DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	132/524 - (25%)
Similarity:	242/524 - (46%)	Gaps:	65/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LWCGLLFLLWIYF-------------LWSRRRFYLLTLKIPGPLGYPILGMAHWLMRR-EDILNA 56
            :|    |:|:|:.             .:.|||   :..|..||.|.|::|.||.:.:. .:||:.
  Fly     1 MW----FVLYIFLALPLLLVAYLELSTFRRRR---VLNKFNGPRGLPLMGNAHQMGKNPSEILDT 58

  Fly    57 FGCFLDKHGPTIF-SWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPR 120
            ...:..::|...| .|:|....::|:..:.::.|.:|...:.|..||:......|:||.:....:
  Fly    59 VFSWWHQYGKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSK 123

  Fly   121 WSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPL-QDDGEKDLIPLLQSFTLGIATQTTMG 184
            |..|||::.|||...:|..|..:.|..:...:..|:.: ..|...|........||.:...|.||
  Fly   124 WHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMG 188

  Fly   185 SDVKDEESFRSNSLLGRYQCILETMTDMC-------FSPWLNSRFCRQLAGKESHYYQAKTEIRQ 242
            ..:        |::..|...|::...|||       |.|...:....:||.....|.:....::.
  Fly   189 VSI--------NAMENRSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQD 245

  Fly   243 FIRKIIERKLAEDEMGALPSIQSND-----KNLFLN-LVTDLMRRGVFTLKNVEDESNIIVFGAF 301
            |..:||.:::...:.||: |..:.|     |..||: |::..:.......|.:.:|.:..:|...
  Fly   246 FTNEIIAKRIEAHKSGAV-STNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEEVSTFMFEGH 309

  Fly   302 ETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTG-DFDVSYADTQQMVYLDLILNESMRVIPP 365
            :||.:.|.:.:.||:...:.|.:.|:|.:.:..|:. ..|.::.:..||.||||.:.|:.||.|.
  Fly   310 DTTTSGVSFAVYLLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPS 374

  Fly   366 VPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAY 430
            ||.:.|.|.:|..: :|.:||||..:.:.:..:..::|:: .|...|.|:.|   .::...|:.|
  Fly   375 VPFIGRFTEKDYVI-DGDLVPKGTTLNLGLVMLGYNEKVF-KDPHKFRPERF---ELEKPGPFEY 434

  Fly   431 IPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMK------LKSVPLLE 489
            :||:.|.|||||.::||:..|..::|::||        ||.|..::::..|      ...:|..|
  Fly   435 VPFSAGPRNCIGQKFALLEIKTVVSKIIRN--------FEVLPALDELVSKDGYISTTIGLPDAE 491

  Fly   490 LQKR 493
            .:||
  Fly   492 RKKR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	116/448 (26%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	118/455 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860