPYLCRA 506

  Fly   483 KSV 485
            |::
  Fly   507 KNL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	119/469 (25%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	124/485 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870