Protein Alignment Cyp313a4 and CYP4A22

DIOPT Version :9

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 137/523 - (26%)
• Similarity: 233/523 - (44%)
• Gaps: 86/523 - (16%)

  Fly    10 LLFLLWIYFLWSRRRFYLLTL-KIPGPLGYPILGMAHW-------------LMRREDILNAF--G 58
            ||.|:....|:..|::.|..| :.|.|       .:||             |.|.::.:..|  .
Human    28 LLLLIKAAQLYLHRQWLLKALQQFPCP-------PSHWLFGHIQEFQHDQELQRIQERVKTFPSA 85

  Fly    59 CFLDKHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSI 123
            |       ..:.|.|.:...:. ||..::.|.......:.| .||.:....|.||..|....|..
Human    86 C-------PYWIWGGKVRVQLY-DPDYMKVILGRSDPKSHG-SYKFLAPRIGYGLLLLNGQTWFQ 141

  Fly   124 HRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVK 188
            ||::|.|||.:.:|..::.:......::||:.|.|.  |:...:.:.|..:| :...|.|.|...
Human   142 HRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELL--GQDSPLEVFQHVSL-MTLDTIMKSAFS 203

  Fly   189 DEESFR--SNSLLGRYQCILETMTDMCFSPWLNSR-FC--------------RQLAGKESHYYQA 236
            .:.|.:  .||     |..::.::|      |||. ||              ...||:.:|  :|
Human   204 HQGSIQVDRNS-----QSYIQAISD------LNSLVFCCMRNAFHENDTIYSLTSAGRWTH--RA 255

  Fly   237 KTEIRQFIRKIIE-RKLAEDEMGALPSIQSNDKNLFLN--LVTDLMRRGVFTLKNVEDESNIIVF 298
            .....|...::|: ||....:.|.|..|:......||:  |:..:....:.:.|::..|.:..:|
Human   256 CQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMF 320

  Fly   299 GAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGD-FDVSYADTQQMVYLDLILNESMRV 362
            ...:|||:.:.:.|..||..|::|||..|||..:.   || ..:::....||.|..:.:.|::|:
Human   321 EGHDTTASGISWILYALATHPKHQERCREEIHGLL---GDGASITWNHLDQMPYTTMCIKEALRL 382

  Fly   363 IPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHP 427
            .||||.:.|:.|..:...:|..:|||:.:.:.||.:|.:.|:| |:.|.|:|..|.|.:.|  |.
Human   383 YPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVW-PNLEVFDPSRFAPGSAQ--HS 444

  Fly   428 YAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFK-----TSFPFENLYFV----EDITMKLK 483
            :|::||:.|.|||||.::|:...||  |:.|...||:     |..|......|    ..|.::|:
Human   445 HAFLPFSGGSRNCIGKQFAMNQLKV--ARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLR 507

  Fly   484 SVP 486
            .:|
Human   508 RLP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	124/472 (26%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	128/492 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820