DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a4 and CYP4V2

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_997235.3	Gene:	CYP4V2 / 285440	HGNCID:	23198	Length:	525	Species:	Homo sapiens

Alignment Length:	531	Identity:	143/531 - (26%)
Similarity:	256/531 - (48%)	Gaps:	57/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LWCGLLF---LLW-------------IYFLWSRRRFYLLTLKIPGPL-----GYPILGMAHWLMR 49
            ||.||::   |||             :..|..|...|....:...|:     .||::|  |.|:.
Human     4 LWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVG--HALLM 66

  Fly    50 REDILNAFGCFLD-----KHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGA 109
            :.|....|...::     :|.|.:..|:||:|.:.:.:.:.|:.|.||...::|..:||.::...
Human    67 KPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWL 131

  Fly   110 GVGLFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFT 174
            |:||.:....:|...||:|.|.|...:|..||.|.|.:..:|:.:||...:....:....:....
Human   132 GLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCA 196

  Fly   175 LGIATQTTMGSDVKDEESFRSNSLLGRYQCILETMTDMCF----SPWLNSRFCRQLAGKESHYYQ 235
            |.|..:|.||.::..:.:..|..:...|:     |::|.|    .|||..... .|..||...::
Human   197 LDIICETAMGKNIGAQSNDDSEYVRAVYR-----MSEMIFRRIKMPWLWLDLW-YLMFKEGWEHK 255

  Fly   236 AKTEI-RQFIRKIIERKLAE---------DEMGALPSIQSNDKNLFLNL---VTDLMRRGVFTLK 287
            ...:| ..|...:|..:..|         |..|:.||  .|.:..||:|   ||| ......:.:
Human   256 KSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPS--KNKRRAFLDLLLSVTD-DEGNRLSHE 317

  Fly   288 NVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYL 352
            ::.:|.:..:|...:|||.|:.::|.||...||.|::...|:..:| ...|...:..|.:::.||
Human   318 DIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVF-GKSDRPATVEDLKKLRYL 381

  Fly   353 DLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHF 417
            :.::.|::|:.|.||:.:|..|:|.::: |..|.||.:..|..|.:||..:.: |:.|.|.|:.|
Human   382 ECVIKETLRLFPSVPLFARSVSEDCEVA-GYRVLKGTEAVIIPYALHRDPRYF-PNPEEFQPERF 444

  Fly   418 LPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDITMKL 482
            .|.|.|.:|||||:||:.|.|||||.::|::..|..|:.:||::..:::...|.|.....:.::.
Human   445 FPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRP 509

  Fly   483 KSVPLLELQKR 493
            .:...::|::|
Human   510 SNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	129/458 (28%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	130/475 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810