Protein Alignment Cyp313a4 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 137/523 - (26%)
• Similarity: 233/523 - (44%)
• Gaps: 86/523 - (16%)

  Fly    10 LLFLLWIYFLWSRRRFYLLTL-KIPGPLGYPILGMAHW-------------LMRREDILNAF--G 58
            ||.|:....|:..|::.|..| :.|.|       .:||             |.|.::.:..|  .
Human    28 LLLLIKAAQLYLHRQWLLKALQQFPCP-------PSHWLFGHIQEFQHDQELQRIQERVKTFPSA 85

  Fly    59 CFLDKHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSI 123
            |       ..:.|.|.:...:. ||..::.|.......:.| .||.:....|.||..|....|..
Human    86 C-------PYWIWGGKVRVQLY-DPDYMKVILGRSDPKSHG-SYKFLAPRIGYGLLLLNGQTWFQ 141

  Fly   124 HRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVK 188
            ||::|.|||.:.:|..::.:......::||:.|.|.  |:...:.:.|..:| :...|.|.|...
Human   142 HRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELL--GQDSPLEVFQHVSL-MTLDTIMKSAFS 203

  Fly   189 DEESFR--SNSLLGRYQCILETMTDMCFSPWLNSR-FC--------------RQLAGKESHYYQA 236
            .:.|.:  .||     |..::.::|      |||. ||              ...||:.:|  :|
Human   204 HQGSIQVDRNS-----QSYIQAISD------LNSLVFCCMRNAFHENDTIYSLTSAGRWTH--RA 255

  Fly   237 KTEIRQFIRKIIE-RKLAEDEMGALPSIQSNDKNLFLN--LVTDLMRRGVFTLKNVEDESNIIVF 298
            .....|...::|: ||....:.|.|..|:......||:  |:..:....:.:.|::..|.:..:|
Human   256 CQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMF 320

  Fly   299 GAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGD-FDVSYADTQQMVYLDLILNESMRV 362
            ...:|||:.:.:.|..||..|::|||..|||..:.   || ..:::....||.|..:.:.|::|:
Human   321 EGHDTTASGISWILYALATHPKHQERCREEIHGLL---GDGASITWNHLDQMPYTTMCIKEALRL 382

  Fly   363 IPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHP 427
            .||||.:.|:.|..:...:|..:|||:.:.:.||.:|.:.|:| |:.|.|:|..|.|.:.|  |.
Human   383 YPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVW-PNLEVFDPSRFAPGSAQ--HS 444

  Fly   428 YAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFK-----TSFPFENLYFV----EDITMKLK 483
            :|::||:.|.|||||.::|:...||  |:.|...||:     |..|......|    ..|.::|:
Human   445 HAFLPFSGGSRNCIGKQFAMNQLKV--ARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLR 507

  Fly   484 SVP 486
            .:|
Human   508 RLP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	122/452 (27%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	124/465 (27%)