DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a4 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	135/482 - (28%)
Similarity:	224/482 - (46%)	Gaps:	51/482 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WCGLLFLLWIYFLWS---RRRFYLLTLKIPGPLGYPILGMAHW----LMRRED-----ILNAFGC 59
            |.....|.|||..:.   |.|.:   .:.|.|..:       |    ||:..:     |.:....
  Rat    30 WILARILAWIYTFYDNCCRLRCF---PQPPKPSWF-------WGHLTLMKNNEEGMQFIAHLGRN 84

  Fly    60 FLDKHGPTIFSWLGPI-PFMIVSDPQVVQDIFTSPHCV--NKGIIYKAVDDGAGVGLFSLKDPRW 121
            |.|.|    .||:||: |.:.:..|.|:..:..:...|  .:..:|..:....|.||......:|
  Rat    85 FRDIH----LSWVGPVYPILRLVHPNVIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGEKW 145

  Fly   122 SIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEK--DLIPLLQSFTLGIATQTTMG 184
            :.||:||.|||...:|.|::.|||:....:..:.:.|...|..  |:...:...||....:....
  Rat   146 NHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSARLDMFEHISLMTLDSLQKCIFS 210

  Fly   185 SDVKDEESFRSNSLLGRYQCILETMTDMCF----SPWLNSRFCRQLAGKESHYYQAKTEIRQFIR 245
            .|...:|   |||   .|...:..::.:..    .|:|...|...|......:.:|...:..|..
  Rat   211 FDSNCQE---SNS---EYIAAILELSSLIVKRQRQPFLYLDFLYYLTADGRRFRKACDVVHNFTD 269

  Fly   246 KII-ERKLAEDEMGALPSIQSNDKNLFLNLVTDLM------RRGVFTLKNVEDESNIIVFGAFET 303
            .:| ||:...:..|....:::..|...|:.:..|:      .:|:..: ::..|::..:||..:|
  Rat   270 AVIRERRSTLNTQGVDEFLKARAKTKTLDFIDVLLLAKDEHGKGLSDV-DIRAEADTFMFGGHDT 333

  Fly   304 TANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPV 368
            ||:|:.:.|..||..||||||..:|::.:..:....::.:.|..|:.:|.:.:.||:|:.|||.:
  Rat   334 TASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVLL 398

  Fly   369 VSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPF 433
            :||..|||:.|.:|.|:|||....|.|:.:|.:..:| ||.|.:||..|.|.|.|.:.|.|:|||
  Rat   399 ISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVW-PDPEVYNPFRFDPENPQKRSPLAFIPF 462

  Fly   434 TKGIRNCIGWRYALISAKVTLA-KLLR 459
            :.|.|||||..:|:...||.|| .|||
  Rat   463 SAGPRNCIGQTFAMSEIKVALALTLLR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	128/453 (28%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	128/456 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810