Protein Alignment Cyp313a4 and Cyp4a8

DIOPT Version :10

• Sequence 1: NP_650224.3
• Gene: Cyp313a4 / 41563
• FlyBaseID: FBgn0038076
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_113793.2
• Gene: Cyp4a8 / 266674
• RGDID: 628846
• Length: 508
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 132/543 - (24%)
• Similarity: 229/543 - (42%)
• Gaps: 94/543 - (17%)

  Fly     2 LTWTLWCGLLF--------LLWIYFLWSRRRFYL-------LTLKIPGPLGYPILGMAHWLMRR- 50
            |::|::.|.:.        |..:..|:...:|||       .|.:.|.|       .:||....
  Rat     6 LSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSP-------PSHWFFGHK 63

  Fly    51 -------EDILNAFGCFLDKHGPTIF-SWL-GPIPFMIVSDPQVVQDIF-----TSPHCVNKGII 101
                   :|||...     |:.|:.. .|| |....:.|.||..::.|.     .|.|.
  Rat    64 IPKDQEFQDILTRV-----KNFPSACPQWLWGSNVRIQVYDPDYMKLILGRSDPKSHHS------ 117

  Fly   102 YKAVDDGAGVGLFSLKDPRWSIHRKLLNPAFGHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDL 166
            |:.:....|.||..|....|..||::|.|||.:..|..::.|......::||:.|  |..|:...
  Rat   118 YRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWE--QIVGQDST 180

  Fly   167 IPLLQSFTLGIATQTTMGSDVKDEESFRSNSLLGRYQCILETM--------------TDMCFSPW 217
            :.:.|..|| :...|.|......|.|.:.:.....|...:|.:              .|:.:|..
  Rat   181 LEIFQHITL-MTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLS 244

  Fly   218 LNSRFCRQLAGKESHYYQAKTEIRQFIRKIIERKLAEDEMGALPSIQSNDKNLFLNLVTDLMRR- 281
            .|.|..|      |.:..|.....|.|:   .||....:...|..::...:..||:::  |..|
  Rat   245 SNGRKAR------SAWQLAHEHTDQVIK---SRKAQLQDEEELQKVKQKRRLDFLDIL--LFARI 298

  Fly   282 ---GVFTLKNVEDESNIIVFGAFETTANAVYYTLMLLAMFPEYQERAFEEIKTIFPNTGD-FDVS 342
               ...:.|::..|.:..:|...:|||:.:.:....||..||:|:...:||:::.   || ..::
  Rat   299 ENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLL---GDGASIT 360

  Fly   343 YADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDLKLSNGIVVPKGVQIAIDIYHMHRSKKIWGP 407
            :.|..:|.|..:.:.|::|:.|||..|||..|..:...:|..:|||:.:.:..|.:|.:..:| |
  Rat   361 WDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVW-P 424

  Fly   408 DAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIGWRYALISAKVTLAKLLRNYRF---KTSFPF 469
            :.|.|:|..|.|.:  .:|.::::||:.|.|||||.::|:...||.:|..|..:..   .|..|.
  Rat   425 NPEVFDPYRFAPES--SRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPI 487

  Fly   470 ENLYFVEDITMKLKSVPLLELQK 492
            .    :..:.:|.|:...|.|:|
  Rat   488 P----IPRLVLKSKNGIYLRLKK 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a4	NP_650224.3	CYP313-like	65..489	CDD:410680	112/452 (25%)
Cyp4a8	NP_113793.2	CYP4B-like	70..503	CDD:410771	116/467 (25%)