DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4g1

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_525031.1	Gene:	Cyp4g1 / 30986	FlyBaseID:	FBgn0010019	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	150/545 - (27%)
Similarity:	256/545 - (46%)	Gaps:	73/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTWTLWCGLLFLLWIYFLWSRR-RFYLLTLKIPGPLGYPILGMAH---WLMRREDILNAFGCFL 61
            ||| || .|.|..:.:|..|.|. |.|.:...||.|...||||.||   .|...|.:....| :|
  Fly    27 MLT-TL-VGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLG-YL 88

  Fly    62 DKHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHRK 126
            :|:|.|:.:|||.:..:.:::|..::.|.:....:.|...|:......|.||.......|..|||
  Fly    89 NKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRK 153

  Fly   127 LLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVKDE- 190
            ::.|.|...:|.||:|.|...:..::.:: .|:.....|:...:...|:.|...|.||.....|
  Fly   154 MIAPTFHQSILKSFVPTFVDHSKAVVARM-GLEAGKSFDVHDYMSQTTVDILLSTAMGVKKLPEG 217

  Fly   191 -ESFRSNSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHY--------------------- 233
             :||.          ..:.:.|||  ..::.|..:.|...:|.|
  Fly   218 NKSFE----------YAQAVVDMC--DIIHKRQVKLLYRLDSIYKFTKLREKGDRMMNIILGMTS 270

  Fly   234 ---YQAKTEIRQFIRKIIE--------------RKLAEDEMGALPSIQSND-----KNLFLNLVT 276
               ...|...::..|.|:|              ..|.:|    |..|..||     :...|:.:.
  Fly   271 KVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDD----LDDIDENDVGAKRRLALLDAMV 331

  Fly   277 DLMRRG--VFTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDF 339
            ::.:..  .:..|::.||.|.|:|...:||:....:.|.::.:..:.|.:.|.|.|.||.:....
  Fly   332 EMAKNPDIEWNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLR 396

  Fly   340 DVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNG-IVVPKGVQIAIDIYHMHRSKK 403
            |.::|||.:|.||:.::.|::|:.||||:::|:...||||::| ..||||..:.:..|.:||...
  Fly   397 DCTFADTMEMKYLERVILETLRLYPPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPD 461

  Fly   404 IWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFP 468
            |: |:...|:||:|||..:.::|.|::|||:.|.|:|:|.:||::..||.|:.::|||...::..
  Fly   462 IY-PNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDT 525

  Fly   469 FENLYFVEDITMKLKSVPLLELQKR 493
            ..:.....||.:||::...:.|:||
  Fly   526 EADFKLQADIILKLENGFNVSLEKR 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	130/482 (27%)
Cyp4g1	NP_525031.1	p450	58..518	CDD:278495	128/478 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960