DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4p2

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	131/532 - (24%)
Similarity:	249/532 - (46%)	Gaps:	54/532 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTWTLWCGLLFLLWIYFLWSRRRFY----LLTLKIPGPLGYPILGMAHWLMRREDILNAFGCFL 61
            |:...||..:..|:.|::::...:.|    ....::....|.|:..:...:..|....|.|. .|
  Fly     1 MMICLLWISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFD-LL 64

  Fly    62 DKHGPTIFSWL----------------GPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAG 110
            .|....:|:.|                |...|.:: |.....:|...|:.:.||:||..:.....
  Fly    65 GKDTDQVFTHLRQLAKNSGDSYLQYSMGFSNFNVI-DAHNAANILNHPNLITKGVIYNFLHPFLR 128

  Fly   111 VGLFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQS--- 172
            .|:.:..:.:|...|.:|...|...:|..|..||..|:...:.|.:     |:.:::..|:.
  Fly   129 TGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAESLKFVSQFQ-----GQNEVVVSLKDRIS 188

  Fly   173 -FTLGIATQTTMGSDVKDEESFRSNSLLGRYQCILETMTDMCFSP--WLNSRFCRQLAGKESHYY 234
             |||....:|.||..: ||.:.:.:.....:..|.|.:|....:|  |.:..: ....|   |.|
  Fly   189 RFTLNSICETAMGIKL-DEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVY-NMFTG---HKY 248

  Fly   235 QAKTE-IRQFIRKII--ERKLAEDEMGALPSIQSNDKNL---------FLNLVTDLMRRGVFTLK 287
            .|..: :.:|.|:||  .|.|.|:|:....:.|:.|.::         .|:.:....:.|:....
  Fly   249 NAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKDGLIDDI 313

  Fly   288 NVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKT-IFPNTGDFDVSYADTQQMVY 351
            .:.:|.:.::...::||:..:.:.||.::::...||..::||:. |..:..:.::|  ...::.|
  Fly   314 GISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLS--QLSKLNY 376

  Fly   352 LDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDH 416
            |...:.|:||:.|.:|::.|||.|:.:|.||:::||..||.|.::.:||:.|.| ...|.|.|:.
  Fly   377 LGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYW-ESPEEFRPER 440

  Fly   417 FLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMK 481
            |||.|...:||||||||:.|.|||||.:||:...|..:..:|::::.......:::.|...||::
  Fly   441 FLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQVGITLR 505

  Fly   482 LKSVPLLELQKR 493
            .|:...::|.:|
  Fly   506 FKNKIKVKLVRR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	119/466 (26%)
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	118/464 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960