DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4a12a

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_803125.2	Gene:	Cyp4a12a / 277753	MGIID:	88612	Length:	508	Species:	Mus musculus

Alignment Length:	519	Identity:	134/519 - (25%)
Similarity:	232/519 - (44%)	Gaps:	72/519 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLFLLWIYF----LWSRRRFYL-LTLKIPGPLGYPILGMAHWLMRR--------EDILNAFGCFL 61
            :|.||.:.|    |:..|::.| .|.:.|.|       .:|||...        :|||...
Mouse    24 VLSLLLLLFKTAQLYLHRQWLLSSTQQFPSP-------PSHWLFGHKILKDQDLQDILTRI---- 77

  Fly    62 DKHGPTIF-SWL-GPIPFMIVSDPQVVQDIF--TSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWS 122
             |:.|:.. .|| |....:.|.||..::.|.  :.|.....   |:.:....|.||..|....|.
Mouse    78 -KNFPSACPQWLWGSKVRIQVYDPDYMKLILGRSDPKANGS---YRFLAPWIGRGLLMLDGQTWF 138

  Fly   123 IHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDV 187
            .||::|.|||.:.:|..:..|......::||:.|  |..|:...:.:.:..|| :...|.|....
Mouse   139 QHRRMLTPAFHYDILKPYTEIMADSVRVMLDKWE--QIVGQDSTLEIFRHITL-MTLDTIMKCAF 200

  Fly   188 KDEESFRSNSLLGRYQCILETMTDMCFSPWLN------------SRFCR-QLAGKESHYYQAKTE 239
            ..|.|.:.:.....|...:|.:.|:.||...|            |..|: ..|.|.:|.:..:.
Mouse   201 SHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRNIFHQNDIIYRVSSNGCKANSACKLAHDHTDQV- 264

  Fly   240 IRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLN-LVTDLMRRG-VFTLKNVEDESNIIVFGAFE 302
                   |..|::...:...|..::...:..||: |:...|..| ..:.|::..|.:..:|...:
Mouse   265 -------IKSRRIQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHD 322

  Fly   303 TTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGD-FDVSYADTQQMVYLDLILNESMRVIPPV 366
            |||:.:.:....||..||:|:|..:||:::.   || ..:::.|..:|.|..:.:.|::|:.|||
Mouse   323 TTASGISWIFYALATNPEHQQRCRKEIQSLL---GDGTSITWNDLDKMPYTTMCIKEALRIYPPV 384

  Fly   367 PVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYI 431
            |.|||:.|..:...:|..:|||:.:.:..|.:|.:..:| |:.|.|:|..|.|.:  .:|.::::
Mouse   385 PSVSRELSSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVW-PNPEVFDPSRFAPGS--SRHSHSFL 446

  Fly   432 PFTKGIRNCIGWRYALISAKVTLAKLLRNYRF---KTSFPFENLYFVEDITMKLKSVPLLELQK 492
            ||:.|.|||||.::|:...||.:|..|..:..   .|..|..    :..|.:|.|:...|.|:|
Mouse   447 PFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIP----IPRIVLKSKNGIHLHLKK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	118/462 (26%)
Cyp4a12a	NP_803125.2	p450	52..502	CDD:278495	123/485 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900