DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	134/497 - (26%)
Similarity:	223/497 - (44%)	Gaps:	59/497 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TWTL-------WCGLLFLLWIY-----------FLWSRRRFYLLTLKIPGPLGYPILGMAHWLMR 49
            ||.|       |.....|.|.|           |..|.:|.:.|     |.||        .:..
  Rat    18 TWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQSPKRNWFL-----GHLG--------TIQS 69

  Fly    50 RED---ILNAFG-CFLDKHGPTIFSWLGP-IPFMIVSDPQVVQDIFTSPHCV--NKGIIYKAVDD 107
            .|:   ::...| .|.|.|    ..|||| ||.:.:.||..|..:..:|..|  ......:.:..
  Rat    70 NEEGMRLVTEMGQTFRDIH----LCWLGPVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRFLKP 130

  Fly   108 GAGVGLFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK--DLIPLL 170
            ..|.|||.....:||.||:||.|||...:|..::.|||:...::..:.:.|..:|..  ::...:
  Rat   131 WLGDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLCLEGSARLEMFENI 195

  Fly   171 QSFTLGIATQTTMGSDVKDEESFRS--NSLLGRYQCILETMTDMCFSPWLNSRFCRQLAGKESHY 233
            ...||....:...|.|...:||...  :::|.....|::....:..  :|:..:.|...|:  .:
  Rat   196 SLMTLDSLQKCLFGFDSNCQESPSEYISAILELSSLIIKRSQQLFL--YLDFLYYRTADGR--RF 256

  Fly   234 YQAKTEIRQFIRKII-ERKLAEDEMGALPSIQS--NDKNLFLNLVTDLMRRGVFTLKNVED---- 291
            .:|...:..|...:| ||:......|....::|  ..|:..|:.:..|:.......|.:.|
  Rat   257 RKACDLVHNFTDAVIRERRRLLSSQGTDEFLESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIR 321

  Fly   292 -ESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLI 355
             |::..:||..:|||:|:.:.|..||..||||||..:|:..:..:....::.:.|..|:.:|.:.
  Rat   322 AEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMC 386

  Fly   356 LNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPH 420
            :.||:|:.||...:.|:.:||:.|.:|.|:|||....|.|:.:|.:..:| ||.|.|:|..|...
  Rat   387 IKESLRLHPPAIDLLRRCTQDIVLPDGRVIPKGNICVISIFGIHHNPSVW-PDPEVFDPFRFDSE 450

  Fly   421 NIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYR 462
            |.|.:.|.::|||:.|.|||||..:|:...||.:|..|..:|
  Rat   451 NRQKRSPLSFIPFSAGPRNCIGQTFAMNEMKVVVALTLLRFR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	123/449 (27%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	126/463 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820