DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a4 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	146/535 - (27%)
Similarity:	254/535 - (47%)	Gaps:	58/535 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTWTLWCGL---LFLLW-----------------IYFLWSRRRFYLLTLKIPG-PLGYPILGMAH 45
            :.| ||.||   ..|||                 :..|.|..|.:.....||. ...||::|  |
  Rat     1 MLW-LWLGLSGQKLLLWGAASAVSVAGATVLLNILQMLVSYARKWQQMRPIPSVARAYPLVG--H 62

  Fly    46 WLMRREDILNAFGCFLD-----KHGPTIFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAV 105
            .|..:.:....|...:.     :|.|.|..|:||:|.:.:...:.|:.|.||...::|..:||.:
  Rat    63 ALFMKPNNTEFFQQIIQYTEEFRHLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFMYKFL 127

  Fly   106 DDGAGVGLFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEP-LQDDGEKDLIPL 169
            ....|:||.:....:|...||:|.|:|...:|..||.:.|.:..:|:::||. :..:......|:
  Rat   128 QPWLGLGLLTSTGSKWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVNQEAFNCFFPI 192

  Fly   170 LQSFTLGIATQTTMGSDVKDEESFRSNSLLGRYQCILETMTDMCF----SPWLNSRFCRQLAGKE 230
            ... .|.|..:|.||.::..:.:..|..:...|:     |:||.:    .||........:..:.
  Rat   193 TLC-ALDIICETAMGKNIGAQSNGDSEYVRTVYR-----MSDMIYRRMKMPWFWFDLWYLMFKEG 251

  Fly   231 SHYYQAKTEIRQFIRKII-----ERKLAEDEMGA----LPSIQSNDKNLFLNL---VTDLMRRGV 283
            ..:.:....:..|...:|     .||..:|.:||    |||  ...:..||:|   ||| .....
  Rat   252 RDHKKGLKSLHTFTNNVIAERVNARKAEQDCIGAGRGPLPS--KTKRKAFLDLLLSVTD-EEGNK 313

  Fly   284 FTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQ 348
            .:.:::.:|.:..:|...:|||.|:.::|.||...||.|.:..:|:..:| ......|:..|.::
  Rat   314 LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVF-GRSHRPVTLEDLKK 377

  Fly   349 MVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFN 413
            :.|||.::.|::||.|.||:.:|..|:|.::: |..:.||.:..|..|.:||..:.: ||.|.|.
  Rat   378 LKYLDCVIKETLRVFPSVPLFARSLSEDCEVA-GYKISKGTEAVIIPYALHRDPRYF-PDPEEFQ 440

  Fly   414 PDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRFKTSFPFENLYFVEDI 478
            |:.|.|.|.|.:|||||:||:.|.|||||.::|::..|..||.:||.:..:::...|.|....|:
  Rat   441 PERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWIESNQKREELGLAGDL 505

  Fly   479 TMKLKSVPLLELQKR 493
            .::..:...::|::|
  Rat   506 ILRPNNGIWIKLKRR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	129/454 (28%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	125/450 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810